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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hydrogel increases localized transport regions and skin permeability during low frequency ultrasound treatment

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Author(s):
Pereira, Tatiana Aparecida ; Ramos, Danielle Nishida ; Lopez, Renata F. V.
Total Authors: 3
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 7, MAR 13 2017.
Web of Science Citations: 0
Abstract

Low frequency ultrasound (LFU) enhances skin permeability via the formation of heterogeneous localized transport regions (LTRs). In this work, hydrogels with different zeta potentials were used as the coupling medium for LFU to investigate their contribution to LTR patterns and to the skin penetration of two model drugs, calcein and doxorubicin (DOX). When hydrogels were used, LTRs covering at least a 3-fold greater skin area were observed compared to those resulting from traditional LFU treatment and sodium lauryl sulfate. More LTRs resulted in an enhancement of calcein skin permeation. The zeta potential of the hydrogels affected the skin penetration of the positively charged DOX; the cationic coupling medium decreased the DOX recovered from the viable epidermis by 2.8-fold, whereas the anionic coupling medium increased the DOX accumulation in the stratum corneum by 4.4-fold. Therefore, LFU/hydrogel treatment increases LTRs areas and can target ionized drugs to specific skin layers depending on the zeta potential of the coupling medium. (AU)

FAPESP's process: 14/22451-7 - Sustained drug delivery systems targeting the epithelial tissue
Grantee:Renata Fonseca Vianna Lopez
Support type: Research Projects - Thematic Grants
FAPESP's process: 11/06202-9 - Influence of low frequency sonophoresis on skin penetration of nanoparticles aiming the skin cancer treatment
Grantee:Renata Fonseca Vianna Lopez
Support type: Regular Research Grants
FAPESP's process: 10/20794-3 - Influence of low frequency ultrasound (LFU) associated with different coupling medium in skin permeability and topical skin cancer treatment
Grantee:Tatiana Aparecida Pereira
Support type: Scholarships in Brazil - Doctorate