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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

On the synthesis of quinone-based BODIPY hybrids: New insights on antitumor activity and mechanism of action in cancer cells

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Author(s):
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Gontijo, Talita B. ; de Freitas, Rossimiriam P. ; Emery, Flavio S. ; Pedrosa, Leandro F. ; Vieira Neto, Jose B. ; Cavalcanti, Bruno C. ; Pessoa, Claudia ; King, Aaron ; de Moliner, Fabio ; Vendrell, Marc ; da Silva Junior, Eufrnio N.
Total Authors: 11
Document type: Journal article
Source: Bioorganic & Medicinal Chemistry Letters; v. 27, n. 18, p. 4446-4456, SEP 15 2017.
Web of Science Citations: 0
Abstract

Fluorescent quinone-based BODIPY hybrids were synthesised and characterised by NMR analysis and mass spectrometry. We measured their cytotoxic activity against cancer and normal cell lines, performed mechanistic studies by lipid peroxidation and determination of reduced (GSH) and oxidized (GSSG) glutathione, and imaged their subcellular localisation by confocal microscopy. Cell imaging experiments indicated that nor-beta-lapachone-based BODIPY derivatives might preferentially localise in the lysosomes of cancer cells. These results assert the potential of hybrid quinone-BODIPY derivatives as promising prototypes in the search of new potent lapachone antitumor drugs. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 14/22451-7 - Sustained drug delivery systems targeting the epithelial tissue
Grantee:Renata Fonseca Vianna Lopez
Support type: Research Projects - Thematic Grants