Institute of Science and Technology to study Diseases Associated with Papillomavirus

• Grant number: 08/57889-1
• Support Opportunities: Research Projects - Thematic Grants
• Start date: March 01, 2009
• End date: June 30, 2017
• Field of knowledge: Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
• Agreement: CNPq - INCTs
• Principal Investigator: Luisa Lina Villa
• Grantee: Luisa Lina Villa
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The human papilomavirus (HPV) is responsible for one of the most common sexually transmitted disease in the world, infecting the anogenital and oropharyngeal mucosa and the skin causing malignant and benign neoplastic lesions. It is estimated that at least 50% of sexually active people are infected with at least one type of HPV. HPVs cause about 250,000 deaths per year from cervical cancer, most often in developing countries. It is responsible for a significant burden of disease and as such control of HPV infections and related tumors should be part of the public health agenda of any country. In Brazil it is estimated that 700 thousand new cases of HPV infection and 20 thousand new cases of cervical cancer will occur each year. Moreover, the cost for cervical cancer screening is increasingly high and not so efficient in controlling death from this frequent cancer. These facts justify the creation of an Institute dedicated to the study of such infections and diseases. The Brazilian Minister of Science and Technology launched a program of National Institutes of Science and Technology (NIST) with a thematic organization on strategical topics with potential scientific and technological impact and social relevance. One of the goals of the NIST is to provide technical training capacity, train professionals of higher level through specialization courses at post-graduation level; and the dissemination and transfer of solutions to relevant issues for the entire society. Relationships between the NIST and private companies should be fostered in order to accelerate the generation of innovations and patents. With these goals in mind we have outlined an HPV-themed project covering several aspects of the infections and tumors that affect a substantial proportion of individuals, with particular attention to dissemination of the information to the public. To reach such objectives we devised medium-and long-term research projects to be conducted at the HPV NIST located at Santa Casa de São Paulo. Human resources training at different levels are part of the HPV NIST activities including undergraduate and graduate students training both in short training courses or full graduation programs to be created at Santa Casa de São Paulo to provide theoretical-practical training about aspects of the HPV Biology and Epidemiology, all the way to treatment of HPV-related tumors and prevention of HPV infections. Knowledge transfer to society will explore the Santa Casa de São Paulo long experience on community projects including EducaSãoMiguel (social project aimed at training health agents and disease awareness to the general population); Expeditions (social project that provides comprehensive medical care associated with population guidance topics specific to poor communities); Teenage pregnancy (which gives global assistance to pregnant adolescents of the central region of the city of São Paulo) and the EDUCASUS, a network of different Santa-Casa hospitals (that aims distance training of health professionals of 375 hospitals from the State of São Paulo). A centralized computer-assisted system is in place for submitting projects to be supported by this NIST and all steps of the process, from funding to publication is accompanied through an extranet dedicated to the program acessible at the site www.incthpv.org.br. Clinical specimens and data is provided to investigators with the collaboration with the clinical, surgical and pathology services of Santa Casa and other collaborating institutions. Such partnership will be able to provide competent basic to applied research aiming to solve relevant health problems with innovativ ideas and solutions. As institutional counterpart for a project of this magnitude the Irmandade da Santa Casa de Misericordia de São Paulo and the School of Medicine of Santa Casa de São Paulo provided laboratories, offices and classrooms; clinical research facilities; personnel such as laboratory technicians, researchers, nurses, social workers and administrative personnel, as well as building maintenance and IT facilities. The HPV NIST established a collaborative network formed by many of the top institutions in the country including the School of Medicine of Santa Casa de São Paulo and of the University of São Paulo, several services at the main hospitals of Santa Casa de Misericórdia de São Paulo (ICMSCSP), the Ludwig Institute for Cancer Research, Emilio Ribas Hospital, Instituto Adolfo Lutz, Reference Center for STD/AIDS, Tide Setubal Foundation, School of Medicine at UNIFESP, among other with the participation of the specialties Gynecology, dermatology, otorhinolaryngology, head and neck surgery, urology and proctology and will provide a continuous flow of patients and clinical information. Different projects are conducted at the central laboratories of molecular biology and virology of the HPV NIST,including a) evaluation of HPV testing as an alternative cervical cancer screening tool; b) search of tumor markers and targets for novel diagnostic and therapeutic tools to control HPV-related diseases; genomics and transcriptomics of HPV-related tumors of the uterine cervix and head and neck anatomycal location. Finally, we aim to contribute highly qualified professionals in the field, as well as to transfer technology and information to laboratories, clinics, and to disseminate general information and education at all levels, including the lay public. (AU)

