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Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium

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Autor(es):
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Aldape, Kenneth [1] ; Amin, Samirkumar B. [2] ; Ashley, David M. [3] ; Barnholtz-Sloan, Jill S. [4] ; Bates, Amanda J. [5] ; Beroukhim, Rameen [6, 7] ; Bock, Christoph [8] ; Brat, Daniel J. [9] ; Claus, Elizabeth B. [10, 11] ; Costello, Joseph F. [12] ; de Groot, John F. [13] ; Finocchiaro, Gaetano [14] ; French, Pim J. [15] ; Gan, Hui K. [16] ; Griffith, Brent [17] ; Herold-Mende, Christel C. [18] ; Horbinski, Craig [9] ; Iavarone, Antonio [19] ; Kalkanis, Steven N. [20] ; Karabatsou, Konstantina [21] ; Kim, Hoon [2] ; Kouwenhoven, Mathilde C. M. [22] ; McDonald, Kerrie L. [23] ; Miletic, Hrvoje [24] ; Nam, Do-Hyun [25] ; Ng, Ho Keung [26] ; Niclou, Simone P. [27] ; Noushmehr, Houtan [20] ; Ormond, D. Ryan [28] ; Poisson, Laila M. [20] ; Reifenberger, Guido [29] ; Roncaroli, Federico [30] ; Sa, Jason K. [31] ; Smitt, Peter A. E. Sillevis [15] ; Smits, Marion [32] ; Souza, Camila F. [20] ; Tabatabai, Ghazaleh [33, 34] ; Van Meir, Erwin G. [35, 36, 37, 38] ; Verhaak, Roel G. W. [39] ; Watts, Colin [40] ; Wesseling, Pieter [41, 42, 43] ; Woehrer, Adelheid [44] ; Yung, W. K. Alfred [45] ; Jungk, Christine [46] ; Hau, Ann-Christin [27] ; van Dyck, Eric [27] ; Westerman, Bait A. [47] ; Yin, Julia [48] ; Abiola, Olajide [39] ; Zeps, Nikolaj [49, 50] ; Grimmond, Sean [49, 51, 52] ; Buckland, Michael [53, 54] ; Khasraw, Mustafa [55] ; Sulman, Erik P. [56] ; Muscat, Andrea M. [57] ; Stead, Lucy [58] ; Consortium, GLASS
Número total de Autores: 57
Afiliação do(s) autor(es):
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[1] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON - Canada
[2] Jackson Lab Genom Med, Ten Discovery Dr, Farmington, CT - USA
[3] Duke Univ, Med Ctr, Preston Robert Tisch Brain Tumor Ctr Duke, Durham, NC - USA
[4] Case Western Reserve Univ, Sch Med, Case Comprehens Canc Ctr, Cleveland, OH - USA
[5] Natl Brain Tumor Soc, Newton, MA - USA
[6] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 - USA
[7] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 - USA
[8] Austrian Acad Sci, CeMM Res Ctr Mol Med, Vienna - Austria
[9] Northwestern Univ, Dept Pathol, Feinberg Sch Med, Chicago, IL 60611 - USA
[10] Yale Sch Publ Hlth, New Haven, CT - USA
[11] Brigham & Womens Hosp, Dept Neurosurg, 75 Francis St, Boston, MA 02115 - USA
[12] Univ Calif San Francisco, San Francisco, CA 94143 - USA
[13] Univ Texas MD & Anderson Canc Ctr, Houston, TX - USA
[14] Fdn IRCCS Ist Neurol Besta, Milan - Italy
[15] Erasmus MC, Dept Neurol, Rotterdam - Netherlands
[16] Austin Hlth, Olivia Newton John Canc Res Inst, Melbourne, Vic - Australia
[17] Henry Ford Hlth Syst, Dept Radiol, Detroit, MI - USA
[18] Heidelberg Univ, Dept Neurosurg, Div Expt Neurosurg, Heidelberg - Germany
[19] Columbia Univ, Med Ctr, Dept Neurol, Dept Pathol, Inst Canc Genet, New York, NY - USA
[20] Henry Ford Hlth Syst, Dept Neurosurg, Detroit, MI - USA
[21] Salford Royal Hosp, Stott Lane, Manchester - England
[22] Vrije Univ Amsterdam Med Ctr, Brain Tumor Ctr, Dept Neurol, Amsterdam - Netherlands
[23] Univ NSW, Cure Brain Canc Biomarkers & Translat Res Grp, Prince Wales Clin Sch, Sydney, NSW - Australia
[24] Haukeland Hosp, Dept Pathol, Bergen - Norway
[25] Sungkyunkwan Univ, Dept Neurosurg, Samsung Med Ctr, Sch Med, Seoul - South Korea
[26] Chinese Univ Hong Kong, Dept Pathol, Prince Wales Hosp, Shatin, Hong Kong - Peoples R China
[27] Luxembourg Inst Hlth, NorLux Neurooncol Lab, Luxembourg - Luxembourg
[28] Univ Colorado, Sch Med, Dept Neurosurg, Aurora, CO - USA
[29] Heinrich Heine Univ Duesseldorf, Med Fac, Dept Neuropathol, Dusseldorf - Germany
[30] Univ Manchester, Fac Biol Med & Hlth, Div Neurosci & Expt Psychol, Manchester, Lancs - England
[31] Samsung Med Ctr, Res Inst Future Med, Seoul - South Korea
[32] Erasmus MC, Dept Radiol & Nucl Med, Rotterdam - Netherlands
[33] Univ Hosp, Dept Neurol, Interdisciplinary Div Neurooncol, Tubingen - Germany
[34] Univ Hosp, Dept Neurosurg, Interdisciplinary Div Neurooncol, Tubingen - Germany
[35] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 - USA
[36] Emory Univ, Dept Neurosurg, Sch Med, Atlanta, GA 30322 - USA
[37] Emory Univ, Dept Hematol, Sch Med, Atlanta, GA 30322 - USA
[38] Emory Univ, Dept Med Oncol, Sch Med, Atlanta, GA 30322 - USA
[39] Jackson Lab Genom Med, Ten Discovery Dr, Farmington, CT 06032 - USA
[40] Univ Cambridge, Div Neurosurg, Dept Clin Neurosci, Cambridge - England
[41] Vrije Univ Amsterdam Med Ctr, Brain Tumor Ctr Amsterdam, Dept Pathol, Amsterdam - Netherlands
[42] Princess Maxima Ctr Pediat Oncol, Utrecht - Netherlands
[43] Univ Med Ctr Utrecht, Utrecht - Netherlands
[44] Med Univ Vienna, Inst Neurol, Vienna - Austria
[45] UT MD Anderson Canc Ctr, Houston, TX - USA
[46] Heidelberg Univ, Dept Neurosurg, Heidelberg - Germany
[47] Vrije Univ Amsterdam Med Ctr, Brain Tumor Ctr Amsterdam, Canc Ctr Amsterdam, Amsterdam - Netherlands
[48] Univ New South Wales, Prince Wales Clin Sch, Cure Brain Canc Biomarkers & Translat Res Grp, Sydney, NSW - Australia
[49] Monash Univ, Melbourne, Vic - Australia
[50] Epworth Hlth, Melbourne, Vic - Australia
[51] Univ Melbourne, Melbourne, Vic - Australia
[52] Victorian Comprehens Canc Ctr, Melbourne, Vic - Australia
[53] Univ Sydney, Sydney, NSW - Australia
[54] Royal Prince Alfred Hosp, Sydney, NSW - Australia
[55] Univ Sydney, Cooperat Trials Grp Neurooncol COGNO, NHMRC Clin Trials Ctr, Sydney, NSW - Australia
[56] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 - USA
[57] Deakin Univ, Geelong, Vic - Australia
[58] St James Univ Hosp, Leeds, W Yorkshire - England
Número total de Afiliações: 58
Tipo de documento: Artigo Científico
Fonte: NEURO-ONCOLOGY; v. 20, n. 7, p. 873-884, JUL 2018.
Citações Web of Science: 0
Resumo

