CV Lattes
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Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Farmácia e Bioquímica from Universidade Federal de Santa Catarina (1981), master's at Pharmacy from Universidade de São Paulo (1990) and doctorate at Parasitology from Universidade de São Paulo (1998). Has experience in Microbiology, focusing on Microbiology, acting on the following subjects: detecção, e. coli diarreiogênica, epec, imunodiagnóstico and anticorpos monoclonais. (Source: Lattes Curriculum)
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Hemolytic Uremic Syndrome (HUS) is an acute and potentially fatal condition, often triggered by Shiga toxin produced by Escherichia coli. Characterized by severe complications such as thrombocytopenia, microangiopathic hemolytic anemia, and acute kidney failure, HUS is most commonly observed in children. A promising therapeutic approach to neutralize the adverse effects of Shiga toxin is …
(Only some records are available in English at this moment)
Hemolytic uremic syndrome (HUS) is a severe and potentially fatal condition frequently associated with Escherichia coli strains that produce Shiga toxin. It is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure, and is most prevalent in children. Among the promising therapeutic approaches to neutralize the effects of this toxin are antibody fragm…
Toxin-antitoxin systems are genetic modules composed of a labile antitoxin that inhibits a stable toxin and are associated with some physiological processes of bacteria, such as the formation of persistent cells, biofilm formation, protection against bacteriophages and responses to stressful environments. In these modules, the toxin is related to the inhibition of physiological processes …
Toxin-antitoxin (TA) systems are genetic modules that are widespread in prokaryotes and archaea. On the chromosome, these systems may be involved in several virulence factors of pathogenic bacteria. In E. coli K12, 36 TA systems have been described, of which type II is the most abundant and studied. Within the scope of E. coli that cause diarrhea, the STEC pathotype stands out as one of t…
(Only some records are available in English at this moment)
Toxin-antitoxin (TA) systems are genetic modules that play critical roles in bacterial stress responses, virulence, and survival under adverse conditions. In Escherichia coli, particularly hybrid strains that combine virulence traits from multiple pathotypes, such as BA1250 in which the functions of TA systems remain poorly characterized. This project focuses on investigating two type II …
Uropathogenic Escherichia coli (UPEC) are the main cause of urinary tract infection (UTI). Among the virulence factors produced by UPEC, alpha-hemolysin (HlyA) and cytotoxic necrotizing factor 1 (CNF1) stand out. These toxins become good targets for diagnosis and therapeutic interventions, once there is a need for a rapid and sensitive diagnostic method, as well as new therapies, which al…
Shiga toxin-producing Escherichia coli is responsible for hemorrhagic colitis and hemolytic-uremic syndrome, which aggravates the condition of the infected patients. The diagnosis of this pathogen is not included in routine laboratories in developing countries. The development of tools for detecting these toxins becomes very relevant to their diagnosis. Antibodies have proven to be an exc…
| 1 / 1 | Ongoing grants |
| 31 / 18 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 36 / 20 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 72 / 43 | All research grants and scholarships |
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