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Photo of Debora Aparecida Pires de Campos Zuccari
Source: Lattes Curriculum

Debora Aparecida Pires de Campos Zuccari

Secretaria de Desenvolvimento Econômico, Ciência e Tecnologia (São Paulo - Estado). Faculdade de Medicina de São José do Rio Preto (FAMERP)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil
*Updated in September 24, 2016

Contact researcher

graduate at Veterinary Medicine from Universidade Estadual Paulista Júlio de Mesquita Filho (1986), master's at Patologia Veterinária from Universidade Estadual Paulista Júlio de Mesquita Filho (1999) and ph.d. at Medicina Veterinária Clínica Médica Jaboticabal from Universidade Estadual Paulista Júlio de Mesquita Filho (2001). Has experience in Veterinary Medicine, focusing on Animal Clinical Pathology, acting on the following subjects: imuno-histoquímica, cadelas, neoplasia mamária, diagnóstico and cadela. (Source: Lattes Curriculum)

Citation indices (Source: Google Scholar Sept. 8, 2016, 9:19 a.m.)*

TodosDesde 2011
Citações433378
Índice h1110
Índice i101110
200820092010201120122013201420152016
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Publication list
Source: Google Scholar
*Weekly updated

Ongoing research grants (most recent)

  • Effect of melatonin in epithelial mesenchymal transition markers and invasive properties of breast cancer stem cells of canine and human cell lines, PUB.ART

    Effect of melatonin in epithelial mesenchymal t...

    Cancer stem cells (CSCs) have been associated with metastasis and therapeutic resistance and can be generated via epithelial mesenchymal transition (EMT). Some studies suggest that the hormone melatonin acts in CSCs and may participate to the inhibition of the EMT. The objectives of this study were to evaluate the formation of mammospheres from the canine and human breast cancer cell li...

  • Melatonin and miRNAs in triple negative breast cancer, AP.R

    Melatonin and miRNAs in triple negative breast ...

    Breast cancer is the most prevalent type of tumor among women. The stages of initiation, progression and tumor invasion are triggered by genetic changes in tumor cells, that also receive influence of inflammatory and angiogenic factors released in the tumor microenvironment. MicroRNAs (miRNAs) are small non-coding mRNA molecules that play an important role in gene regulation. Several mi...

Completed research grants (most recent)

  • European Cancer Congress 2015, AR.EXT
  • Prognostic value of vascular endothelial growth factor and hypoxia-inducible factor 1A in canine malignant mammary tumors, PUB.ART

    Prognostic value of vascular endothelial growth...

    Mammary tumors are the most common type of tumor in dogs, with approximately half of these tumors are malignant. Hypoxia, characterized by oxygen levels below normal, is a known adverse factor to cancer treatment. The hypoxia-inducible factor 1a (HIF -1a) is a central regulator of pathophysiological response of mammalian cells to low oxygen levels; it activates the transcription of the...

  • Evaluation of melatonin treatment in primary culture of canine mammary tumors, PUB.ART

    Evaluation of melatonin treatment in primary cu...

    Mammary neoplasias are the most common tumors observed in female dogs. Identification of these tumors is valuable in order to identify beneficial therapeutic agents as alternative treatments for this tumor type. Oral administration of melatonin appears to exert an oncostatic effect on mammary neoplasia and may have a possible mechanism of action through its interaction with estrogen rec...

See more Completed research grants (Only some records are available in English at this moment)

Ongoing scholarships in Brazil (most recent)

  • Relation between melatonin and Vitamin D serum in breast cancer women and its therapeutics actions in vitro study, BP.IC

    Relation between melatonin and Vitamin D serum ...

    Breast cancer is the neoplasia with major prevalence and mortality in women worldwide, and in 2014, it was estimated 57,120 new cases in Brazil. It has been established the relation between the occurrence of breast cancer and disruption of the circadian cycle, and thereby, vitamin D and melatonin have special importance. The production of melatonin follows a rhythmic pattern dependent o...