Scientific publications

(52)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NETO PIMENTEL, D. R.; MONTOSA NUNES, E.; TERMINI, L.; ALMEIDA LIMA NUNES, R.; MENDOZA LOPEZ, R. V.; FERREIRA, S.; BOCCARDO, E.; MANN PRADO, J. C.; ENOKIHARA, M. M. S. S.; SICHERO, L.; et al. Detection of human papillomaviruses and human polyomaviruses in immunosuppressed and immunocompetent individuals with actinic cheilitis: a case series. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, v. 33, n. 12, JULY 2019. (08/57889-1)

LEVI, JOSE EDUARDO; MARTINS, TONI RICARDO; LONGATTO-FILHO, ADHEMAR; COHEN, DIANE DEDE; CURY, USE; FUZA, LUIZ MARIO; VILLA, LUISA L.; ELUF-NETO, JOSE. High-Risk HPV Testing in Primary Screening for Cervical Cancer in the Public Health System, Sao Paulo, Brazil. Cancer Prevention Research, v. 12, n. 8, p. 539-546, AUG 2019. (08/57889-1)

HERBSTER, SUELLEN; PALADINO, ANDRESSA; DE FREITAS, SUMARA; BOCCARDO, ENRIQUE. Alterations in the expression and activity of extracellular matrix components in HPV-associated infections and diseases. Clinics, v. 73, n. 1, 2018. (08/57889-1, 13/27006-9)

RABACHINI, TATIANA; BOCCARDO, ENRIQUE; ANDRADE, RUBIANA; PEREZ, KATIA REGINA; NONOGAKI, SUELY; CUCCOVIA, IOLANDA MIDEA; VILLA, LUISA LINA. HPV-16 E7 expression up-regulates phospholipase D activity and promotes rapamycin resistance in a pRB-dependent manner. BMC CANCER, v. 18, APR 27 2018. (10/20002-0, 08/57889-1, 08/03232-1)

FERNANDEZ ALVAREZ, KARLA LUCIA; BELDI, MARIANA; SARMANHO, FABIANE; MARQUES ROSSETTI, RENATA ARIZA; FARINA SILVEIRA, CAIO RAONY; MOTA, GIANA RABELLO; ANDREOLI, MARIA ANTONIETA; DE CARVALHO CARUSO, ELIANA DIAS; KAMILLOS, MARCIA FERREIRA; SOUZA, ANA MARTA; et al. Local and systemic immunomodulatory mechanisms triggered by Human Papillomavirus transformed cells: a potential role for G-CSF and neutrophils. SCIENTIFIC REPORTS, v. 7, AUG 21 2017. (08/57889-1, 14/19326-6)

ELLEN DIAS DE OLIVEIRA CHIANG; MISHA L. BAKER; DANIELLA FIGUEROA-DOWNING; MARIA LUIZA BAGGIO; LUISA VILLA; JOSE ELUF NETO; CRAIG HADLEY; ROBERT A. BEDNARCZYK; DABNEY P EVANS. "Those who love, vaccinate": parental perceptions of HPV vaccination. Revista brasileira de crescimento e desenvolvimento humano, v. 25, n. 3, p. -, 2015. (08/57889-1)

FLORES-DIAZ, EMA; SEREDAY, KAREN A.; FERREIRA, SILVANEIDE; SIRAK, BRADLEY; SOBRINHO, JOAO SIMAO; BAGGIO, MARIA LUIZA; GALAN, LENICE; SILVA, ROBERTO C.; LAZCANO-PONCE, EDUARDO; GIULIANO, ANNA R.; et al. HPV-11 variability, persistence and progression to genital warts in men: the HIM study. JOURNAL OF GENERAL VIROLOGY, v. 98, n. 9, p. 2339-2342, SEP 2017. (08/57889-1)

