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Phenotypic characterization of circadian rhythms in different genotype individuals for clock gene polymorphisms in different regions in Brazil: an emphasis on the effect of the gene PER3 and latitude

Grant number: 11/05804-5
Support Opportunities:Regular Research Grants
Start date: December 01, 2012
End date: November 30, 2015
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Mario Pedrazzoli Neto
Grantee:Mario Pedrazzoli Neto
Host Institution: Escola de Artes, Ciências e Humanidades (EACH). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers: Guilherme Silva Umemura ; Luiz Silveira Menna Barreto ; Mário André Leocadio Miguel

Abstract

The PER3 gene is part of the molecular circadian system and it is involved in regulation of these biological rhythms, as for example, the adaptation to the light/dark cycle. The HIOMT and AANAT genes codify enzymes that are part of the melatonin synthesis pathways, whose production is associated with the light/dark cycle environment. Recent studies show associations with these three genes with so-called chronotypes and circadian rhythms disorders. Data from our own research group make us to hypothesize that these genes should have a role in the adaptation to different conditions of light/dark given by latitude. In this way aiming to test the hypothesis of differential regulation of circadian rhythms dependent on genotype and latitude we intend, in the present project, to analyze circadian rhythms of temperature and activity/rest of students genotyped for the PER3, HIOMIT and AANAT in three latitudes in Brazil, São Paulo, Alagoas and Rio Grande do Sul at two epochs around the year; winter and summer solstices (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (19)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SABINOA, FLAVIA CAL; DE OLIVEIRA, JOSE AMERICO; PEDRAZZOLI, MARIO. Per3 expression in different tissues of Cebus apella. SLEEP SCIENCE, v. 9, n. 4, SI, p. 262-265, . (11/05804-5)
VON SCHANTZ, MALCOLM; TAPOROSKI, TAMARA P.; HORIMOTO, ANDREA R. V. R.; DUARTE, NUBIA E.; VALLADA, HOMERO; KRIEGER, JOSE E.; PEDRAZZOLI, MARIO; NEGRAO, ANDRE B.; PEREIRA, ALEXANDRE C.. Distribution and heritability of diurnal preference (chronotype) in a rural Brazilian family-based cohort, the Baependi study. SCIENTIFIC REPORTS, v. 5, . (13/17368-0, 11/05804-5)
LEOCADIO-MIGUEL, MARIO ANDRE; LOUZADA, FERNANDO MAZZILI; DUARTE, LEANDRO LOURENCAO; AREAS, ROBERTA PEIXOTO; ALAM, MARILENE; FREIRE, MARCELO VENTURA; FONTENELE-ARAUJO, JOHN; MENNA-BARRETO, LUIZ; PEDRAZZOLI, MARIO. Latitudinal cline of chronotype. SCIENTIFIC REPORTS, v. 7, . (11/05804-5)
GEOVANINI, GLAUCYLARA REIS; VASQUES, ENIO RODRIGUES; ALVIM, RAFAEL DE OLIVEIRA; MILL, JOSE GERALDO; ANDREAO, RODRIGO VAREJAO; VASQUES, BRUNA KIM; PEREIRA, ALEXANDRE COSTA; KRIEGER, JOSE EDUARDO. Age and Sex Differences in Heart Rate Variability and Vagal Specific Patterns - Baependi Heart Study. GLOBAL HEART, v. 15, n. 1, . (13/17368-0, 11/05804-5)
PANJEH, SAREH; POMPEIA, SABINE; ARCHER, SIMON N.; PEDRAZZOLI, MARIO; VON SCHANTZ, MALCOLM; COGO-MOREIRA, HUGO. What are we measuring with the morningness-eveningness questionnaire? Exploratory factor analysis across four samples from two countries. CHRONOBIOLOGY INTERNATIONAL, v. 38, n. 2, p. 234-247, . (11/05804-5, 13/17368-0)
GEOVANINI, GLAUCYLARA REIS; DE SOUSA, IGUARACY PINHEIRO; TEIXEIRA, SAMANTHA KUWADA; FRANCISCO NETO, MIGUEL JOSE; GOMEZ GOMEZ, LUZ MARINA; DEL GUERRA, GUILHERME CICONELLI; PEREIRA, ALEXANDRE COSTA; KRIEGER, JOSE EDUARDO. Carotid intima-media thickness and metabolic syndrome in a rural population: Results from the Baependi Heart Study. INTERNATIONAL JOURNAL CARDIOLOGY HYPERTENSION, v. 6, . (11/05804-5, 13/17368-0)