  • Melatonin action in miRNA-155 expression in lineage of metastatic breast cancer, BP.IC

    Melatonin action in miRNA-155 expression in lin...

    MicroRNAs are small non-coding RNA molecules that play a key role in gene regulation. The expression of miRNAs is associated with tumor growth, invasion, angiogenesis and metastasis of various types of cancer, such as breast cancer. During the tumor development, angiogenesis, the formation of new blood vessels, displays a vital role, allowing tumor progression and metastasis. Therefore,...

  • Melatonin effect on modulation of MIRNA-200 on metastatic breast cancer cell line, BP.IC

    Melatonin effect on modulation of MIRNA-200 on ...

    Breast cancer is the most common type and the second leading cause of death in women worldwide. Metastasis can occur by different mechanisms, and currently microRNAs (miRNAs) are being investigated as possible determinants of this process. Recent studies show that miRNAs have a significant role in regulating gene expression during the differentiation processes, cell cycle progression an...

See more Ongoing scholarships in Brazil (Only some records are available in English at this moment)

Completed scholarships in Brazil (most recent)

  • Action of melatonin in intratumoral heterogeneity by checking markers carbonic anhydrase IX and XII in an animal model of breast cancer, BP.IC

    Action of melatonin in intratumoral heterogenei...

    Breast cancer is considered common in women, has tumor growth and metastasis, the major cause of evolution and death of patients. The greedy tumor growth hampers the blood perfusion in some areas resulting in focus of hypoxia, which may exert a selective pressure on the tumor selecting subsets with advantageous features, just to survive in low oxygen environments. Each subpopulation has...

  • NF-kB and VEGF expression in animal model of breast cancer after melatonin treatment, BP.IC

    NF-kB and VEGF expression in animal model of br...

    Breast cancer is the most common cancer in women being ranked as the second most frequent cancer in the world. Tumor growth requires the formation of new vessels that are stimulated by vascular endothelial growth factor (VEGF), whose expression can be regulated by nuclear transcription factor (NF-kB). Thus, molecules involved in angiogenesis are a major target for new therapeutic agents...

  • Melatonin effect on intratumor heterogeneity by hypoxia immunohistochemistry markers in animal model of breast cancer, BP.IC

    Melatonin effect on intratumor heterogeneity by...

    Breast cancer is considered the most common neoplasm among women and the tumor growth is the major cause of evolution and mortality of patients. The large tumor extension hinders the perfusion of O2, mainly in the central region of the tumor. This results in hipoxic regions, which cause a selective pressure on the tumor, selecting subpopulations with advantageous characteristics to surv...

See more Completed scholarships in Brazil (Only some records are available in English at this moment)

Ongoing scholarships abroad (most recent)

  • Effect of melatonin on the modulation of miRNAs involved in breast cancer metastasis, BE.EP.DR

    Effect of melatonin on the modulation of miRNAs...

    Breast cancer is the most common tumor type in women, and the leading cause of death of these patients is tumor progression and metastasis. microRNAs (miRNAs) are small non-coding mRNA molecules that play a key role in gene regulation. Recent studies have shown that miRNAs are directly involved in the initiation and progression of several tumor types, including breast cancer. Several mi...

  • Radiomic analysis of breast cancer animal model after melatonin treatment, BE.EP.PD

    Radiomic analysis of breast cancer animal model...

    Breast cancer is the most common cancer in women being rated as the second most frequent type of cancer in the world. Solid tumors are recognized by a microenvironment, which is exposed to adverse conditions, such as hypoxia and acidosis that can play selective pressures that drive a natural selection, leading to creating of sub-populations of tumor cells that have selective advantage (...

Completed scholarships abroad (most recent)

  • Actions of melatonin and ionizing radiation on proteins related with angiogenesis in human breast cancer cells, BE.EP.IC

    Actions of melatonin and ionizing radiation on ...