DA COSTA, ALLINI MAFRA; GUERREIRO FREGNANI, JOSE HUMBERTO TAVARES; AGUIAR PASTREZ, PAULA ROBERTA; MARIANO, VANIA SAMMARTINO; SILVA, ESTELA MARIA; NETO, CRISTOVAM SCAPULATEMPO; GUIMARAES, DENISE PEIXOTO; VILLA, LUISA LINA; SICHERO, LAURA; SYRJANEN, KARI JUHANI; et al. HPV infection and p53 and p16 expression in esophageal cancer: are they prognostic factors?. INFECTIOUS AGENTS AND CANCER, v. 12, OCT 13 2017. (08/57889-1)

MARTINS, TONI RICARDO; DE OLIVEIRA, CRISTINA MENDES; ROSA, LUCIANA REIS; CENTRONE, CRISTIANE DE CAMPOS; REGINA RODRIGUES, CELIA LUIZA; VILLA, LUISA LINA; LEVI, JOSE EDUARDO. HPV genotype distribution in Brazilian women with and without cervical lesions: correlation to cytological data. VIROLOGY JOURNAL, v. 13, AUG 12 2016. (08/57889-1)

NUNES, EMILY MONTOSA; SUDENGA, STACI L.; GHEIT, TARIK; TOMMASINO, MASSIMO; BAGGIO, MARIA LUIZA; FERREIRA, SILVANEIDE; GALAN, LENICE; SILVA, ROBERTO C.; CAMPBELL, CHRISTINE M. PIERCE; LAZCANO-PONCE, EDUARDO; et al. Diversity of beta-papillomavirus at anogenital and oral anatomic sites of men: The HIM Study. VIROLOGY, v. 495, p. 33-41, AUG 2016. (13/01440-4, 13/20470-1, 15/12557-5, 08/57889-1)

STONE, SIMONE CARDOZO; MARQUES ROSSETTI, RENATA ARIZA; FERNANDEZ ALVAREZ, KARLA LUCIA; CARVALHO, JESUS PAULA; RAMOS MARGARIDO, PAULO FRANCISCO; BARACAT, EDMUND CHADA; TACLA, MARICY; BOCCARDO, ENRIQUE; YOKOCHI, KAORI; LORENZI, NOELY PAULA; et al. Lactate secreted by cervical cancer cells modulates macrophage phenotype. Journal of Leukocyte Biology, v. 105, n. 5, p. 1041-1054, MAY 2019. (08/57889-1, 14/19326-6)

HOCHMANN, JIMENA; SOBRINHO, JOAO S.; VILLA, LUISA L.; SICHERO, LAURA. The Asian-American variant of human papillomavirus type 16 exhibits higher activation of MAPK and PI3K/AKT signaling pathways, transformation, migration and invasion of primary human keratinocytes. VIROLOGY, v. 492, p. 145-154, MAY 2016. (13/01538-4, 12/16283-9, 08/57889-1)

AGUIAR PASTREZ, PAULA ROBERTA; MARIANO, VANIA SAMMARTINO; DA COSTA, ALLINI MAFRA; SILVA, ESTELA MARIA; SCAPULATEMPO-NETO, CRISTOVAM; GUIMARAES, DENISE PEIXOTO; FAVA, GILBERTO; ZEMI NETO, SAID ABDALA; NUNES, EMILY MONTOSA; SICHERO, LAURA; et al. The Relation of HPV Infection and Expression of p53 and p16 Proteins in Esophageal Squamous Cells Carcinoma. JOURNAL OF CANCER, v. 8, n. 6, p. 1062-1070, 2017. (13/15968-0, 08/57889-1)

CABECA, TATIANE KAREN; ABREU, ALICE DE MELLO; ANDRETTE, RAFAEL; LINO, VANESCA DE SOUZA; MORALE, MIRIAN GALLIOTE; AGUAYO, FRANCISCO; TERMINI, LARA; VILLA, LUISA LINA; LEPIQUE, ANA PAULA; BOCCARDO, ENRIQUE. HPV-Mediated Resistance to TNF and TRAIL Is Characterized by Global Alterations in Apoptosis Regulatory Factors, Dysregulation of Death Receptors, and Induction of ROS/RNS. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 1, JAN 1 2019. (11/14416-9, 08/03232-1, 10/20002-0, 08/57889-1)

