From the bench to clinical trials: development of biomarkers as response predictors to therapy and target organs damage in systemic arterial hypertension

• Grant number: 07/58942-0
• Support Opportunities: Research Projects - Thematic Grants
• Start date: January 01, 2009
• End date: November 30, 2014
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Eduardo Moacyr Krieger
• Grantee: Eduardo Moacyr Krieger
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Principal investigators: Fernanda Marciano Consolim-Colombo ; José Eduardo Krieger ; Maria Claudia Costa Irigoyen
• Associated research grant(s): 14/07272-9 - Meeting of the european society of hypertension and international society of hypertension, AR.EXT
• Associated scholarship(s): 11/04111-6 - Role of baroreflex in the time course of autonomic and metabolic alterations of fructose-overload hypertension, BP.MS

Scientific publications

(16)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RODRIGUES, BRUNO; SANTANA, ALINE ALVES; SANTAMARINA, ALINE BOVETO; OYAMA, LILA MISSAE; CAPERUTO, ERICO CHAGAS; DE SOUZA, CLAUDIO TEODORO; BARBOZA, CATARINA DE ANDRADE; ROCHA, LEANDRO YANASE; FIGUEROA, DIEGO; MOSTARDA, CRISTIANO; et al. Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous System. Mediators of Inflammation, 2014. (07/58942-0, 13/14788-9)

DARIOLLI, RAFAEL; BASSANEZE, VINICIUS; NAKAMUTA, JULIANA SANAJOTTI; OMAE, SAMANTHA VIEIRA; CRISTINA, LUCIENE; CAMPOS, GASTALHO; KRIEGER, JOSE E.. Porcine Adipose Tissue-Derived Mesenchymal Stem Cells Retain Their Proliferative Characteristics, Senescence, Karyotype and Plasticity after Long-Term Cryopreservation. PLoS One, v. 8, n. 7, JUL 9 2013. (07/58942-0)

DA PUREZA, DEMILTO YAMAGUSHI; JORGE, LUCIANA; SANCHES, IRIS CALLADO; IRIGOYEN, MARIA-CLAUDIA; DE SOUZA, ROMEU RODRIGUES; DE ANGELIS, KATIA. Acute exercise adjustments of cardiovascular autonomic control in diabetic rats. MUSCLE & NERVE, v. 46, n. 1, p. 96-101, JUL 2012. (07/58942-0, 01/00009-0)

GIRAO-SILVA, THAIS; BASSANEZE, VINICIUS; GASTALHO CAMPOS, LUCIENE CRISTINA; BARAUNA, VALERIO GARRONE; OLIVEIRA DALLAN, LUIS ALBERTO; KRIEGER, JOSE EDUARDO; MIYAKAWA, AYUMI AUREA. Short-term mechanical stretch fails to differentiate human adipose-derived stem cells into cardiovascular cell phenotypes. BIOMEDICAL ENGINEERING ONLINE, v. 13, MAY 1 2014. (07/58942-0)

FERREIRA, NAOMI VIDAL; CUNHA, PAULO JANNUZZI; DA COSTA, DANIELLE IRIGOYEN; DOS SANTOS, FERNANDO; COSTA, FERNANDO OLIVEIRA; CONSOLIM-COLOMBO, FERNANDA; IRIGOYEN, MARIA CLAUDIA. Association between functional performance and executive cognitive functions in an elderly population including patients with low ankle-brachial index. CLINICAL INTERVENTIONS IN AGING, v. 10, p. 839-847, 2015. (07/58942-0, 10/51904-9)

BASSANEZE, VINICIUS; BARAUNA, VALERIO GARRONE; LAVINI-RAMOS, CAROLINA; KALIL, JORGE; SCHETTERT, ISOLMAR TADEU; MIYAKAWA, AYUMI AUREA; KRIEGER, JOSE EDUARDO. Shear Stress Induces Nitric Oxide-Mediated Vascular Endothelial Growth Factor Production in Human Adipose Tissue Mesenchymal Stem Cells. STEM CELLS AND DEVELOPMENT, v. 19, n. 3, p. 371-378, MAR 2010. (07/58942-0)

RODRIGUES, BRUNO; MOSTARDA, CRISTIANO T.; ROSA, KALEIZU T.; MARKOSKI, MELISSA; NARDI, NANCE B.; DE ANGELIS, KATIA; IRIGOYEN, MARIA CLAUDIA; KALIL, RENATO A. K.. VEGF(165) Gene Therapy Improves Left Ventricular Function and Exercise Capacity in Diabetic Rats after Myocardial Infarction: Impact on Mortality Rate. JOURNAL OF DIABETES & METABOLISM, v. 3, p. 8-pg., 2012-01-01. (07/58942-0)

