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Cannabidiol regulation of fear memory processing and associated brain function
| Pesquisador responsável: | Francisco Silveira Guimaraes |
| Beneficiário: | Francisco Silveira Guimaraes |
| Instituição: | Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto, SP, Brasil |
| Pesquisador responsável no exterior: | Carl William Stevenson |
| Instituição no exterior: | University of Nottingham, Sutton Bonington, Reino Unido |
| Pesquisador responsável no exterior: | Jonathan Loon Choon Lee |
| Instituição no exterior: | University of Birmingham, Reino Unido |
| Área do conhecimento: | Ciências Biológicas - Farmacologia - Neuropsicofarmacologia |
| Linha de fomento: | Auxílio à Pesquisa - Regular |
| Processo: | 12/50896-8 |
| Vigência: | 01 de fevereiro de 2013 - 31 de janeiro de 2015 |
| Convênio/Acordo de cooperação com a FAPESP: | University of Birmingham ; University of Nottingham |
| Assunto(s): | Transtornos de ansiedadeMemória (psicologia)MedoCórtex pré-frontalCanabidiol |
Resumo
Anxiety disorders such as phobias and post-traumatic stress are common and often debilitating diseases linked to abnormally persistent memories of fearful events. Although psychological and drug therapies are available, these treatments show limited effectiveness and can cause adverse side effects, highlighting the urgent need for better therapies to treat these disorders. Cannabidiol, the main non-psychotropic phytocannabinoid present in the Cannabis sativa plant, is a drug that has shown great promise for treating anxiety disorders. We have shown that cannabidiol reduces fear in various animal models of anxiety and have recently extended these findings to show that it also reduces fear memory expression. Interestingly, cannabidiol has also been shown to enhance fear memory extinction, the process by which psychological therapy can reduce fear memory persistence. However, the pharmacological mechanisms and brain sites involved in mediating these effects remain unclear or unknown. In this multi-disciplinary project we will combine behavioral, pharmacological, electrophysiological and molecular biology techniques to determine the neurochemical and neural circuit mechanisms underlying the effects of cannabidiol on fear memory processing. Specifically, we will examine the roles of endocannabinoid transmission and prefrontal cortex-hippocampus circuit function in mediating the effects of cannabidiol on the expression and extinction of contextual fear memory in rats. Understanding the basic mechanisms underlying cannabidiol's effects on behaviour and brain function has important translational implications for its potential use in treating anxiety. (AU)
Anxiety disorders such as phobias and post-traumatic stress are common and often debilitating diseases linked to abnormally persistent memories of fearful events. Although psychological and drug therapies are available, these treatments show limited effectiveness and can cause adverse side effects, highlighting the urgent need for better therapies to treat these disorders. Cannabidiol, the main non-psychotropic phytocannabinoid present in the Cannabis sativa plant, is a drug that has shown great promise for treating anxiety disorders. We have shown that cannabidiol reduces fear in various animal models of anxiety and have recently extended these findings to show that it also reduces fear memory expression. Interestingly, cannabidiol has also been shown to enhance fear memory extinction, the process by which psychological therapy can reduce fear memory persistence. However, the pharmacological mechanisms and brain sites involved in mediating these effects remain unclear or unknown. In this multi-disciplinary project we will combine behavioral, pharmacological, electrophysiological and molecular biology techniques to determine the neurochemical and neural circuit mechanisms underlying the effects of cannabidiol on fear memory processing. Specifically, we will examine the roles of endocannabinoid transmission and prefrontal cortex-hippocampus circuit function in mediating the effects of cannabidiol on the expression and extinction of contextual fear memory in rats. Understanding the basic mechanisms underlying cannabidiol's effects on behaviour and brain function has important translational implications for its potential use in treating anxiety. (AU)
Publicações científicas
(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)
FOGACA, M. V.;
REIS, F. M. C. V.;
CAMPOS, A. C.;
GUIMARAES, F. S.
Effects of intra-prelimbic prefrontal cortex injection of cannabidiol on anxiety-like behavior: Involvement of 5HT(1A) receptors and previous stressful experience.
European Neuropsychopharmacology,
v. 24,
n. 3,
p. 410-419,
MAR 2014.
Citações Web of Science: 0.
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cdi@fapesp.br.
CDi/FAPESP - Centro de Documentação e Informação da Fundação de Amparo à Pesquisa do Estado de São Paulo
R. Pio XI, 1500 - Alto da Lapa - CEP 05468-901 - São Paulo/SP - Brasil
cdi@fapesp.br - Converse com a FAPESP
R. Pio XI, 1500 - Alto da Lapa - CEP 05468-901 - São Paulo/SP - Brasil
cdi@fapesp.br - Converse com a FAPESP