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Photo of Licio Augusto Velloso
Source: Lattes Curriculum

Licio Augusto Velloso

Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas (FCM)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil
FAPESP support in numbers
(Total / Available in English)
3 / 2Ongoing research grants 
8 / 4Completed research grants 
7 / 7Ongoing scholarships in Brazil 
55 / 12Completed scholarships in Brazil 
4 / 4Ongoing scholarships abroad 
3 / 2Completed scholarships abroad 
80 / 31 All Research Grants and Scholarships
*Updated in March 18, 2017

Contact researcher

MD obtained from the University of Campinas in 1986, PhD from Uppsala University, Sweden in 1993. Pos-doc fellow at Campinas University and Harvard University. Currently Full Professor of Medicine, University of Campinas. Former member of the Editorial Board of Clinical Endocrinology. Current member of the Editorial Board International Journal of Obesity. Research field, obesity and diabetes. (Source: Lattes Curriculum)

Citation indices (Source: Google Scholar Sept. 7, 2016, 9:43 a.m.)

AllSince 2011
Publication list
Source: Google Scholar
* Para visualizar os dados atualizados: Clique Aqui

Ongoing research grants (most recent)

  • Protein Kinase Chemical Biology Center: supporting drug development through open-access research, AP.PITE


    Mais de 500 proteínas quinases estão presentes no genoma humano, atuando como chaves regulatórias de praticamente todos os processos fisiológicos do organismo humano. As quinases podem ser moduladas através de pequenas moléculas químicas altamente potentes. No entanto, apesar de sua importância e adequação para a descoberta de fármacos, a maioria das pesquisas acadêmicas e farmacêuticas...

  • OCRC - Obesity and Comorbidities Research Center, AP.CEPID


    Obesity affects more than 400 million subjects in the world and projections for the next 15 years predict an overall prevalence of up to 20%. In developing countries, such as Brazil a rapid nutritional transition provided by the recent economical growth has led to a unique condition on which the malnourished persist in parallel with an increasing number of obese subjects. It is expected...

Completed research grants (most recent)

  • Program for the visiting professor Franco Battista Ennio Folli, AV.EXT

    Program for the visiting professor Franco Batti...

    Prof. Folli will provide advices to several ongoing projects in the following groups of professors: Lício A. Velloso, Mario J. A. Saad, Antônio C. Boschero, Everardo M. Carneiro e José B. Carvalheira. This Professor has a huge experience in insulin resistance and insulin secretion areas and he must contribute considerably for the development of the projects aforementioned. Prof. Folli w...

  • Inflammation and immune response in obesity, AP.TEM


    Obesity results from the progressive 1055 of the homeostatic control of food intake and energy expenditure. Genetic and environmental factors contribute for the complex pathogenesis of this disease. However, in spite of the considerable advance obtained in the understanding of the mechanisms involved in the control of hunger and thermogenesis, this has provided no major breakthrough in ...

  • Post-inflammatory mechanisms involved in the hypothalamic control of hunger and hermogenesis - implications for the physiopathology of obesity, Diabetes mellitus and cachexia, AP.TEM


    In recent decades there has been a surprising increase in the prevalence of obesity and type 2 diabetes mellitus. Therapy based on behavioral and alimentary modification, and in the use of the few medicines available have not been sufficient to contain the advance of this epidemic. The characterization of the epithalamic mechanisms participating in the control of hunger and thermogenesi...

See more Completed research grants (Only some records are available in English at this moment)

Ongoing scholarships in Brazil (most recent)

See more Ongoing scholarships in Brazil (Only some records are available in English at this moment)

Completed scholarships in Brazil (most recent)

See more Completed scholarships in Brazil (Only some records are available in English at this moment)

Ongoing scholarships abroad (most recent)

  • Characterization of mechanisms involved on early regulation of POMC neurons in response to saturated fatty acids, BE.EP.PD

    Characterization of mechanisms involved on earl...