JORGE, LUCIANA; DA PUREZA, DEMILTO Y.; DIAS, DANIELLE DA SILVA; CONTI, FILIPE FERNANDES; IRIGOYEN, MARIA-CLAUDIA; DE ANGELIS, KATIA. Dynamic Aerobic Exercise Induces Baroreflex Improvement in Diabetic Rats. Experimental Diabetes Research, 2012. (07/58942-0)

MOSTARDA, CRISTIANO; RODRIGUES, BRUNO; MEDEIROS, ALESSANDRA; MOREIRA, EDSON D.; MORAES-SILVA, IVANA C.; BRUM, PATRICIA C.; DE ANGELIS, KATIA; IRIGOYEN, MARIA-CLAUDIA. Baroreflex deficiency induces additional impairment of vagal tone, diastolic function and calcium handling proteins after myocardial infarction. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, v. 6, n. 3, p. 320-328, 2014. (12/20141-5, 07/58942-0)

MOSTARDA, CRISTIANO T.; RODRIGUES, BRUNO; DE MORAES, OSCAR ALBUQUERQUE; MORAES-SILVA, IVANA C.; OLINTO ARRUDA, PAULA BARROS; CARDOSO, RUYMAR; SCAPINI, KATIA BILHAR; DOS SANTOS, FERNANDO; DE ANGELIS, KATIA; IRIGOYEN, MARIA CLAUDIA. Low intensity resistance training improves systolic function and cardiovascular autonomic control in diabetic rats. JOURNAL OF DIABETES AND ITS COMPLICATIONS, v. 28, n. 3, p. 273-278, MAY-JUN 2014. (12/20141-5, 07/58942-0)

DE LA FUENTE, RAQUEL N.; RODRIGUES, BRUNO; MORAES-SILVA, IVANA C.; SOUZA, LEANDRO E.; SIRVENTE, RAQUEL; MOSTARDA, CRISTIANO; DE ANGELIS, KATIA; SOARES, PEDRO P.; LACCHINI, SILVIA; CONSOLIM-COLOMBO, FERNANDA; et al. Cholinergic stimulation with pyridostigmine improves autonomic function in infarcted rats. Clinical and experimental pharmacology & physiology, v. 40, n. 9, p. 610-616, SEP 2013. (07/58942-0)

RODRIGUES, BRUNO; JORGE, LUCIANA; MOSTARDA, CRISTIANO T.; ROSA, KALEIZU T.; MEDEIROS, ALESSANDRA; MALFITANO, CHRISTIANE; DE SOUZA, JR., ALCIONE L.; DA SILVA VIEGAS, KATIA APARECEDA; LACCHINI, SILVIA; CURI, RUI; et al. Aerobic Exercise Training Delays Cardiac Dysfunction and Improves Autonomic Control of Circulation in Diabetic Rats Undergoing Myocardial Infarction. JOURNAL OF CARDIAC FAILURE, v. 18, n. 9, p. 734-744, SEP 2012. (07/58942-0)

RODRIGUES, BRUNO; MOSTARDA, CRISTIANO T.; JORGE, LUCIANA; BARBOZA, CATARINA A.; GRANS, CAMILLA F.; DE ANGELIS, KATIA; IRIGOYEN, MARIA CLAUDIA. Impact of myocardial infarction on cardiac autonomic function in diabetic rats. JOURNAL OF DIABETES AND ITS COMPLICATIONS, v. 27, n. 1, p. 16-22, JAN-FEB 2013. (07/58942-0)

RODRIGUES, BRUNO; SANTANA, ALINE ALVES; SANTAMARINA, ALINE BOVETO; OYAMA, LILA MISSAE; CAPERUTO, ERICO CHAGAS; DE SOUZA, CLAUDIO TEODORO; BARBOZA, CATARINA DE ANDRADE; ROCHA, LEANDRO YANASE; FIGUEROA, DIEGO; MOSTARDA, CRISTIANO; et al. Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous System. Mediators of Inflammation, v. 2014, p. 13-pg., 2014-01-01. (07/58942-0, 13/14788-9)

JORGE, LUCIANA; DA PUREZA, DEMILTO Y.; DIAS, DANIELLE DA SILVA; CONTI, FILIPE FERNANDES; IRIGOYEN, MARIA-CLAUDIA; DE ANGELIS, KATIA. Dynamic Aerobic Exercise Induces Baroreflex Improvement in Diabetic Rats. Experimental Diabetes Research, v. N/A, p. 5-pg., 2012-01-01. (07/58942-0)

CASTRO, E. F. S.; MOSTARDA, C. T.; RODRIGUES, B.; MORAES-SILVA, I. C.; FERIANI, D. J.; DE ANGELIS, K.; IRIGOYEN, M. C.. Exercise training prevents increased intraocular pressure and sympathetic vascular modulation in an experimental model of metabolic syndrome. Brazilian Journal of Medical and Biological Research, v. 48, n. 4, p. 332-338, APR 2015. (12/20141-5, 07/58942-0)