| Grant number: | 16/15021-1 |
| Support Opportunities: | Research Grants - Research in Public Policies for the National Health Care System (PP-SUS) |
| Start date: | December 01, 2016 |
| End date: | November 30, 2018 |
| Field of knowledge: | Biological Sciences - Microbiology - Biology and Physiology of Microorganisms |
| Agreement: | CNPq - PPSUS |
| Principal Investigator: | Maurício Lacerda Nogueira |
| Grantee: | Maurício Lacerda Nogueira |
| Host Institution: | Faculdade de Medicina de São José do Rio Preto (FAMERP). São José do Rio Preto , SP, Brazil |
| City of the host institution: | São José do Rio Preto |
| Associated researchers: | Cinara de Cássia Brandão ; Denise Cristina Mós Vaz Oliani ; Eliana Márcia Sotello Cabrera ; Luiz Carlos de Mattos |
Abstract
The Zika virus infection epidemic in Brazil is one of the most important challenges of contemporary Brazilian science. The first cases of microcephaly potentially associated with this virus have been reported in northeastern Brazil. Between August and October 2015 dozens of cases of microcephaly and ocular abnormalities were observed in newborns and laboratory tests in their blood and tissues as well as their mothers demonstrated the presence of Zika virus. In this context, it is assumed that the state of São Paulo and especially its regions with large infestation of Aedes aegypti (for example, the region of São José do Rio Preto, in northwestern São Paulo) are not exempt from virus transmission risk Zika and potential clinical complications resulting from infection by this arbovirus. Thus, the aim of this work is to develop a prospective cohort (already in progress) of infected pregnant women in order to evaluate the clinical, virological and epidemiological aspects of Zika infection in pregnant women and their offsprings. In particular we propose: i) verify the incidence of serious outcomes (such as microcephaly) in pregnant women infected with confirmed Zika virus infection and its relationship with periods of infection; ii) to verify the incidence of mild outcomes (not clinically apparent) through imaging methods in children from infected mothers; iii) determine the incidence of congenital infection in fetuses from mothers with confirmed ZIka infection by PCR in cord blood, urine and / or serology in the fetus; iv) Check the relative and absolute risk of minor, serious and virological outcomes; v) In collaboration with other studies, verify the virological, immunological and epidemiological aspects and their relationship with the outcome. The resulting studies of this work can help the SUS implement control policies, surveillance, harm reduction and health planning. (AU)
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