Morphoanatomical, metabolomic and molecular studies as subsidies to the systematic of Asteraceae species and access to their pharmacological potential

• Grant number: 10/51454-3
• Support Opportunities: Research Projects - Thematic Grants
• Start date: August 01, 2011
• End date: July 31, 2017
• Field of knowledge: Biological Sciences - Botany
• Principal Investigator: Beatriz Appezzato da Glória
• Grantee: Beatriz Appezzato da Glória
• Host Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
• Pesquisadores principais: Fernando Batista da Costa
• Associated scholarship(s): 14/01707-3 - Metabolomic analysis of the bioactivity in COX and LOX pathways-dependent of plants from subtribe Lychnophorinae, BP.MS; 12/16646-4 - Metabolomics and screening of plant-insect interactions of plants from the subtribe Lychnophorinae (Asteraceae), BP.DR; 12/10249-3 - Chemometrics applied to metabolomics of Aldama La Llave: chemotaxonomic contributions and targeted phytochemistry based on cyclooxygenase-1 and 5-lipoxygenase inhibition, BP.MS

Abstract

The thematic project is organized in three subprojects whose main goal is to broaden metabolomic and morphoanatomical knowledge of Asteraceae clarifying the phylogeny of two major groups, besides investigating the pharmacological potential of the species through in vitro bioassays. The choice of Heliantheae and Vemonieae tribes was based on the fact that they are quite representative groups in Brazil in two very distinct branches within Asteraceae. Many of the species are endemic, occurring in Cerrado areas, and at risk of being wiped out before biological and chemical studies are carried out. Viguiera Kunth. (Heliantheae tribe) was chosen since it has a high number of species, complex taxonomic classification and problems of delimitation. A taxonomic revision of the species occurring in Brazil was held in 2006 by Prof. Mara Magenta, who pointed out the need for studies using molecular markers associated with morphoanatomical and chemical studies to understand the phylogeny of this group. From the tribe Vernonieae species of the subtribe Lychnophorinae and a related monospecific genus, considered the sister group of Lychnophorinae, were selected. The choice was based on preliminary results of molecular phylogeny and the difficulty to design phylogenetic group by doctorate Benoit Loeuille under the supervision of Prof. Jose R. Pirani. The search for new chemical compounds from plants in major Brazilian biomes like Cerrado for their use in the treatment of diseases can contribute to the sustainability of the country, which could generate income in small communities of less-favored regions where the species listed in this project grow and develop. (AU)

Scientific publications

(40)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SOUZA DA SILVA, EDILMARA MICHELLY; HAYASHI, ADRIANA HISSAE; APPEZZATO-DA-GLORIA, BEATRIZ. Anatomy of vegetative organs in Aldama tenuifolia and A. kunthiana (Asteraceae: Heliantheae). BRAZILIAN JOURNAL OF BOTANY, v. 37, n. 4, p. 505-517, DEC 2014. (10/51454-3)

OLIVEIRA, TUANE; BOMBO, ALINE BERTOLOSI; APPEZZATO-DA-GLORIA, BEATRIZ. Anatomy of vegetative organs with an emphasis on the secretory structures of two species of Aldama (Asteraceae-Heliantheae). BOTANY, v. 91, n. 6, p. 335-342, JUN 2013. (10/02005-1, 10/51454-3)

LUSA, MAKELI GARIBOTTI; APPEZZATO-DA-GLORIA, BEATRIZ; LOEUILLE, BENOIT; BARTOLI, GIACOMO; CICCARELLI, DANIELA. Functional groups in Lychnophorinae (Asteraceae: Vernonieae) based on morphological and anatomical traits. Australian Journal of Botany, v. 62, n. 2, p. 150-163, 2014. (12/16071-1, 10/51454-3, 10/02085-5)

POLETI MARTUCCI, MARIA ELVIRA; LOEUILLE, BENOIT; PIRANI, JOSE RUBENS; GOBBO-NETO, LEONARDO. Comprehensive untargeted metabolomics of Lychnnophorinae subtribe (Asteraceae: Vernonieae) in a phylogenetic context. PLoS One, v. 13, n. 1, JAN 11 2018. (12/16646-4, 10/51454-3)