    Breast cancer is the most common and major cause of death by this disease among women worldwide. Many studies are being conducted to factors that control growth, death and cell proliferation besides angiogenesis. VEGF (vascular endothelial growth factor) is essential for the creation of new blood vessels and has been associated with tumor growth and proliferation. On the other hand, Ang...

  • Regulatory action of melatonin on miR-17 and ROCK-1 in breast cancer metastatization, BE.EP.IC

    Regulatory action of melatonin on miR-17 and RO...

    Breast cancer is the most common neoplasia in women and has been frequently associated to high morbidities and mortalities rates, with great financial impact on heath systems. Besides, the disease is characterized by the high rates of metastasis, which worsen significantly the prognosis. This process is associated with two regulatory molecules, microRNAs (miRNAs), specially miR-17, and ...

  • Metastasis inhibition via epithelial-mesenchymal transition by metformin in mammary neoplasia, BE.EP.DR

    Metastasis inhibition via epithelial-mesenchyma...

    The Epithelial-mesenchymal transition (EMT) is characterized by the change in mesenchymal to epithelial phenotype leads to loss or reduced expression of markers of epithelial cells such as E-cadherin and claudin, and increased expression of markers of mesenchymal cells such as n- cadherin and vimentin, as well as increased expression of the transcription factor twist. The EMT can be ind...

See more Completed scholarships abroad (Only some records are available in English at this moment)

Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (12)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications10
Citations45
Cit./Article4.5
Data from Web of Science

ZUCCARI, D. A. P. C.; CASTRO, R.; GELALETI, G. B.; MANCINI, U. M.. Interleukin-8 expression associated with canine mammary tumors. Genetics and Molecular Research, v. 10, n. 3, p. 1522-1532, . Web of Science Citations: 4.

BERNARDES‚ A.C.; ZUCCARI‚ C.; PEREIRA‚ R.S.; PAVAM‚ M.V.; RUIZ‚ C.M.. Avaliação da caspase-3 e Ki-67 como marcadores prognósticos nas neoplasias mamárias em cadelas. Brazilian Journal of Veterinary Research and Animal Science, v. 44, n. 2, p. 96-102, .

ZUCCARI, DEBORA A. P. C.; CASTRO, RODRIGO; GAVIOLI, ARIELI F.; MANCINI, ULISES M.; TAJARA, ELOISA H.; FRADE, CIBELLI S.; PIVARO, LUANA R.; CARMONA-RAPHE, JULIANA; TERZIAN, ANA CAROLINA B.; RUIZ, CAMILA M.; et al. The maspin expression in canine mammary tumors: An immunohistochemical and molecular study. Pesquisa Veterinária Brasileira, v. 29, n. 2, p. 167-173, . Web of Science Citations: 0.

MOSCHETTA, MARINA GOBBE; MASCHIO, LARISSA BAZELA; JARDIM-PERASSI, BRUNA VICTORASSO; GELALETI, GABRIELA BOTTARO; LOPES, JULIANA RAMOS; LEONEL, CAMILA; GONCALVES, NAIANE DO NASCIMENTO; FERREIRA, LIVIA CARVALHO; MARTINS, GUSTAVO RODRIGUES; BORIN, THAIZ PERRAZ; et al. Prognostic value of vascular endothelial growth factor and hypoxia-inducible factor 1 alpha in canine malignant mammary tumors. ONCOLOGY REPORTS, v. 33, n. 5, p. 2345-2353, . Web of Science Citations: 1. (10/13977-4, 09/14883-6)

BOTTINO, JENIFER; GELALETI, GABRIELA BOTTARO; MASCHIO, LARISSA BAZELA; JARDIM-PERASSI, BRUNA VICTORASSO; PIRES DE CAMPOS ZUCCARI, DEBORA APARECIDA. Immunoexpression of ROCK-1 and MMP-9 as prognostic markers in breast cancer. ACTA HISTOCHEMICA, v. 116, n. 8, p. 1367-1373, . Web of Science Citations: 7. (11/13154-0)

