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Debora Aparecida Pires de Campos Zuccari

Secretaria de Desenvolvimento Econômico, Ciência e Tecnologia (São Paulo - Estado). Faculdade de Medicina de São José do Rio Preto (FAMERP)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil
*Updated in March 24, 2015
Debora Aparecida Pires de Campos Zuccari in research grants and scholarships supported by FAPESP.

Citation indices (Source: Google Scholar)*

AllSince 2010
Citations235191
h-index98
i10-index98
200720082009201020112012201320142015
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Publication list
Source: Google Scholar
*Updated daily

Ongoing research grants (most recent)

  • Prognostic value of vascular endothelial growth factor and hypoxia-inducible factor 1A in canine malignant mammary tumors, PUB.ART

    Prognostic value of vascular endothelial growth...

    Mammary tumors are the most common type of tumor in dogs, with approximately half of these tumors are malignant. Hypoxia, characterized by oxygen levels below normal, is a known adverse factor to cancer treatment. The hypoxia-inducible factor 1a (HIF -1a) is a central regulator of pathophysiological response of mammalian cells to low oxygen levels; it activates the transcription of the...

  • Evaluation of melatonin treatment in primary culture of canine mammary tumors, PUB.ART

    Evaluation of melatonin treatment in primary cu...

    Mammary neoplasias are the most common tumors observed in female dogs. Identification of these tumors is valuable in order to identify beneficial therapeutic agents as alternative treatments for this tumor type. Oral administration of melatonin appears to exert an oncostatic effect on mammary neoplasia and may have a possible mechanism of action through its interaction with estrogen rec...

Completed research grants (most recent)

See more Completed research grants (Only some records are available in English at this moment)

Ongoing scholarships in Brazil (most recent)

  • NF-kB and VEGF expression in animal model of breast cancer after melatonin treatment, BP.IC

    NF-kB and VEGF expression in animal model of br...

    Breast cancer is the most common cancer in women being ranked as the second most frequent cancer in the world. Tumor growth requires the formation of new vessels that are stimulated by vascular endothelial growth factor (VEGF), whose expression can be regulated by nuclear transcription factor (NF-kB). Thus, molecules involved in angiogenesis are a major target for new therapeutic agents...

  • Radiomics and transcriptomics analysis of breast cancer in an animal model after melatonin treatment, BP.PD

    Radiomics and transcriptomics analysis of breas...

    Breast cancer is the most common cancer in women being rated as the second most frequent type of cancer in the world. Melatonin is a hormone naturally produced by the pineal gland and currently has been related to cancer. Studies suggest its therapeutic use in different types of cancer, but still need a better understanding of their mechanisms of action and oncostatic effects. In this c...

  • Value of diagnosis and prognosis of serum concentration of melatonin in women with breast cancer, BP.IC

    Value of diagnosis and prognosis of serum conce...

    Breast cancer is the most common cancer in women, responsible for about a third of new diagnoses and the leading cause of death from cancer in women in Brazil and worldwide. An increasing variety of molecular markers have been identified, and can be used in conjunction with the morphological and histological markers to more accurate assessment of the diagnosis and prognosis of cancer pa...

See more Ongoing scholarships in Brazil (Only some records are available in English at this moment)

Completed scholarships in Brazil (most recent)

  • Verification of apoptotic proteins in response of melatonin treatment in co-culture of fibroblasts and mammary tumor cell line, BP.IC

    Verification of apoptotic proteins in response ...

    Breast cancer is the most common cancer in women. In recent years, it has been shown that cancer progression occurs not only because of the changes on tumor cells but also the changes on microenvironment. Cancer-associated fibroblasts (CAF) are the most abundant cells in the tumor microenvironment and they are able to mediate responses that promote tumor development. The hormone melaton...

  • Evaluation of the treatment effect with melatonin in breast tumor stem cells, BP.IC

    Evaluation of the treatment effect with melaton...

    Breast cancer is a neoplasia that would affects more women worldwide, with high mortality rates. These high rates occur due to acquired resistance to certain treatments for patients, allowing the recurrence and / or tumor growth, invasion and metastasis, representing the main causes of death by disease. Recently, it was discovered the existence of "tumor stem cells" (TSCs) in human tumo...

  • Evaluation of the ONCONSTATIC action of melatonin in breast cancer cell line MCF-7 treated with estrogenic disruptors, BP.IC

    Evaluation of the ONCONSTATIC action of melaton...

    The high incidence of breast cancer is due to a number of factors, including use of hormones such as estradiol, and exposure to chemicals, including bisphenol A, both considered estrogenic disruptors, which can contribute to the development of neoplasms mammary, increasing malignancy of cell by binding to the estrogen receptor. In this feeling, the identification of therapeutic agents t...

See more Completed scholarships in Brazil (Only some records are available in English at this moment)

Completed scholarships abroad (most recent)

  • Actions of melatonin and ionizing radiation on proteins related with angiogenesis in human breast cancer cells, BE.EP.IC

    Actions of melatonin and ionizing radiation on ...

    Breast cancer is the most common and major cause of death by this disease among women worldwide. Many studies are being conducted to factors that control growth, death and cell proliferation besides angiogenesis. VEGF (vascular endothelial growth factor) is essential for the creation of new blood vessels and has been associated with tumor growth and proliferation. On the other hand, Ang...