FARINA SILVEIRA, CAIO RAONY; CIPELLI, MARCELLA; MANZINE, CAROLINA; RABELO-SANTOS, SILVIA HELENA; ZEFERINO, LUIZ CARLOS; RODRIGUEZ, GRETEL RODRIGUEZ; DE ASSIS, JOSIANE BETIM; HEBSTER, SUELLEN; BERNADINELLI, ISABEL; LAGINHA, FABIO; et al. Swainsonine, an alpha-mannosidase inhibitor, may worsen cervical cancer progression through the increase in myeloid derived suppressor cells population. PLoS One, v. 14, n. 3, MAR 6 2019. (14/19326-6, 08/57889-1)

DA COSTA, ALLINI MAFRA; TAVARES GUERREIRO FREGNANI, JOSE HUMBERTO; AGUIAR PASTREZ, PAULA ROBERTA; MARIANO, VANIA SAMMARTINO; SCAPULATEMPO NETO, CRISTOVAM; GUIMARAES, DENISE PEIXOTO; GIORDINA DE OLIVEIRA, KELLY MENEZIO; ZEMI NETO, SAID ABDALA; NUNES, EMILY MONTOSA; FERREIRA, SILVANEIDE; et al. Prevalence of high risk HPV DNA in esophagus is high in Brazil but not related to esophageal squamous cell carcinoma. HISTOLOGY AND HISTOPATHOLOGY, v. 33, n. 4, p. 357-363, APR 2018. (08/57889-1)

SUELLEN HERBSTER; ANDRESSA PALADINO; SUMARA DE FREITAS; ENRIQUE BOCCARDO. Alterations in the expression and activity of extracellular matrix components in HPV-associated infections and diseases. Clinics, v. 73, 2018-09-06. (13/27006-9, 08/57889-1)

MARTINS, TONI RICARDO; LONGATTO-FILHO, ADHEMAR; COHEN, DIANE; KODAIRA VISCONDI, JULIANA YUKARI; FUZA, LUIZ MARIO; CURY, LISE; VILLA, LUISA LINA; LEVI, JOSE EDUARDO; ELUF-NETO, JOSE. Influence of Prior Knowledge of Human Papillomavirus Status on the Performance of Cytology Screening. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, v. 149, n. 4, p. 316-323, APR 2018. (08/57889-1)

MORALE, MIRIAN GALLIOTE; TAMURA, RODRIGO ESAKI; CINTRA, RICARDO; ARAUJO, NATALIA MENESES; VILLA, LUISA LINA. TLR4 and SARM1 modulate survival and chemoresistance in an HPV-positive cervical cancer cell line. SCIENTIFIC REPORTS, v. 12, n. 1, p. 12-pg., 2022-04-25. (16/25139-0, 19/15619-2, 08/57889-1, 08/03232-1)

TALARICO, MARIA CECILIA RAMIRO; NUNES, RAFAELLA ALMEIDA LIMA; SILVA, GABRIELA AVILA FERNANDES; COSTA, LARISSA BASTOS ELOY DA; CARDOSO, MARCELLA REGINA; ESTEVES, SERGIO CARLOS BARROS; ZANATTA SARIAN, LUIS OTAVIO; ZEFERINO, LUIZ CARLOS; TERMINI, LARA. High Expression of SOD2 Protein Is a Strong Prognostic Factor for Stage IIIB Squamous Cell Cervical Carcinoma. ANTIOXIDANTS, v. 10, n. 5, MAY 2021. (12/16059-1, 10/07739-3, 15/26573-2, 08/57889-1)

BISPO, SALOE; FARIAS, TICIANA D. J.; DE ARAUJO-SOUZA, PATRICIA SAVIO; CINTRA, RICARDO; SANTOS, HELLEN GEREMIAS DOS; JORGE, NATASHA ANDRESSA NOGUEIRA; CASTRO, MAURO ANTONIO ALVES; WAJNBERG, GABRIEL; SCHERER, NICOLE DE MIRANDA; GENTA, MARIA LUIZA NOGUEIRA DIAS; et al. Dysregulation of Transcription Factor Networks Unveils Different Pathways in Human Papillomavirus 16-Positive Squamous Cell Carcinoma and Adenocarcinoma of the Uterine Cervix. FRONTIERS IN ONCOLOGY, v. 11, MAY 19 2021. (08/57889-1)