BORIN, THAIZ FERRAZ; ZUCCARI, DEBORA A. P. C.; JARDIM-PERASSI, BRUNA V.; FERREIRA, LIVIA C.; ISKANDER, A. S. M.; VARMA, NADIMPALLI RAVI S.; SHANKAR, ADARSH; GUO, AUSTIN M.; SCICLI, GUILLERMO; ARBAB, ALI S.. HET0016, a Selective Inhibitor of 20-HETE Synthesis, Decreases Pro-Angiogenic Factors and Inhibits Growth of Triple Negative Breast Cancer in Mice. PLoS One, v. 9, n. 12, . Web of Science Citations: 4. (12/12114-8)

JARDIM-PERASSI, BRUNA VICTORASSO; ARBAB, ALI S.; FERREIRA, LIVIA CARVALHO; BORIN, THAIZ FERRAZ; VARMA, NADIMPALLI R. S.; ISKANDER, A. S. M.; SHANKAR, ADARSH; ALI, MESER M.; PIRES DE CAMPOS ZUCCARI, DEBORA APARECIDA. Effect of Melatonin on Tumor Growth and Angiogenesis in Xenograft Model of Breast Cancer. PLoS One, v. 9, n. 1, . Web of Science Citations: 25. (11/01054-1, 12/05065-0, 11/01052-9)

DEBORA A.P.C. ZUCCARI; MARCILIA V. PAVAM; CAROLINA B. TERZIAN; RODRIGO S. PEREIRA; CAMILA M. RUIZ; JOANNA COELHO ANDRADE. Immunohistochemical evaluation of e-cadherin, Ki-67 and PCNA in canine mammary neoplasias: correlation of prognostic factors and clinical outcome. Pesquisa Veterinária Brasileira, v. 28, n. 4, p. 207-215, .

ZUCCARI, D. A. P. C.; CASTRO, R.; GAVIOLI, A. F.; MANCINI, U. M.; FRADE, C. S.; LEONEL, C.. Immunohistochemical and molecular analysis of caveolin-1 expression in canine mammary tumors. Genetics and Molecular Research, v. 11, n. 1, p. 153-165, . Web of Science Citations: 3.

ZUCCARI, D. A. P. C.; CASTRO, R.; JARDIM, B. V.; MANCINI, U. M.; POLACHINI, G. M.. Immunohistochemical and molecular expression of laminin-332 gamma-2 chain in canine mammary tumors. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v. 63, n. 1, p. 28-35, . Web of Science Citations: 0.

BORIN, THAIZ FERRAZ; ARBAB, ALI SYED; GELALETI, GABRIELA BOTTARO; FERREIRA, LIVIA CARVALHO; MOSCHETTA, MARINA GOBBE; JARDIM-PERASSI, BRUNA VICTORASSO; ISKANDER, A. S. M.; VARMA, NADIMPALLI RAVI S.; SHANKAR, ADARSH; COIMBRA, VERENA BENEDICK; et al. Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1 expression. Journal of Pineal Research, v. 60, n. 1, p. 3-15, . Web of Science Citations: 1. (11/13154-0, 11/20850-3, 11/18986-4, 12/12114-8, 11/18987-0)

MARTINS, GUSTAVO RODRIGUES; GELALETI, GABRIELA BOTTARO; MOSCHETTA, MARINA GOBBE; MASCHIO-SIGNORINI, LARISSA BAZELA; PIRES DE CAMPOS ZUCCARI, DEBORA AP. Proinflammatory and Anti-Inflammatory Cytokines Mediated by NF-kappa B Factor as Prognostic Markers in Mammary Tumors. Mediators of Inflammation, . Web of Science Citations: 0. (12/06098-0)

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