Evolution of changes in brain metabolism accross different stages of bipolar disorder

• Grant number: 12/11428-9
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2012
• End date: February 28, 2015
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: Elisa Brietzke
• Grantee: Elisa Brietzke
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Rodrigo Affonseca Bressan ; Rodrigo Barbachan Mansur

Abstract

Background: Metabolic abnormalities are common in individuals with bipolar disorder (BD) and are responsible for the high prevalence of diabetes and metabolic syndrome in this population. Several neurobiological systems related to energetic metabolism have been shown to be abnormal in BD. Recent theories postulated that the brain regulates its own nutrient supply. Hypothesis: metabolic abnormalities observed in BD result of an unefficient of energetic brain supply and its compensatory responses. Objectives: Investigate energetic metabolism of individuals with BD accross illness evolution. Methods: Case-control study comparing 3 groups: 30 patients with BD with less than 5 years of evolution, 30 patients with BD with more than 10 years of evolution and 30 healthy controls. All the subjects will be submitted to psychiatric interview. Blood samples will be obtained for analysis of biomarkers related to neuroplasticity, astrocitary function, glucose metabolism, oxidative stress, stress response, lipids and regulatory hormones. Clinical importance: The proposed study is the first to involve a comprehensive and integrated platform of energetic metabolism. If differences in energetic metabolism were found accross stages, this study will open new avenues for research in pathophysiology of BD and development of new and efficient therapeutic strategies. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MANSUR, RODRIGO B.; RIZZO, LUCAS B.; SANTOS, CAMILA M.; ASEVEDO, ELSON; CUNHA, GRACCIELLE R.; NOTO, MARIANE N.; PEDRINI, MARIANA; ZENI-GRAIFF, MAIARA; GOUVEA, EDUARDO S.; CORDEIRO, QUIRINO; et al. Bipolar disorder course, impaired glucose metabolism and antioxidant enzymes activities: A preliminary report. JOURNAL OF PSYCHIATRIC RESEARCH, v. 80, p. 38-44, SEP 2016. (12/11428-9)

LECLERC, EMILIE; MANSUR, RODRIGO B.; GRASSI-OLIVEIRA, RODRIGO; CORDEIRO, QUIRINO; KAPCZINSKI, FLAVIO; MCINTYRE, ROGER S.; BRIETZKE, ELISA. The differential association between history of childhood sexual abuse and body mass index in early and late stages of bipolar disorder. Journal of Affective Disorders, v. 227, p. 214-218, FEB 2018. (12/11428-9)