GONCALVES, MILENA GIULIA; FERREIRA, MATTHEW THOMAS; MENDOZA LOPEZ, ROSSANA VERONICA; FERREIRA, SILVANEIDE; SIRAK, BRADLEY; BAGGIO, MARIA LUIZA; LAZCANO-PONCE, EDUARDO; NYITRAY, ALAN G.; GIULIANO, ANNA R.; VILLA, LUISA L.; et al. Prevalence and persistence of HPV-16 molecular variants in the anal canal of men: The HIM study. Journal of Clinical Virology, v. 149, p. 7-pg., 2022-03-22. (08/57889-1, 17/23211-8)

MARQUES ROSSETTI, RENATA ARIZA; RODRIGUEZ, GRETEL RODRIGUEZ; DA SILVA, ILDELFONSO ALVES, JR.; CARVALHO, JESUS DE PAULA; SARTOR DE FARIA ROSA, MARIA BEATRIZ; VILLA, LUISA LINA; LEPIQUE, ANA PAULA. Cervical cancer immunomodulation through stat3 and p65 NF kappa b: Effects beyond the tumor microenvironment.. CANCER IMMUNOLOGY RESEARCH, v. 8, n. 4, p. 1-pg., 2020-04-01. (08/57889-1, 14/19326-6)

LONGATTO-FILHO, ADHEMAR; FREGNANI, JOSE HUMBERTO; DA COSTA, ALLINI MAFRA; DE ARAUJO-SOUZA, PATRICIA SAVIO; SCAPULATEMPO-NETO, CRISTOVAM; HERBSTER, SUELLEN; BOCCARDO, ENRIQUE; TERMINI, LARA. Evaluation of Elafin Immunohistochemical Expression as Marker of Cervical Cancer Severity. ACTA CYTOLOGICA, v. 65, n. 2, p. 10-pg., 2020-12-03. (08/57889-1, 18/22097-0)

LONGATTO-FILHO, ADHEMAR; FREGNANI, JOSE HUMBERTO; DA COSTA, ALLINI MAFRA; DE ARAUJO-SOUZA, PATRICIA SAVIO; SCAPULATEMPO-NETO, CRISTOVAM; HERBSTER, SUELLEN; BOCCARDO, ENRIQUE; TERMINI, LARA. Evaluation of Elafin Immunohistochemical Expression as Marker of Cervical Cancer Severity. ACTA CYTOLOGICA, DEC 2020. (08/57889-1, 18/22097-0)

LORENZI, NOELY P. C.; TERMINI, LARA; FERREIRA-FILHO, EDSON S.; NUNES, RAFAELLA A. L.; SILVA, GABRIELA A. F.; LEPIQUE, ANA P.; LONGATTO-FILHO, ADHEMAR; TACLA, MARICY; BARACAT, EDMUND C.; VILLA, LUISA L.; et al. A positive HPV test with positive p16/Ki-67 double staining in self-sampled vaginal material is an accurate tool to detect women at risk for cervical cancer. CANCER CYTOPATHOLOGY, v. 130, n. 1, AUG 2021. (15/26573-2, 16/16847-0, 08/57889-1, 15/26327-1)

BUSS, LEWIS F.; LEVI, JOSE E.; LONGATTO-FILHO, ADHEMAR; COHEN, DIANE D.; CURY, LISE; MARTINS, TONI R.; FUZA, LUIZ M.; VILLA, LUISA L.; ELUF-NETO, JOSE. Attendance for diagnostic colposcopy among high-risk human papillomavirus positive women in a Brazilian feasibility study. International Journal of Gynecology & Obstetrics, v. 152, n. 1, p. 72-77, JAN 2021. (08/57889-1)

SILVA, ESTELA MARIA; MARIANO, VANIA SAMMARTINO; AGUIAR PASTREZ, PAULA ROBERTA; PINTO, MIGUEL CORDOBA; NUNES, EMILY MONTOSA; SICHERO, LAURA; VILLA, LUISA LINA; SCAPULATEMPO-NETO, CRISTOVAM; SYRJANEN, KARI JUHANI; LONGATTO-FILHO, ADHEMAR. Human papillomavirus is not associated to non-small cell lung cancer: data from a prospective cross-sectional study. INFECTIOUS AGENTS AND CANCER, v. 14, n. 1, AUG 2 2019. (08/57889-1, 14/23414-8)