BOMBO, ALINE BERTOLOSI; FILARTIGA, ARINAWA LIZ; APPEZZATO-DA-GLORIA, BEATRIZ. Solving taxonomic problems within the Aldama genus based on anatomical characters. Australian Journal of Botany, v. 64, n. 6, p. 501-512, 2016. (12/02476-0, 12/01586-6, 10/51454-3)

BOMBO, ALINE BERTOLOSI; DE OLIVEIRA, TUANE SANTOS; SANTOS DE OLIVEIRA, ADRIANA DA SILVA; GARCIA REHDER, VERA LUCIA; APPEZZATO-DA-GLORIA, BEATRIZ. Anatomy and essential oil composition of the underground systems of three species of Aldama La Llave (Asteraceae). JOURNAL OF THE TORREY BOTANICAL SOCIETY, v. 141, n. 2, p. 115-125, APR 2014. (10/01931-0, 10/51454-3)

MARA ANGELINA GALVÃO MAGENTA; BENOIT LOEUILLE; JOSÉ RUBENS PIRANI. Fitogeografia de Aldama (Asteraceae, Heliantheae) na América do Sul. Rodriguésia, v. 68, n. 2, p. 463-480, 2017-06-00. (10/51454-3)

FILARTIGA, ARINAWA LIZ; BOMBO, ALINE BERTOLOSI; GARCIA, VERA LUCIA; APPEZZATO-DA-GLORIA, BEATRIZ. Leaf and stem anatomy and essential oil composition of four Brazilian Aldama species (Asteraceae) and their taxonomic significance. BRAZILIAN JOURNAL OF BOTANY, v. 40, n. 2, p. 503-516, JUN 2017. (12/02476-0, 12/01586-6, 10/51454-3)

BOMBO, A. B.; APPEZZATO-DA-GLORIA, B.; ASCHENBRENNER, A. -K.; SPRING, O.. Capitate glandular trichomes in Aldama discolor (Heliantheae - Asteraceae): morphology, metabolite profile and sesquiterpene biosynthesis. Plant Biology, v. 18, n. 3, p. 455-462, MAY 2016. (14/06851-5, 10/51454-3)

SOUZA, MARCELO CLARO; SCALON, MARINA CORREA; POSCHENRIEDER, CHARLOTTE; TOLRA, ROSER; VENANCIO, TIAGO; TEIXEIRA, SIMONE PADUA; DA COSTA, FERNANDO BATISTA. Mechanisms of storage and detoxification of Al in two tropical mistletoes. ENVIRONMENTAL AND EXPERIMENTAL BOTANY, v. 150, p. 37-45, JUN 2018. (13/21293-6, 14/26866-7, 10/51454-3)

DE SOUZA, MARCELO CLARO; ROSA, ANNYLORY LIMA; POSCHENRIEDER, CHARLOTTE; TOLRA, ROSER; DA COSTA, FERNANDO BATISTA. Fingerprinting metabolomics in tropical mistletoes: A case study with facultative aluminum-accumulating species. PHYTOCHEMISTRY LETTERS, v. 25, p. 90-94, JUN 2018. (13/21293-6, 14/26866-7, 10/51454-3)

FILARTIGA, ARINAWA LIZ; BASSINELLO, VANESSA; FILIPPI, GUSTAVO MORTEAN; BOMBO, ALINE BERTOLOSI; APPEZZATO-DA-GLORIA, BEATRIZ. Secretory duct distribution and leaf venation patterns of Aldama species (Asteraceae) and their application in taxonomy. BOTANY, v. 94, n. 12, p. 1161-1170, DEC 2016. (12/02476-0, 12/01586-6, 10/51454-3)

LUSA, MAKELI GARIBOTTI; CARDOSO, ELAINE CRISTINA; MACHADO, SILVIA RODRIGUES; APPEZZATO-DA-GLORIA, BEATRIZ. Trichomes related to an unusual method of water retention and protection of the stem apex in an arid zone perennial species. AOB PLANTS, v. 7, 2015. (10/51454-3, 10/02085-5)