PEDRAZZOLI, MARIO; MAZZOTTI, DIEGO ROBLES; RIBEIRO, AMANDA OLIVEIRA; MENDES, JULIANA VIANA; BITTENCOURT, LIA RITA AZEREDO; TUFIK, SERGIO. A single nucleotide polymorphism in the HOMER1 gene is associated with sleep latency and theta power in sleep electroencephalogram. PLoS One, v. 15, n. 7, . (11/05804-5, 98/14303-3)
DE ARAUJO, LAURA BRUNA GOMES; BIANCHIN, SANDIELI; PEDRAZZOLI, MARIO; LOUZADA, FERNANDO M.; BEIJAMINI, FELIPE. Multiple positive outcomes of a later school starting time for adolescents. SLEEP HEALTH, v. 8, n. 5, p. 7-pg., . (11/05804-5)
SABINOA, FLAVIA CAL; DE OLIVEIRA, JOSE AMERICO; PEDRAZZOLI, MARIO. Per3 expression in different tissues of Cebus apella. SLEEP SCIENCE, v. 9, n. 4, p. 4-pg., . (11/05804-5)
VON SCHANTZ, M.; TAPOROSKI, T.; HORIMOTO, A.; ESTEBAN, N.; VALLADA, H.; KRIEGER, J.; PEDRAZZOLI, M.; NEGRAO, A.; PEREIRA, A.. Distribution and heritability of diurnal preference (chronotype) in a rural Brazilian family-based cohort, the Baependi study. Sleep Medicine, v. 16, p. 2-pg., . (11/05804-5, 13/17368-0)
AHMED, S. S.; TAPOROSKI, T. P.; BEIJAMINI, F.; NEGRAO, A.; KRIEGER, J. E.; KNUTSON, K. L.; PEREIRA, A. C.; STERR, A.; VON SCHANTZ, M.. Insomnia in the Baependi heart cohort study. Journal of Sleep Research, v. 27, p. 1-pg., . (11/05804-5, 13/17368-0)
LEOCADIO-MIGUEL, MARIO ANDRE; CARNEIRO, BRENO TERCIO; XIMENES-DA-SILVA, ADRIANA; CAUMO, WOLNEI; GRASSI-KASSISSE, DORA; PEDRAZZOLI, MARIO. PER3 gene regulation of sleep-wake behavior as a function of latitude. SLEEP HEALTH, v. 4, n. 6, SI, p. 572-578, . (11/05804-5)
LEOCADIO-MIGUEL, MARIO A.; RUIZ, FRANCIELI S.; AHMED, SABRINA S.; TAPOROSKI, TAMARA P.; HORIMOTO, ANDREA R. V. R.; BEIJAMINI, FELIPE; PEDRAZZOLI, MARIO; KNUTSON, KRISTEN L.; PEREIRA, ALEXANDRE C.; VON SCHANTZ, MALCOLM. Compared Heritability of Chronotype Instruments in a Single Population Sample. JOURNAL OF BIOLOGICAL RHYTHMS, v. 36, n. 5, . (11/05804-5)
GEOVANINI, GLAUCYLARA REIS; LORENZI-FILHO, GERALDO; DE PAULA, LILIAN K.; OLIVEIRA, CAMILA MACIEL; ALVIM, RAFAEL DE OLIVEIRA; BEIJAMINI, FELIPE; NEGRAO, ANDRE BROOKING; VON SCHANTZ, MALCOLM; KNUTSON, KRISTEN L.; KRIEGER, JOSE EDUARDO; et al. Poor sleep quality and lipid profile in a rural cohort (The Baependi Heart Study). Sleep Medicine, v. 57, p. 30-35, . (11/05804-5, 13/17368-0)
NASCIMENTO DE ALENCAR, JOAO CARLOS; LEOCADIO-MIGUEL, MARIO ANDRE; DUARTE, LEANDRO LOURENCAO; LOUZADA, FERNANDO; ARAUJO, JOHN FONTENELE; PEDRAZZOLI, MARIO. Self-reported discomfort associated with Daylight Saving Time in Brazilian tropical and subtropical zones. ANNALS OF HUMAN BIOLOGY, v. 44, n. 7, p. 628-635, . (11/05804-5)
A.A. BARBOSA; M.A.L. MIGUEL; S. TUFIK; F.C. SABINO; M.S. CENDOROGLO; M. PEDRAZZOLI. Sleep disorder or simple sleep ontogeny? Tendency for morningness is associated with worse sleep quality in the elderly. Brazilian Journal of Medical and Biological Research, v. 49, n. 10, . (11/05804-5, 98/14303-3)
EGAN, KIEREN J.; VON SCHANTZ, MALCOLM; NEGRAO, ANDRE B.; SANTOS, HADASSA C.; HORIMOTO, ANDREA R. V. R.; DUARTE, NUBIA E.; GONCALVES, GUILHERME C.; SOLER, JULIA M. P.; DE ANDRADE, MARIZA; LORENZI-FILHO, GERALDO; et al. Cohort profile: the Baependi Heart Study - a family-based, highly admixed cohort study in a rural Brazilian town. BMJ OPEN, v. 6, n. 10, . (13/17368-0, 11/05804-5)
TEIXEIRA, BRUNO SIMAO; SILVA, CATARINA MENDES; SILVA, ALINNE TATIANE FARIA; SANTOS, LETICIA LOPES DANTAS; MAIA, YARA CRISTINA DE PAIVA; PEDRAZZOLI, MARIO; WRIGHT JR, KENNETH P. P.; CRISPIM, CIBELE APARECIDA. Influence of fasting during the night shift on next day eating behavior, hunger, and glucose and insulin levels: a randomized, three-condition, crossover trial. EUROPEAN JOURNAL OF NUTRITION, v. N/A, p. 13-pg., . (11/05804-5)
LEOCADIO-MIGUEL, MARIO ANDRE; CARNEIRO, BRENO TERCIO; XIMENES-DA-SILVA, ADRIANA; CAUMO, WOLNEI; GRASSI-KASSISSE, DORA; PEDRAZZOLI, MARIO. PER3 gene regulation of sleep-wake behavior as a function of latitude. SLEEP HEALTH, v. 4, n. 6, p. 7-pg., . (11/05804-5)