FERREIRA, SILVANEIDE; FRANCO, EDUARDO L.; VILLA, LUISA L.; BAGGIO, MARIA LUIZA; GALAN, LENICE; SOBRINHO, JOAO SIMAO; MANN PRADO, JOSE CARLOS; TERMINI, LARA; COSTA, MARIA CECILIA; MIYAMURA, ROMULO; et al. Lack of Association between Human Papillomavirus Types 6 and 11 Genetic Variants and Cervical Abnormalities: The Ludwig-McGill Cohort Study. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, v. 28, n. 6, p. 1086-1088, JUN 2019. (08/57889-1)

FLORES-DIAZ, EMA; SEREDAY, KAREN A.; FERREIRA, SILVANEIDE; SIRAK, BRADLEY; SOBRINHO, JOAO SIMAO; BAGGIO, MARIA LUIZA; GALAN, LENICE; SILVA, ROBERTO C.; LAZCANO-PONCE, EDUARDO; GIULIANO, ANNA R.; et al. HPV-6 Molecular Variants Association With the Development of Genital Warts in Men: The HIM Study. Journal of Infectious Diseases, v. 215, n. 4, p. 559-565, FEB 15 2017. (08/57889-1)

LORENZI, ADRIANA TARLA; FREGNANI, JOSE HUMBERTO; VILLA, LUISA LINA; SICHERO, LAURA; NUNES, EMILY MONTOSA; LONGATTO-FILHO, ADHEMAR. Diversity of human papillomavirus typing among women population living in rural and remote areas of Brazilian territory. PAPILLOMAVIRUS RESEARCH, v. 8, DEC 2019. (08/57889-1)

TERMINI, LARA; FREGNANI, JOSE H.; BOCCARDO, ENRIQUE; DA COSTA, WALTER H.; LONGATTO-FILHO, ADHEMAR; ANDREOLI, MARIA A.; COSTA, MARIA C.; LOPES, ADEMAR; DA CUNHA, ISABELA W.; SOARES, FERNANDO A.; et al. SOD2 immunoexpression predicts lymph node metastasis in penile cancer. BMC CLINICAL PATHOLOGY, v. 15, MAR 3 2015. (08/57889-1)

MANN PRADO, JOSE CARLOS; MONEZI, TELMA ALVES; AMORIM, ALINE TEIXEIRA; LINO, VANESCA; PALADINO, ANDRESSA; BOCCARDO, ENRIQUE. Human polyomaviruses and cancer: an overview. Clinics, v. 73, n. 1, 2018. (08/57889-1)

CARVALHO DA SILVA, ROBERTO JOSE; SUDENGA, STACI LYNN; SICHERO, LAURA; BAGGIO, MARIA LUIZA; GALAN, LENICE; CINTRA, RICARDO; TORRES, BENJI NELSON; STOLER, MARK; GIULIANO, ANNA REGINA; VILLA, LUISA LINA. HPV-related external genital lesions among men residing in Brazil. Brazilian Journal of Infectious Diseases, v. 21, n. 4, p. 376-385, JUL-AUG 2017. (08/57889-1)

MARIANO, VANIA SAMMARTINO; LORENZI, ADRIANA TARLA; SCAPULATEMPO-NETO, CRISTOVAM; STEIN, MAIRA DEGIOVANI; POSSATI RESENDE, JULIO CESAR; ANTONIAZZI, MARCIO; VILLA, LUISA LINA; LEVI, JOSE EDUARDO; LONGATTO-FILHO, ADHEMAR; TAVARES GUERREIRO FREGNANI, JOSE HUMBERTO. A Low-Cost HPV Immunochromatographic Assay to Detect High-Grade Cervical Intraepithelial Neoplasia. PLoS One, v. 11, n. 10, OCT 20 2016. (12/51221-4, 08/57889-1)

JOSÉ CARLOS MANN PRADO; TELMA ALVES MONEZI; ALINE TEIXEIRA AMORIM; VANESCA LINO; ANDRESSA PALADINO; ENRIQUE BOCCARDO. Human polyomaviruses and cancer: an overview. Clinics, v. 73, 2018-10-11. (08/57889-1)

TERMINI, LARA; BOCCARDO, ENRIQUE. Epithelial Organotypic Cultures: A Viable Model to Address Mechanisms of Carcinogenesis by Epitheliotropic Viruses. CURRENT TOPICS IN MEDICINAL CHEMISTRY, v. 18, n. 4, p. 246-255, 2018. (12/16059-1, 10/20002-0, 08/57889-1)

