Genome-wide association between single nucleotide ... - BV FAPESP
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Genome-wide association between single nucleotide polymorphisms with beef fatty acid profile in Nellore cattle using the single step procedure

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Lemos, Marcos V. A. [1] ; Justino Chiaia, Hermenegildo Lucas [1] ; Berton, Mariana Piatto [1] ; Feitosa, Fabieli L. B. [1] ; Aboujaoud, Carolyn [1] ; Camargo, Gregorio M. F. [1] ; Pereira, Angelica S. C. [2] ; Albuquerque, Lucia G. [1] ; Ferrinho, Adrielle M. [2] ; Mueller, Lenise F. [2] ; Mazalli, Monica R. [2] ; Furlan, Joyce J. M. [2] ; Carvalheiro, Roberto [1] ; Gordo, Daniel M. [1] ; Tonussi, Rafael [1] ; Espigolan, Rafael [1] ; de Oliveira Silva, Rafael Medeiros [1] ; de Oliveira, Henrique Nunes [1] ; Duckett, Susan [3] ; Aguilar, Ignacio [4] ; Baldi, Fernando [1]
Número total de Autores: 21
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista, Fac Ciencias Agr & Vet, Dept Zootecnia, Via Acesso Prof Paulo Donato Castellane S-No, BR-14884900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Nutr & Prod Anim, Ave Duque de Caxias Norte 225, BR-13635900 Sao Paulo - Brazil
[3] Clemson Univ, Dept Anim & Vet Sci, Clemson, SC - USA
[4] Natl Inst Agr Res Uruguayy, Dept Anim Breeding Montevideo, Montevideo - Uruguay
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: BMC Genomics; v. 17, MAR 9 2016.
Citações Web of Science: 11
Resumo

Background: Saturated fatty acids can be detrimental to human health and have received considerable attention in recent years. Several studies using taurine breeds showed the existence of genetic variability and thus the possibility of genetic improvement of the fatty acid profile in beef. This study identified the regions of the genome associated with saturated, mono-and polyunsaturated fatty acids, and n-6 to n-3 ratios in the Longissimus thoracis of Nellore finished in feedlot, using the single-step method. Results: The results showed that 115 windows explain more than 1 % of the additive genetic variance for the 22 studied fatty acids. Thirty-one genomic regions that explain more than 1 % of the additive genetic variance were observed for total saturated fatty acids, C12:0, C14:0, C16:0 and C18:0. Nineteen genomic regions, distributed in sixteen different chromosomes accounted for more than 1 % of the additive genetic variance for the monounsaturated fatty acids, such as the sum of monounsaturated fatty acids, C14:1 cis-9, C18:1 trans-11, C18:1 cis-9, and C18:1 trans-9. Forty genomic regions explained more than 1 % of the additive variance for the polyunsaturated fatty acids group, which are related to the total polyunsaturated fatty acids, C20:4 n-6, C18:2 cis-9 cis12 n-6, C18:3 n-3, C18:3 n-6, C22:6 n-3 and C20:3 n-6 cis-8 cis-11 cis-14. Twenty-one genomic regions accounted for more than 1 % of the genetic variance for the group of omega-3, omega-6 and the n-6:n-3 ratio. Conclusions: The identification of such regions and the respective candidate genes, such as ELOVL5, ESSRG, PCYT1A and genes of the ABC group (ABC5, ABC6 and ABC10), should contribute to form a genetic basis of the fatty acid profile of Nellore (Bos indicus) beef, contributing to better selection of the traits associated with improving human health. (AU)

Processo FAPESP: 11/21241-0 - Estudo da variabilidade genética do perfil de ácidos graxos da carne de bovinos da raça Nelore terminados em confinamento
Beneficiário:Fernando Sebastián Baldi Rey
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
Processo FAPESP: 09/16118-5 - Ferramentas genômicas no melhoramento genético de características de importância econômica direta em bovinos da raça Nelore
Beneficiário:Lucia Galvão de Albuquerque
Linha de fomento: Auxílio à Pesquisa - Temático