| Grant number: | 14/10068-4 |
| Support Opportunities: | Multi-user Equipment Program |
| Start date: | September 01, 2014 |
| End date: | August 31, 2016 |
| Field of knowledge: | Biological Sciences - Biochemistry - Chemistry of Macromolecules |
| Principal Investigator: | Daniel Martins-de-Souza |
| Grantee: | Daniel Martins-de-Souza |
| Host Institution: | Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
| City of the host institution: | Campinas |
| Associated research grant: | 13/08711-3 - Developing a predictive test for a successful medication response and understanding the molecular bases of schizophrenia through proteomics, AP.JP |
| As informações de acesso ao Equipamento Multiusuário são de responsabilidade do Pesquisador responsável | |
| EMU web page: | Página do Equipamento Multiusuário não informada |
| Type of equipment: | Caracterização de Materiais - Análises Químicas - Cromatografia líquida acoplada a espectrômetro de massa |
| Manufacturer: | Fabricante não informado |
| Model: | Modelo não informado |
Abstract
A mass spectrometer is the central core of a proteomics laboratory. Proteomic analyses depend 100% on a mass spectrometer. The equipment proposed is pivotal for the success of the project 13/08711-3 funded by FAPESP. All steps proposed by this project as well as collaborations regarding proteomic analyses in all senses depend heavily on this equipment: protein identification, quantification, top-down proteomics, and large-scale studies of post-translation modifications. Moreover, metabolomics is one more area intended to be covered by this equipment in the long run. The proposed system was chosen based in its capacity of measuring samples in a data independent analyses manner. This is particularly important for clinical projects, since samples can be measured individually: more samples can be analyzed increasing the statistical power. Consequently, results go towards clinical applications. Also, the proteomes of interest can be quantified by a label-free approach, avoiding sample manipulation variations. Additionally, the ion mobility function favors the analyses of post-translational modifications while ETD (Electron-transfer dissociation) may favor top-down approaches. These functions broaden the range of collaborations, which is necessary for a multi-user equipment. (AU)
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