PRATI, BRUNA; ABJAUDE, WALASON DA SILVA; TERMINI, LARA; MORALE, MIRIAN; HERBSTER, SUELLEN; LONGATTO-FILHO, ADHEMAR; LIMA NUNES, RAFAELLA ALMEIDA; CORDOBA CAMACHO, LIZETH CAROLINA; RABELO-SANTOS, SILVIA HELENA; ZEFERINO, LUIZ CARLOS; et al. Three Prime Repair Exonuclease 1 (TREX1) expression correlates with cervical cancer cells growth in vitro and disease progression in vivo. SCIENTIFIC REPORTS, v. 9, JAN 23 2019. (08/57889-1, 10/20002-0, 13/27006-9, 12/16512-8, 11/14416-9)

SICHERO, LAURA; CAMPBELL, CHRISTINE M. PIERCE; FULP, WILLIAM; FERREIRA, SILVANEIDE; SOBRINHO, JOAO S.; BAGGIO, MARIA LUIZA; GALAN, LENICE; SILVA, ROBERTO C.; LAZCANO-PONCE, EDUARDO; GIULIANO, ANNA R.; et al. High genital prevalence of cutaneous human papillomavirus DNA on male genital skin: the HPV Infection in Men Study. BMC INFECTIOUS DISEASES, v. 14, DEC 9 2014. (10/15282-3, 08/57889-1)

SICHERO, L.; NYITRAY, A. G.; NUNES, E. M.; NEPAL, B.; FERREIRA, S.; SOBRINHO, J. S.; BAGGIO, M. L.; GALAN, L.; SILVA, R. C.; LAZCANO-PONCE, E.; et al. Diversity of human papillomavirus in the anal canal of men: the HIM Study. Clinical Microbiology and Infection, v. 21, n. 5, p. 502-509, MAY 2015. (10/15282-3, 08/57889-1)

DO BONFIM, CAROLINE MEASSO; SOBRINHO, JOAO SIMAO; NOGUEIRA, RODRIGO LACERDA; KUPPER, DANIEL SALGADO; PEREIRA VALERA, FABIANA CARDOSO; NOGUEIRA, MAURCIO LACERDA; VILLA, LUISA LINA; RAHAL, PAULA; SICHERO, LAURA. Differences in Transcriptional Activity of Human Papillomavirus Type 6 Molecular Variants in Recurrent Respiratory Papillomatosis. PLoS One, v. 10, n. 7, JUL 7 2015. (10/00029-0, 08/57889-1)

BETIOL, JULIO C.; SICHERO, LAURA; DE OLIVAL COSTA, HENRIQUE O.; DE MATOS, LEANDRO L.; ANDREOLI, MARIA A.; FERREIRA, SILVANEIDE; FARAJ, SHEILA F.; DE MELLO, EVANDRO S.; SOBRINHO, JOAO S.; BRANDAO, LENINE G.; et al. Prevalence of human papillomavirus types and variants and p16(INK4a) expression in head and neck squamous cells carcinomas in Sao Paulo, Brazil. INFECTIOUS AGENTS AND CANCER, v. 11, MAY 4 2016. (12/01513-9, 08/57889-1, 11/09616-9)

MORALE, MIRIAN GALLIOTE; ABJAUDE, WALASON DA SILVA; SILVA, ALINE MONTENEGRO; VILLA, LUISA LINA; BOCCARDO, ENRIQUE. HPV-transformed cells exhibit altered HMGB1-TLR4/MyD88-SARM1 signaling axis. SCIENTIFIC REPORTS, v. 8, FEB 22 2018. (14/21361-4, 10/20002-0, 11/14416-9, 08/57889-1, 08/03232-1)

NUNES, EMILY M.; LOPEZ, ROSSANA V. M.; SUDENGA, STACI L.; GHEIT, TARIK; TOMMASINO, MASSIMO; BAGGIO, MARIA L.; FERREIRA, SILVANEIDE; GALAN, LENICE; SILVA, ROBERTO C.; LAZCANO-PONCE, EDUARDO; et al. Concordance of Beta-papillomavirus across anogenital and oral anatomic sites of men: The HIM Study. VIROLOGY, v. 510, p. 55-59, OCT 2017. (13/01440-4, 13/20470-1, 15/12557-5, 08/57889-1)