BOMBO, MINE BERTOLOSI; DE OLIVEIRA, TUANE SANTOS; APPEZZATO-DA-GLORIA, BEATRIZ; DA LUZ COELHO NOVEMBRE, ANA DIONISIA. Seed germination of Brazilian Aldama species (Asteraceae). JOURNAL OF SEED SCIENCE, v. 37, n. 3, p. 185-191, JUL-SEP 2015. (10/01931-0, 10/51454-3)

MUNIZ, L. F.; BOMBO, A. B.; FILARTIGA, A. L.; APPEZZATO-DA-GLORIA, B.. Can climate and soil conditions change the morpho-anatomy among individuals from different localities? A case study in Aldama grandiflora (Asteraceae). Brazilian Journal of Biology, v. 78, n. 4, p. 12-pg., 2018-11-01. (12/01586-6, 12/02476-0, 10/51454-3)

CHAGAS-PAULA, DANIELA APARECIDA; OLIVEIRA, TIAGO BRANQUINHO; ZHANG, TONG; EDRADA-EBEL, RUANGELIE; DA COSTA, FERNANDO BATISTA. Prediction of Anti-inflammatory Plants and Discovery of Their Biomarkers by Machine Learning Algorithms and Metabolomic Studies. Planta Medica, v. 81, n. 6, p. 9-pg., 2015-04-01. (10/10940-2, 10/51454-3)

SOUZA DA SILVA, EDILMARA MICHELLY; HAYASHI, ADRIANA HISSAE; APPEZZATO-DA-GLORIA, BEATRIZ. Anatomy of vegetative organs in Aldama tenuifolia and A. kunthiana (Asteraceae: Heliantheae). Rev. bras. Bot., v. 37, n. 4, p. 13-pg., 2014-12-01. (10/51454-3)

CHAGAS-PAULA, DANIELA A.; ZHANG, TONG; DA COSTA, FERNANDO B.; EDRADA-EBEL, RUANGELIE. A Metabolomic Approach to Target Compounds from the Asteraceae Family for Dual COX and LOX Inhibition. METABOLITES, v. 5, n. 3, p. 404-430, SEP 2015. (10/10940-2, 10/51454-3)

MARA ANGELINA GALVÃO MAGENTA; JOSÉ RUBENS PIRANI. Novidades taxonômicas em Aldama (Asteraceae-Heliantheae). Rodriguésia, v. 65, n. 1, p. 175-192, 2014-03-00. (10/51454-3)

LUSA, MAKELI GARIBOTTI; PATRICE LOEUILLE, BENOIT FRANCIS; CICCARELLI, DANIELA; APPEZZATO-DA-GLORIA, BEATRIZ. Evolution of Stem and Leaf Structural Diversity: a Case Study in Lychnophorinae (Asteraceae). BOTANICAL REVIEW, v. 84, n. 3, p. 203-241, SEP 2018. (10/51454-3, 10/02085-5)

FILARTIGA, A. L.; BOMBO, A. B.; GARCIA, V. L.; APPEZZATO-DA-GLORIA, B.. Belowground organs of four Brazilian Aldama (Asteraceae) species: Morphoanatomical traits and essential oil profile. SOUTH AFRICAN JOURNAL OF BOTANY, v. 113, p. 150-159, NOV 2017. (12/02476-0, 12/01586-6, 10/51454-3)

PADILLA-GONZALEZ, GUILLERMO E.; DIAZGRANADOS, MAURICIO; DA COSTA, FERNANDO B.. Effect of the Andean Geography and Climate on the Specialized Metabolism of Its Vegetation: The Subtribe Espeletiinae (Asteraceae) as a Case Example. METABOLITES, v. 11, n. 4, APR 2021. (16/21183-4, 14/17702-0, 14/26866-7, 10/51454-3)

