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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

An overview of amines as nutritional supplements to counteract cancer cachexia

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Author(s):
de Campos-Ferraz, Patricia Lopes [1, 2] ; Andrade, Isabel [1, 2] ; das Neves, Willian [1] ; Hangai, Isabela [1] ; Rodrigues Alves, Christiano Robles [1] ; Lancha, Jr., Antonio Herbert [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo - Brazil
[2] Univ Estadual Campinas, Fac Sci Appl, BR-13484350 Limeira, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE; v. 5, n. 2, p. 105-110, JUN 2014.
Web of Science Citations: 14
Abstract

Cancer cachexia is a complex multifactorial syndrome characterized by loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment. Recently, some amino acids and other amine dietary supplements have been highlighted in medical field due to positive effects upon diseases evolving skeletal muscle atrophy. Therefore, the aim of this brief review is to discuss the putative application of amines as dietary supplements to counteract skeletal muscle wasting on cancer cachexia. Specifically, we focus in two nutritional supplements: (1) branched-chain amino acids (BCAAs) and (2) creatine. Both BCAAs and creatine may attenuate proteolysis and enhance proteins synthesis in skeletal muscle. Although more experimental studies and clinical trials are still necessary to elucidate this therapeutic application, several evidences have demonstrated that amines supplementation is a promising coadjuvant treatment to cancer cachexia. (AU)

FAPESP's process: 12/07319-0 - Effect of an alimentary supplement used in order to improve bone mineral density
Grantee:Antonio Herbert Lancha Junior
Support type: Scholarships abroad - Research
FAPESP's process: 13/04744-4 - Effects of strength training on skeletal muscle in mice with cachexia induced cancer
Grantee:Willian das Neves Silva
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/02682-9 - "creatine supplementation in walker 256 tumor-bearing rats"
Grantee:Patricia Lopes de Campos Ferraz
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/25240-1 - Effects of high-intensity interval training on skeletal muscle of Walker 256 tumor-bearing rats
Grantee:Christiano Robles Rodrigues Alves
Support type: Scholarships abroad - Research Internship - Master's degree