Development of a vaccine against group A beta hemolytic Streptococcus

• Grant number: 00/14549-4
• Support Opportunities: Research Grants - Research Partnership for Technological Innovation - PITE
• Start date: April 01, 2002
• End date: December 13, 2006
• Field of knowledge: Biological Sciences - Immunology
• Principal Investigator: Luiza Guglielmi
• Grantee: Luiza Guglielmi
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Company: Laboratório Teuto Brasileiro Ltda
• City: São Paulo

Abstract

The principal aim of the present project was the development of a vaccine for the prevention of rheumatic fever and other infections caused by type A beta hemolytic streptococcus, in partnership with totally national private enterprise. Considering also the high socioeconomic costs of these pathologies, there is as a final goal the production of an effective subunit vaccine, that will offer protection against infections from the various serotypes of beta hemolytic streptococcus of the group. The vaccine should be, at the same time, safe and incapable of setting off chronic inflammatory or autoimmune reactions, such as observed in rheumatic fever. It will use as immunogene, sequences conserved from aminoacids of the C-terminal region of the M protein. Provided we keep our sights on the reliability and safety of the vaccine, its use may be guaranteed in the prevention of streptococcic infections with possibilities for applications also in developed countries. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

P.C. TEIXEIRA; L.K. IWAI; A.C.K. KURAMOTO; R. HONORATO; A. FIORELLI; N. STOLF; J. KALIL; E. CUNHA-NETO. Proteomic inventory of myocardial proteins from patients with chronic Chagas' cardiomyopathy. Brazilian Journal of Medical and Biological Research, v. 39, n. 12, p. 1549-1562, 2006-10-30. (01/00729-3, 00/14549-4)

GUILHERME‚ L.; FAÉ‚ KC; HIGA‚ F.; CHAVES‚ L.; OSHIRO‚ SE; DE BARROS‚ S.F.; PUSCHEL‚ C.; JULIANO‚ MA; TANAKA‚ AC; SPINA‚ G.; et al. Towards a vaccine against rheumatic fever. CLINICAL & DEVELOPMENTAL IMMUNOLOGY, v. 13, n. 2-4, p. 125-132, 2006. (00/14549-4)