LOEUILLE, BENOIT; THODE, VERONICA; SINISCALCHI, CAROLINA; ANDRADE, SONIA; ROSSI, MAGDALENA; PIRANI, JOSE RUBENS. Extremely low nucleotide diversity among thirty-six new chloroplast genome sequences from Aldama (Heliantheae, Asteraceae) and comparative chloroplast genomics analyses with closely related genera. PeerJ, v. 9, FEB 24 2021. (10/51454-3)

MUNIZ, L. F.; BOMBO, A. B.; FILARTIGA, A. L.; APPEZZATO-DA-GLORIA, B.. Can climate and soil conditions change the morpho-anatomy among individuals from different localities? A case study in Aldama grandiflora (Asteraceae). Brazilian Journal of Biology, v. 78, n. 4, p. 706-717, NOV 2018. (10/51454-3, 12/01586-6, 12/02476-0)

CHAGAS-PAULA, DANIELA APARECIDA; OLIVEIRA, TIAGO BRANQUINHO; ZHANG, TONG; EDRADA-EBEL, RUANGELIE; DA COSTA, FERNANDO BATISTA. Prediction of Anti-inflammatory Plants and Discovery of Their Biomarkers by Machine Learning Algorithms and Metabolomic Studies. Planta Medica, v. 81, n. 6, SI, p. 450-458, APR 2015. (10/10940-2, 10/51454-3)

FILARTIGA, ARINAWA LIZ; KLIMESOVA, JITKA; APPEZZATO-DA-GLORIA, BEATRIZ. Underground organs of Brazilian Asteraceae: testing the CLO-PLA database traits. FOLIA GEOBOTANICA, v. 52, n. 3-4, SI, p. 367-385, DEC 2017. (14/09401-0, 10/51454-3)

DE OLIVEIRA, ADRIANA DA S. S.; IMAMURA, PAULO M.; RUIZ, ANA L. T. G.; APPEZZATO-DA-GLORIA, BEATRIZ; DE OLIVEIRA, TUANE; GARCIA, VERA L.. Antiproliferative activity from Aldama arenaria (Baker) E. E. Schill. & Panero. Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, v. 20, n. 1, p. 51-60, JAN 2021. (10/51454-3)

DE SOUZA, MARCELO CLARO; HABERMANN, GUSTAVO; DO AMARAL, CARITA LIBERATO; ROSA, ANNYLORY LIMA; ONGARO PINHEIRO, MARCELO HENRIQUE; DA COSTA, FERNANDO BATISTA. Vochysia tucanorum Mart.: an aluminum-accumulating species evidencing calcifuge behavior. PLANT AND SOIL, v. 419, n. 1-2, p. 377-389, OCT 2017. (13/21293-6, 14/26866-7, 10/51454-3)

BOMBO, ALINE BERTOLOSI; FILARTIGA, ARINAWA LIZ; GARCIA, VERA LUCIA; APPEZZATO-DA-GLORIA, BEATRIZ. Secretory structures in Aldama species (Heliantheae-Asteraceae): morphology, histochemistry and composition of essential oils. FLORA, v. 228, p. 39-49, MAR 2017. (12/02476-0, 12/01586-6, 10/51454-3)

LUSA, MAKELI GARIBOTTI; PATRICE LOEUILLE, BENOIT FRANCIS; APPEZZATO-DA-GLORIA, BEATRIZ. First record of phytomelanin in aerial vegetative organs and its evolutionary implications in Lychnophorinae (Vernonieae: Asteraceae). PERSPECTIVES IN PLANT ECOLOGY EVOLUTION AND SYSTEMATICS, v. 33, p. 18-33, AUG 2018. (10/51454-3, 10/02085-5)

SANTOS DE OLIVEIRA, ADRIANA DA SILVA; CONRADO, GABRIELLY GALDINO; GRAZZIA, NATHALIA; MIGUEL, DANILO CICCONE; FRANCHI JUNIOR, GILBERTO CARLOS; GARCIA, VERA LUCIA. In Vitro Cytotoxic and Leishmanicidal Activity of Isolated and Semisynthetic ent -Pimaranes from Aldama arenaria. Planta Medica, v. 88, n. 13, p. 12-pg., 2022-02-10. (10/51454-3)

PADILLA-GONZALEZ, GUILLERMO F.; DIAZGRANADOS, MAURICIO; DA COSTA, FERNANDO B.. Biogeography shaped the metabolome of the genus Espeletia: a phytochemical perspective on an Andean adaptive radiation. SCIENTIFIC REPORTS, v. 7, AUG 18 2017. (14/17702-0, 14/26866-7, 10/51454-3)

LUSA, MAKELI G.; DA COSTA, FERNANDO B.; APPEZZATO-DA-GLORIA, BEATRIZ. Histolocalization of chemotaxonomic markers in Brazilian Vernonieae (Asteraceae). Botanical Journal of the Linnean Society, v. 182, n. 3, p. 581-593, NOV 2016. (10/51454-3, 10/02085-5)

LUSA, MAKELI G.; MARTUCCI, MARIA E. P.; LOEUILLE, BENOIT F. P.; GOBBO-NETO, LEONARDO; APPEZZATO-DA-GLORIA, BEATRIZ; DA COSTA, FERNANDO B.. Characterization and evolution of secondary metabolites in Brazilian Vernonieae (Asteraceae) assessed by LC-MS fingerprinting. Botanical Journal of the Linnean Society, v. 182, n. 3, p. 594-611, NOV 2016. (10/51454-3, 10/02085-5)

PADILLA-GONZALEZ, GUILLERMO FEDERICO; DOS SANTOS, FELIPE ANTUNES; DA COSTA, FERNANDO BATISTA. Sesquiterpene Lactones: More Than Protective Plant Compounds With High Toxicity. CRITICAL REVIEWS IN PLANT SCIENCES, v. 35, n. 1, p. 18-37, JAN 2 2016. (12/10249-3, 14/17702-0, 10/51454-3)

SAMPAIO, BRUNO LEITE; EDRADA-EBEL, RUANGELIE; DA COSTA, FERNANDO BATISTA. Effect of the environment on the secondary metabolic profile of Tithonia diversifolia: a model for environmental metabolomics of plants. SCIENTIFIC REPORTS, v. 6, JUL 7 2016. (11/13361-6, 10/51454-3)

CHAGAS-PAULA, DANIELA APARECIDA; OLIVEIRA, TIAGO BRANQUINHO; VASCONCELOS FALEIRO, DANNIELA PRSCYLLA; OLIVEIRA, REJANE BARBOSA; DA COSTA, FERNANDO BATISTA. Outstanding Anti-inflammatory Potential of Selected Asteraceae Species through the Potent Dual Inhibition of Cyclooxygenase-1 and 5-Lipoxygenase. Planta Medica, v. 81, n. 14, p. 1296-1307, SEP 2015. (10/10940-2, 10/51454-3)

OLIVEIRA, TIAGO B.; GOBBO-NETO, LEONARDO; SCHMIDT, THOMAS J.; DA COSTA, FERNANDO B.. Study of Chromatographic Retention of Natural Terpenoids by Chemoinformatic Tools. JOURNAL OF CHEMICAL INFORMATION AND MODELING, v. 55, n. 1, p. 26-38, JAN 2015. (11/17860-7, 13/14239-5, 10/51454-3, 08/05754-5)

BOMBO, ALINE BERTOLOSI; DE OLIVEIRA, TUANE SANTOS; SANTOS DE OLIVEIRA, ADRIANA DA SILVA; GARCIA REHDER, VERA LUCIA; GALVAO MAGENTA, MARA ANGELINA; APPEZZATO-DA-GLORIA, BEATRIZ. Anatomy and essential oils from aerial organs in three species of Aldama (Asteraceae-Heliantheae) that have a difficult delimitation. Australian Journal of Botany, v. 60, n. 7, p. 632-642, 2012. (10/01931-0, 10/51454-3)

FILARTIGA, ARINAWA LIZ; KLIMESOVA, JITKA; APPEZZATO-DA-GLORIA, BEATRIZ. Underground organs of Brazilian Asteraceae: testing the CLO-PLA database traits. FOLIA GEOBOTANICA, v. 52, n. 3-4, p. 19-pg., 2017-12-01. (14/09401-0, 10/51454-3)