Development of a microarray platform for the detection of roboviruses and arboviruses

• Grant number: 11/02045-6
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: July 01, 2011
• End date: September 30, 2014
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Principal Investigator: Victor Hugo Aquino Quintana
• Grantee: Mohd Jaseem Khan
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Brazil is a large tropical country (8,514,215 km2) with 190,732,694 inhabitants. More than one of third of its territory is covered by tropical forest or other natural ecosystems, which provide ideal conditions for the existence of many roboviruses (virus transmitted by rodents) and arboviruses (viruses transmitted by arthropods), which are maintained in a large variety of zoonotic cycles. Members of roboviruses and arboviruses have several characters representing an emerging threat to public health worldwide, especially in tropical countries. Brazil is the country where the largest number of arboviruses was found in the world. Roboviruses and arboviruses causing diseases in humans in Brazil mainly belong to five families: Arenaviridae, Bunyaviridae, Flaviviridae, Rhabdoviridae and Togaviridae. Considering the public health significance of some of the roboviruses and arboviruses present in Brazil and the possible emergence of other viruses, there is a great interest to develop rapid diagnostic methods for specific viruses. The fast recognition of an infectious agent during epidemics may allow specific interventions that would allow reduction of morbidity and mortality. The DNA microarray technology is a new diagnostic tool that allows the detection of a large number of viral agents simultaneously. This technology could be very important in Brazil for rapid identification of viruses responsible for outbreaks and possible emerging viruses. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KHAN, MOHD JASEEM; TRABUCO, AMANDA CRISTINA; ALFONSO, HELDA LIZ; FIGUEIREDO, MARIO LUIS; BATISTA, WEBER CHELI; BADRA, SORAYA JABUR; FIGUEIREDO, LUIZ TADEU; LAVRADOR, MARCO AURELIO; AQUINO, VICTOR HUGO. DNA Microarray Platform for Detection and Surveillance of Viruses Transmitted by Small Mammals and Arthropods. PLoS Neglected Tropical Diseases, v. 10, n. 9, SEP 2016. (11/02045-6, 08/50617-6)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

KHAN, Mohd Jaseem. Development of a DNA microarray platform for the detection of viruses transmitted by small mammals and arthropods. 2015. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.