Adult diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas and similar projects have provided a comprehensive understanding of the somatic alterations and molecular subtypes of glioma at diagnosis. However, gliomas undergo significant cellular and molecular evolution during disease progression. We review the current knowledge on the genomic and epigenetic abnormalities in primary tumors and after disease recurrence, highlight the gaps in the literature, and elaborate on the need for a new multi-institutional effort to bridge these knowledge gaps and how the Glioma Longitudinal Analysis Consortium (GLASS) aims to systemically catalog the longitudinal changes in gliomas. The GLASS initiative will provide essential insights into the evolution of glioma toward a lethal phenotype, with the potential to reveal targetable vulnerabilities and, ultimately, improved outcomes for a patient population in need. (AU)

Processo FAPESP: 15/07925-5 - Softwares de código aberto contendo ferramentas estatísticas para análise e integração de conjuntos de dados epigenômicos produzidos em alta escala, a fim de decifrar e entender redes reguladoras de câncer
Beneficiário:Houtan Noushmehr
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
Processo FAPESP: 14/08321-3 - Identificação e caracterização de elementos genômicos funcionais associados com a progressão de gliomas de baixo grau a gliomas de alto grau: estudo integrado do genoma e epigenoma
Beneficiário:Camila Ferreira de Souza
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 16/15485-8 - Biomarcadores clínicos em tumores do sistema nervoso central
Beneficiário:Camila Ferreira de Souza
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado