Jacqueline Mendonça Lopes de Faria

• Abstract

  In this PIPE phase 1 proposal, the company VERLUX intends to acquire the inputs (high purity raw material) in sufficient quantities for the production of 750 ml of the ophthalmic solution (eye drops) with the participation of a technician from the field of nanopharmacology (TT3) in exclusive dedication, by consultant Dr. Claudia Regina and researcher Dr. Jacqueline M Lopes de Faria (respo…

  Production of an ophthalmic topic nanostructured solution (eye drop) batch to treat diabetic retinopathy: a new paradigm, AP.PIPE

• Abstract

  The proliferative retinopathy is a common cause of irreversible visual loss. It occurs in advanced diabetic retinopathy, central vein occlusion and also in oxygen induced retinopathy, as seen in retinopathy of prematurity. Up to now, the treatment for these diseases is invasive, involving laser photocoagulation, intravitreous injection of anti-VEGF agents or vitrectomy. To develop new the…

  Mechanisms underlying the ischemic retinal neovascularization: an in vivo and in vitro study, AP.R

• Abstract

  Possible protection of Early Outgrow Cells (EOCs) in retina from diabetic mice: possible role of SIRT-1 in Müller Cells. (AU)

  Possible protective effects of Early Outgrow Cells (EOCs) of diabetic retina from db/db mice: the possible role of SIRT-1 in retina Müller cells, AP.R

(Only some records are available in English at this moment)

• Abstract

  Diabetes Mellitus (DM) is a disease characterized by Chronic Hyperglycemia and is associated with damage to several organs. Diabetic Retinopathy (DR) is a chronic complication of DM characterized by a premature and progressive neurological impairment that affects neural cells, glial cells, vascular elements and is considered one of the major causes of blindness in working age around the w…

  Involvement of AMPK in the retina of AMPK Knockout mice in experimental models of Diabetes and Proliferative Ischemic Retinopathy: in vivo and in vitro, BP.DR
• Mechanisms underlying the ischemic retinal neovascularization: an in vivo and in vitro study, BP.TT

• Abstract

  The diabetic retinopathy (RD) is a chronic complication characterized by the degeneration of the neurons, glial cells and accompanied by extensive microvascular dysfunction in the retina. However, several biochemical evidences were described associates to the toxicity for hyperglycemia in retinal cells, among them oxidative stress. The oxidative stress was already described as pivotal in …

  MODULATION OF GLUTAMATERGIC AND PURINERGIC PATHWAY IN PRIMARY NEURONAL CELLS OF RETINA IN DIABETIC MICE AND THEIR CONTROLS NOT DIABETICS: Study in vitro of possible antioxidant mechanisms in the neuroproteção of retina., BP.PD