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Evaluation of the synergistic effects of nitric oxide and singlet oxygen produced by ruthenium-phthalocyanine complexes in lung tumors: photochemical and photophysical studies, in vitro and in vivo cytotoxicity

Processo: 12/50588-1
Linha de fomento:Auxílio à Pesquisa - Regular
Vigência: 01 de outubro de 2012 - 30 de setembro de 2014
Área do conhecimento:Ciências da Saúde - Farmácia
Convênio/Acordo: King's College London
Pesquisador responsável:Roberto Santana da Silva
Beneficiário:Roberto Santana da Silva
Pesq. responsável no exterior: Lea Ann Dailey
Instituição no exterior: King's College London, Inglaterra
Instituição-sede: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto, SP, Brasil
Vinculado ao auxílio:10/11937-5 - Compostos nitrosilos de rutênio-quantum dot como agente produtor de óxido nítrico e oxigênio singlete: aspectos fotoquímicos, fotofísicos e citotóxicos, AP.R
Assunto(s):Terapia fotodinâmica  Óxido nítrico  Nitrosil  Rutênio 

Resumo

The research developed in our laboratory (da Silva; USP) involves chemical, photochemical, kinetic, pharmacological and cytotoxic studies of NO donor compounds. We have published several articles involving this subject and among these the first publication reporting the photoinduced electron transfer process for NO release was described in a work by our group (SAUAIA et al, 2003 and 2005). The pursuit of these species is of great interest since there is the possibility of creating a new clinical therapy against cancer, based on light irradiation, the technique known as photodynamic therapy (PDT). Although more studies have been published since our first report, as far as we are aware there are no studies correlating the photochemical, photophysical and cytotoxic activity of compounds that produce NO and singlet oxygen at the same time. The ongoing project concerns the possibility of releasing ROS and ERONs in a controlled manner by photoinduction using ruthenium nitrosyl compounds. It is expected that using this system potentiates the antitumor activity in neoplastic systems. The luminescence characteristic of phthalocyanine compounds will also allow cell imaging, which will be exploited to provide us with evidence on the effectiveness of therapy. (AU)