| Texto completo | |
| Autor(es): Mostrar menos - |
Chao, Monica C. M.
;
Garcia, Cristiane S. N. B.
;
de Oliveira, Mariana B. G.
;
Santos, Raquel S.
;
Lucas, Isabela H.
;
Silva, Pedro L.
;
Vieira-Abreu, Adriana
[1]
;
de Castro-Faria-Neto, Hugo C.
[1]
;
Parra-Cuentas, Edwin R.
[2]
;
Capelozzi, Vera L.
[2]
;
Pelosi, Paolo
[3]
;
Rocco, Patricia R. M.
[4]
Número total de Autores: 12
|
| Afiliação do(s) autor(es): | [1] Fiocruz MS, Oswaldo Cruz Inst, Lab Immunopharmacol, BR-21045900 Rio De Janeiro - Brazil
[2] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo - Brazil
[3] Univ Insubria, Dept Ambient Hlth & Safety, Varese - Italy
[4] Univ Fed Rio de Janeiro, Lab Pulm Invest, Carlos Chagas Filho Biophys Inst, Ctr Ciencias Saude, Ilha Fundao, BR-21941902 Rio De Janeiro - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Respiratory Physiology & Neurobiology; v. 173, n. 2, p. 179-188, SEP 30 2010. |
| Citações Web of Science: | 16 |
| Resumo | |
We tested the hypothesis that at the early phase of acute lung injury (ALI) the degree of endothelium injury may predict lung parenchyma remodelling For this purpose, two models of extrapulmonary ALI induced by Escherichia col: lipopolysaccharide (ALI-LPS) or cecal ligation and puncture (ALI-CLP) were developed in mice At day 1, these models had similar degrees of lung mechanical compromise, epithelial damage, and intraperitoneal inflammation, but endothelial lesion was greater in ALI-CLP A time course analysis revealed, at day 7 ALI-CLP had higher degrees of epithelial lesion, denudation of basement membrane, endothelial damage, elastic and collagen fibre content, neutrophils in bronchoalveolar lavage fluid (BALF), peritoneal fluid and blood, levels of interleukin-6, KC (murine analogue of IL-8), and transforming growth factor-beta in BALF Conversely, the number of lung apoptotic cells was similar in both groups In conclusion, the intensity of fibroelastogenesis was affected by endothelium injury in addition to the maintenance of epithelial damage and intraperitoneal inflammation. (C) 2010 Elsevier B V All rights reserved (AU) | |