Combination of cisplatin and laser thermal therapy for head and neck cancer

• Grant number: 08/54714-6
• Support Opportunities: Research Projects - Thematic Grants
• Start date: November 01, 2008
• End date: October 31, 2015
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Marcos Bandiera Paiva
• Grantee: Marcos Bandiera Paiva
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Laser thermal ablation of malignant tumors using the Nd:YAG laser continues to expand into a multi-discipline specialty known as “laser induced thermal-therapy (LITT)”. This minimally invasive treatment has proved to be very useful, particularly for palliation of advanced obstructing cancers of the gastrointestinal and bronchial tracts by endoscopic recanalization. During LITT high photo-thermal laser energy levels are delivered to the area of maximum obstruction inducing irreversible coagulative changes while lower levels to the tumor margin. Reversible hyperthermic damage in the tumor margins frequently leads to tumor recurrence requiring additional laser application for tumor eradication. In an attempt to improve tumor response after LITT for recurrent head and neck cancer, this investigator has been exploring ways to couple chemotherapy with laser ablation as an adjunct strategy to eliminate regrowth in the periphery of LITT treatment sites. The purpose of this research project is to improve local control of disease in patients with recurrent head and neck cancer, by regional injections of chemotherapy followed by laser therapy. The primary objective of this phase I study is to determine the MTD (maximal toxicity dose) and toxicity of escalating doses of intratumor injections of CDDP combined with a fixed dose of laser thermal therapy using the Nd:YAG laser for patients with refractory head and neck cancer. Secondary objectives is to analyze the impact of combined CDDP-LITT on the quality of life. The quintessencial goal of this minimal invasive treatment is to treat cancer by high doses of intratumor chemotherapy and local hyperthermia. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PAIVA, MARCOS B.; JOO, JAYNE; ABRAHAO, MARCIO; RIBEIRO, JOAO CARLOS; CERVANTES, ONIVALDO; SERCARZ, JOEL A.. Update on Laser Photochemotherapy: An Alternative for Cancer Treatment. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, v. 11, n. 8, p. 772-779, OCT 2011. (08/54714-6)

SERCARZ, JOEL A.; BUBLIK, MICHAEL; JOO, JAYNE; PAIVA, PAULO B.; ARECO, KELSY N.; BRANDALISE, MARIA HELENA; LOH, CHRISTOPHER; MASTERMAN-SMITH, MICHAEL; PAIVA, MARCOS B.. Outcomes of laser thermal therapy for recurrent head and neck cancer. OTOLARYNGOLOGY-HEAD AND NECK SURGERY, v. 142, n. 3, p. 344-350, MAR 2010. (08/54714-6)

DE BRITO, RENAN VIEIRA; MANCINI, MARILIA WELLICHAN; PALUMBO, MARCEL DAS NEVES; OLIVEIRA DE MORAES, LUIS HENRIQUE; RODRIGUES, GERSON JHONATAN; CERVANTES, ONIVALDO; SERCARZ, JOEL AVRAM; PAIVA, MARCOS BANDIERA. The Rationale for "Laser-Induced Thermal Therapy (LITT) and Intratumoral Cisplatin" Approach for Cancer Treatment. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 11, p. 33-pg., 2022-06-01. (08/54714-6)