The agreement with the Innovation Fund Denmank (former DCSR) aims to implement scientific and technological cooperation between researchers of Denmark and the State of São Paulo, Brazil, through the financing of joint research projects.
The overarching aim of this proposal is to delineate the common molecular networks in adipose tissue involved in the lifespan and health promoting effects of dietary restriction and its mimetics such as dietary Methionine Restriction (MR) and dietary supplementation with Nicotinamide Riboside (NR) - a dairy constituent that maintains NAD metabolism. To achieve that, we designed a pipeline…
According to a recent United Nations estimate, the number of people 65 and older is expected to triple by mid-century, from 531 million in 2010 to 1.5 billion in 2050. Malnutrition, as a consequence of age-induced malabsorption of essential nutrients, is associated with risk of falls and fractures, weak immune system, vision problems and increasing risk of infections. Milk and dairy produ…
One of the challenges facing our society is how food and feed can be produced sustainably in a world of 9 billion people. New knowledge, technology and approaches are needed in to use our agricultural resources more efficiently. The solutions will not provide quantum leaps, but rather incremental changes introducing new technologies for processing biomass to food or feed products. This p…
(Only some records are available in English at this moment)
The present proposal is part of the Novel Aging thematic grant (Technologies and solutions to manufacture novel dairy products for healthy aging/FAPESP 2017/01189-0). This project has the goal of developing a microfluidic device able to simulate the human digestion (oral and gastric phase) of unmodified milk proteins, evaluating the digestion efficiency by nESI-MS and the allergic respons…
Dietary restriction extends lifespan across species from yeast to primates. It is well established that dietary restricted mice live longer than ad libitum fed mice and are protected from metabolic diseases like diabetes and obesity, as well as cancer, cardiovascular disease and other age-related complications. In mammals, part of the beneficial effect of dietary restriction is thought to…
Dietary restriction extends lifespan across species from yeast to primates. The study of the nematode C. elegans - where multiple protocols of dietary restriction has been shown to prolong lifespan in overlapping yet not necessarily identical manners has led to the identification of multiple evolutionarily conserved pathways associated with aging and the mechanisms of dietary restriction.…
(Only some records are available in English at this moment)
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