SICHERO, LAURA; EL-ZEIN, MARIAM; NUNES, EMILY M.; FERREIRA, SILVANEIDE; FRANCO, EDUARDO L.; VILLA, LUISA L.; STUDY, LUDWIG-MCGILL COHORT. Cervical Infection with Cutaneous Beta and Mucosal Alpha Papillomaviruses. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, v. 26, n. 8, p. 1312-1320, AUG 2017. (13/01440-4, 13/20470-1, 08/57889-1)

LORENZI, ADRIANA TARLA; FREGNANI, JOSE HUMBERTO T. G.; POSSATI-RESENDE, JULIO CESAR; NETO, CRISTOVAM SCAPULATEMPO; VILLA, LUISA LINA; LONGATTO-FILHO, ADHEMAR. Self-collection for high-risk HPV detection in Brazilian women using the caFeHPV (TM) test. GYNECOLOGIC ONCOLOGY, v. 131, n. 1, p. 131-134, OCT 2013. (08/57889-1)

SICHERO, LAURA; CAMPBELL, CHRISTINE M. PIERCE; FERREIRA, SILVANEIDE; SOBRINHO, JOAO S.; BAGGIO, MARIA LUIZA; GALAN, LENICE; SILVA, ROBERTO C.; LAZCANO-PONCE, EDUARDO; GIULIANO, ANNA R.; VILLA, LUISA L.; et al. Broad HPV distribution in the genital region of men from the HPV infection in men (HIM) study. VIROLOGY, v. 443, n. 2, p. 214-217, SEP 1 2013. (10/15282-3, 08/57889-1)

TAVARES GUERREIRO FREGNANI, JOSE HUMBERTO; CARVALHO, ANDRE LOPES; ELUF-NETO, JOSE; BRAGA RIBEIRO, KARINA DE CASSIA; KUIL, LARISSA DE MELO; DA SILVA, TAUANA ARCADEPANI; RODRIGUES, SILVIA LAPOLA; MAUAD, EDMUNDO CARVALHO; LONGATTO-FILHO, ADHEMAR; VILLA, LUISA LINA. A School-Based Human Papillomavirus Vaccination Program in Barretos, Brazil: Final Results of a Demonstrative Study. PLoS One, v. 8, n. 4, APR 24 2013. (08/57889-1)

ADUM DE MATOS, RENATA PRANDINI; SICHERO, LAURA; MANSUR, ISABELA MAZUCO; DO BONFIM, CAROLINE MEASSO; BITTAR, CINTIA; NOGUEIRA, RODRIGO LACERDA; KUEPPER, DANIEL SALGADO; PEREIRA VALERA, FABIANA CARDOSO; NOGUEIRA, MAURICIO LACERDA; VILLA, LUISA LINA; et al. Nucleotide and phylogenetic analysis of human papillomavirus types 6 and 11 isolated from recurrent respiratory papillomatosis in Brazil. INFECTION GENETICS AND EVOLUTION, v. 16, p. 282-289, JUN 2013. (08/57889-1)

DE ARAUJO-SOUZA, PATRICIA SAVIO; EL-ZEIN, MARIAM; BOLPETTI, ALINE DO N.; MACIAG, PAULO CESAR; RABACHINI, TATIANA; FRANCO, EDUARDO L.; VILLA, LUISA L.. Association Between Human Leukocyte Antigen Polymorphism and Human Papillomavirus Infection in Brazilian Women. SEXUALLY TRANSMITTED DISEASES, v. 50, n. 1, p. 9-pg., 2023-01-01. (08/57889-1)

HERBSTER, SUELLEN; TROMBETTA-LIMA, MARINA; DE SOUZA-SANTOS, PAULO THIAGO; PALADINO, ANDRESSA; SILVEIRA, CAIO RAONY FARINA; SOGAYAR, MARI CLEIDE; VILLA, LUISA LINA; LEPIQUE, ANA PAULA; BOCCARDO, ENRIQUE. Low RECK Expression Is Part of the Cervical Carcinogenesis Mechanisms. CANCERS, v. 13, n. 9, MAY 2021. (08/57889-1, 17/02997-3, 10/20002-0, 13/27006-9)

G.A. GRAZIA; D.R. BASTOS; L.L. VILLA. CD40/CD40L expression and its prognostic value in cervical cancer. Brazilian Journal of Medical and Biological Research, v. 56, 2023-11-13. (08/57889-1)