  • Regulatory action of melatonin on miR-17 and ROCK-1 in breast cancer metastatization, BE.EP.IC

    Regulatory action of melatonin on miR-17 and RO...

    Breast cancer is the most common neoplasia in women and has been frequently associated to high morbidities and mortalities rates, with great financial impact on heath systems. Besides, the disease is characterized by the high rates of metastasis, which worsen significantly the prognosis. This process is associated with two regulatory molecules, microRNAs (miRNAs), specially miR-17, and ...

  • Metastasis inhibition via epithelial-mesenchymal transition by metformin in mammary neoplasia, BE.EP.DR

    Metastasis inhibition via epithelial-mesenchyma...

    The Epithelial-mesenchymal transition (EMT) is characterized by the change in mesenchymal to epithelial phenotype leads to loss or reduced expression of markers of epithelial cells such as E-cadherin and claudin, and increased expression of markers of mesenchymal cells such as n- cadherin and vimentin, as well as increased expression of the transcription factor twist. The EMT can be ind...

See more Completed scholarships abroad (Only some records are available in English at this moment)

Scientific publications resulting from Awards and Scholarships under his responsibility (9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications7
Citations12
Cit./Article1.7
Data from Web of Science

BORIN, THAIZ FERRAZ; ZUCCARI, DEBORA A. P. C.; JARDIM-PERASSI, BRUNA V.; FERREIRA, LIVIA C.; ISKANDER, A. S. M.; VARMA, NADIMPALLI RAVI S.; SHANKAR, ADARSH; GUO, AUSTIN M.; SCICLI, GUILLERMO; ARBAB, ALI S.. HET0016, a Selective Inhibitor of 20-HETE Synthesis, Decreases Pro-Angiogenic Factors and Inhibits Growth of Triple Negative Breast Cancer in Mice. PLoS ONE, v. 9, n. 12, . Web of Science Citations: 0. (12/12114-8)

JARDIM-PERASSI, BRUNA VICTORASSO; ARBAB, ALI S.; FERREIRA, LIVIA CARVALHO; BORIN, THAIZ FERRAZ; VARMA, NADIMPALLI R. S.; ISKANDER, A. S. M.; SHANKAR, ADARSH; ALI, MESER M.; PIRES DE CAMPOS ZUCCARI, DEBORA APARECIDA. Effect of Melatonin on Tumor Growth and Angiogenesis in Xenograft Model of Breast Cancer. PLoS ONE, v. 9, n. 1, . Web of Science Citations: 7. (11/01054-1, 12/05065-0, 11/01052-9)

BOTTINO, JENIFER; GELALETI, GABRIELA BOTTARO; MASCHIO, LARISSA BAZELA; JARDIM-PERASSI, BRUNA VICTORASSO; PIRES DE CAMPOS ZUCCARI, DEBORA APARECIDA. Immunoexpression of ROCK-1 and MMP-9 as prognostic markers in breast cancer. ACTA HISTOCHEMICA, v. 116, n. 8, p. 1367-1373, . Web of Science Citations: 0. (11/13154-0)

ZUCCARI, D. A. P. C.; CASTRO, R.; GAVIOLI, A. F.; MANCINI, U. M.; FRADE, C. S.; LEONEL, C.. Immunohistochemical and molecular analysis of caveolin-1 expression in canine mammary tumors. Genetics and Molecular Research, v. 11, n. 1, p. 153-165, . Web of Science Citations: 2.

ZUCCARI, D. A. P. C.; CASTRO, R.; JARDIM, B. V.; MANCINI, U. M.; POLACHINI, G. M.. Immunohistochemical and molecular expression of laminin-332 gamma-2 chain in canine mammary tumors. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v. 63, n. 1, p. 28-35, . Web of Science Citations: 0.

ZUCCARI, D. A. P. C.; CASTRO, R.; GELALETI, G. B.; MANCINI, U. M.. Interleukin-8 expression associated with canine mammary tumors. Genetics and Molecular Research, v. 10, n. 3, p. 1522-1532, . Web of Science Citations: 3.

ZUCCARI, DEBORA A. P. C.; CASTRO, RODRIGO; GAVIOLI, ARIELI F.; MANCINI, ULISES M.; TAJARA, ELOISA H.; FRADE, CIBELLI S.; PIVARO, LUANA R.; CARMONA-RAPHE, JULIANA; TERZIAN, ANA CAROLINA B.; RUIZ, CAMILA M.; et al. The maspin expression in canine mammary tumors: An immunohistochemical and molecular study. Pesquisa Veterinária Brasileira, v. 29, n. 2, p. 167-173, . Web of Science Citations: 0.

DEBORA A.P.C. ZUCCARI; MARCILIA V. PAVAM; CAROLINA B. TERZIAN; RODRIGO S. PEREIRA; CAMILA M. RUIZ; JOANNA COELHO ANDRADE. Immunohistochemical evaluation of e-cadherin, Ki-67 and PCNA in canine mammary neoplasias: correlation of prognostic factors and clinical outcome. Pesquisa Veterinária Brasileira, v. 28, n. 4, p. 207-215, .

BERNARDES‚ A.C.; ZUCCARI‚ C.; PEREIRA‚ R.S.; PAVAM‚ M.V.; RUIZ‚ C.M.. Avaliação da caspase-3 e Ki-67 como marcadores prognósticos nas neoplasias mamárias em cadelas. Brazilian Journal of Veterinary Research and Animal Science, v. 44, n. 2, p. 96-102, .

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