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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

F-18-Fluoride PET/CT and Tc-99m-MDP SPECT/CT can detect bone cancer at early stage in rodents

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Author(s):
Alves, Christiano R. R. [1, 2] ; Faria, Daniele de P. [3] ; Carneiro, Camila de G. [3] ; Garcez, Alexandre T. [3] ; Gutierrez, Vanessa P. [4] ; das Neves, Willian [1] ; de Almeida, Ney R. [1] ; Cury, Yara [4] ; Chammas, Roger [3] ; Brum, Patricia C. [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo - Brazil
[2] Harvard Med Sch, Joslin Diabet Ctr, Boston, MA - USA
[3] Univ Sao Paulo, Dept Radiol & Oncol, Fac Med, Sao Paulo - Brazil
[4] Butantan Inst, Lab Pain & Signaling, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Life Sciences; v. 206, p. 29-34, AUG 1 2018.
Web of Science Citations: 0
Abstract

Noninvasive imaging using positron emission tomography/computed tomography (PET/CT) and single photon emission computed tomography/computed tomography (SPECT/CT) are considered revolutionized approaches to detect bone cancer. Both PET/CT and SPECT/CT technologies have advanced to permit miniaturization, which has provided the advantage of including animals as their own controls in longitudinal studies. The present study was designed to evaluate the potential of PET/CT and SPECT/CT as research tools to detect bone cancer in rats. We used a rat model of bone cancer induced by injecting Walker 256 tumor cells into the femoral cavity. Computed tomography demonstrated that rats presented a solid tumor at 15 days post injection (dpi). However, CT was not an effective method for identifying tumors at an earlier time point (8 dpi), when mechanical hyperalgesia (the most common symptom during bone cancer progression) had already initiated. At this early stage, PET/CT and SPECT/CT analysis detected higher uptake in the injected femur of the tracers F-18-Fluoride and Tc-99m-Methyl diphosphonate (Tc-99m-MDP), respectively. These findings demonstrated for the first time that both F-18-Fluoride PET/CT and Tc-99m-MDP SPECT/CT can detect cancer at early stages in rats and advocates for the PET/SPECT/CT as research tools to evaluate bone cancer in further longitudinal studies involving small animals. (AU)

FAPESP's process: 15/22814-5 - Cancer and heart: new paradigms of diagnosis and treatment
Grantee:Carlos Eduardo Negrão
Support type: Research Projects - Thematic Grants
FAPESP's process: 12/25240-1 - Effects of high-intensity interval training on skeletal muscle of Walker 256 tumor-bearing rats
Grantee:Christiano Robles Rodrigues Alves
Support type: Scholarships abroad - Research Internship - Master's degree
FAPESP's process: 16/01478-0 - Molecular mechanisms underlying cancer cachexia: exploring the role of COPS2
Grantee:Christiano Robles Rodrigues Alves
Support type: Scholarships abroad - Research Internship - Doctorate (Direct)
FAPESP's process: 12/02528-0 - Effects of high-intensity physical training on skeletal muscle of walker 256 tumor-bearing rats
Grantee:Christiano Robles Rodrigues Alves
Support type: Scholarships in Brazil - Master
FAPESP's process: 14/03016-8 - Cancer cachexia: effects of aerobic physical training on skeletal muscle in animal model
Grantee:Christiano Robles Rodrigues Alves
Support type: Scholarships in Brazil - Doctorate (Direct)