CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas from Universidade Estadual Paulista Júlio de Mesquita Filho (1992), master's at General Biology from Universidade Estadual de Campinas (1994) and doctorate at Biochemistry from Universidade Estadual de Campinas (1998). Has experience in Pharmacy, focusing on Pharmacy, acting on the following subjects: cultura de células, matriz extracelular, melanoma, crescimento tumoral and invasion and metastasis. (Source: Lattes Curriculum)
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Biological research of the skin, the study of human skin diseases, and various clinical and pharmaceutical applications rely on skin models known for their reproducibility and predictability. Traditionally, these models have included animals, primarily rodents, and cell cultures. However, due to ethical considerations and recent technological advancements, human cell models are gradually …
Microenvironment and transcriptional plasticity generate subpopulations within the tumor and the use of BRAF inhibitors (BRAFi) contributes to the arising and selection of resistant clones. We stochastically isolated subpopulations (C1, C2 and C3) from naïve melanoma and found that the clones demonstrated distinct morphology, phenotypic and functional profiles: C1 was less prolif-erative,…
Chronic wounds affect a significant portion of the global population, particularly older adults with underlying health complications such as diabetes. The complex pathophysiology of chronic wounds involves persistent inflammation, reduced growth factor expression, and potential bacterial biofilm formation. Current treatment options lack specificity and face challenges posed by antimicrobi…
(Only some records are available in English at this moment)
Melanoma, which originates from the malignant transformation of melanocytes, is considered the most aggressive type of skin cancer with a high mortality rate, particularly due to the limitations of current treatments and early resistance. In this context, synthetic lethality (SL) emerges as a promising approach, based on inducing cell death through the simultaneous inhibition of two relat…
Melanoma is considered the most aggressive type of skin cancer and the one with the worst prognosis because of its high metastatic and proliferative capacity. Its carcinogenic process is related to the emergence of mutations on somatic genes related to cell cycle control, especially the MAPK pathway, in which BRAFV600E is the most frequent mutation. The development of immunotherapy and ta…
Aging is the most significant demographic risk factor for cancer development, indicating that molecular changes during the process are a trigger for malignant transformation. Melanoma is a cancer with a high probability of metastasis and a high rate of resistance to conventional therapies, resulting in a worse prognosis especially for the elderly. Physiological processes such as the accum…
Melanoma is the most lethal type of skin cancer, characterized by its high metastatic potential. The MAPK pathway, frequently activated by mutations in BRAF(V600E), plays a central role in its pathogenesis. Despite significant progress with BRAF inhibitors and immunotherapies, treatment resistance amplified by intra-tumoral heterogeneity underscores the urgent need for new biomarkers and …
Melanogenesis is a complex and multifactorial process that is determinant for the safety of the skin against solar radiation. Inside melanocytes, the epidermal cells responsible for the melanin synthesis, melanossomes do the process with the transcription of key enzymes by the microphtalmia-associated transcription factor, conversion of L-tyrosine in dopaquinone by tyrosinase and subseque…
Due to its metastatic and highly proliferative capacity, melanoma is the skin cancer with the highest mortality rate, although it is a minor incident. This scenario is mainly due to the waiting aspect in the MAPK pathway, mainly in the BRAFV600E protein, which exacerbates signals of growth, survival, invasion, and blocking of cell death. In this sense, the development of BRAF inhibitors (…
(Only some records are available in English at this moment)
Melanoma is the most lethal type of skin cancer because it is more metastatic and has a high rate of resistance to conventional therapies, which results in a worse prognosis, especially in the elderly. About 50% of melanoma casa involve a mutation in the BRAF gene, in which valine is replaced by glutamic acid at codon 600. In melanoma there is a reduction in Hippo pathway signaling and th…
Melanoma arises from melanocytes transformed from the basal lamina of the dermal-epidermal junction and harbor a remarkable proliferation, metastasis, and immune evasion capacity propelling a patient's poor prognosis. Among other types of melanomas, acral lentiginous melanoma (ALM) is a rare subtype that appears in the palm, soles, and nail bed areas, most in non-white patients. Regardles…
Colorectal cancer (CRC) remains a major public health issue. The evolutionary events that cause colorectal localized tumors to progress to metastasis remain mostly unknown. Chromosomal alterations seem to be important in the chain of events that leads to the development of CRC that cooperate with mutations of well-described tumor-associated mutations such as APC, KRAS and p53. Furthermore…
(Only some records are available in English at this moment)