    The development of obesity is due to association between genetic, metabolic and hormones factors. As consequence it's contribute to insulin resistance, cardiovascular diseases, hypertension, dyslipidemia and certain types of cancer. Obesity affects more than 500 million human worldwide which represent one of the most clinical-epidemiological phenomenon currently. In the past ten years ...

  • The role of CD1 in high fat induced hypothalamic inflamation in mice, BE.EP.DR

    The role of CD1 in high fat induced hypothalami...

    Obesity is the main factor for many diseases, including metabolic syndrome associated disorders such as diabetes,atherosclerosis and some types of cancer. The activation of a subclinical inflammatory process in the hypothalamus hasbeen shown to be one of the major triggerevents that leads to health disturbance associated with weight gain.Thisimmune process involves both genetic and envi...

  • The impact of inhibiton of transcription factor IRX3 in AgRP or POMC neurons in energy metabolism, BE.EP.PD

    The impact of inhibiton of transcription factor...

    A recent study has shown that dietary fats promote obesity not only because of their caloric value but also due to damage in hypothalamic neuronal circuitries that control whole body energy homeostasis. The transcription factor IRX3 can modulate FTO expression, thus, playing a role in the development of obesity. However, the effect of high fat diet (HDF) consumption on the regulation of...

See more Ongoing scholarships abroad (Only some records are available in English at this moment)

Completed scholarships abroad (most recent)

  • Evaluation and characterization of insulin secretion and glucose metabolism in response to IL 17 in human and mice, BE.EP.PD

    Evaluation and characterization of insulin secr...

    The intestine is an organ that allows multiple interactions with the external world. It acts as a selectively permeable barrier, permitting the absorption of nutrients, electrolytes, and water while maintaining an effective defense against intraluminal toxins, antigens, and enteric flora (Groschwitz K. R. et. al., 2009). Innate and adaptative immune cells are distributed in the intesti...

  • Leptin resistance in microglia: the role of saturated fats and chaperones, BE.EP.PD

    Leptin resistance in microglia: the role of sat...

    Hypothalamic inflammation is a common feature of experimental obesity. The expression of inflammatory cytokines and activation of intracellular inflammatory signaling is involved in the induction of leptin and insulin resistance in the hypothalamus resulting in abnormal control of feeding and energy expenditure. Microglia, the macrophages of the central nervous system, can be activated ...

Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (32)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Data from Web of Science

MELO, ARINE M.; BENATTI, RAFAELA O.; IGNACIO-SOUZA, LETICIA M.; OKINO, CAROLINE; TORSONI, ADRIANA S.; MILANSKI, MARCIANE; VELLOSO, LICIO A.; TORSONI, MARCIO ALBERTO. Hypothalamic endoplasmic reticulum stress and insulin resistance in offspring of mice dams fed high-fat diet during pregnancy and lactation. Metabolism, v. 63, n. 5, p. 682-692, . Web of Science Citations: 16. (09/50809-5, 11/17656-0)

OLIVEIRA, V.; MARINHO, R.; VITORINO, D.; SANTOS, G. A.; MORAES, J. C.; DRAGANO, N.; SARTORI-CINTRA, A.; PEREIRA, L.; CATHARINO, R. R.; DA SILVA, A. S. R.; et al. Diets Containing alpha-Linolenic (omega 3) or Oleic (omega 9) Fatty Acids Rescues Obese Mice From Insulin Resistance. Endocrinology, v. 156, n. 11, p. 4033-4046, . Web of Science Citations: 6. (12/07129-6)

MENDES, MARIA CAROLINA S.; PIMENTEL, GUSTAVO D.; COSTA, FELIPE O.; CARVALHEIRA, JOSE B. C.. Molecular and neuroendocrine mechanisms of cancer cachexia. Journal of Endocrinology, v. 226, n. 3, p. R29-R43, . Web of Science Citations: 6. (13/07607-8, 14/22347-5)

ZAMBOM DE SOUZA, ALESSANDRA ZANIN; ZAMBOM, ADRIANO ZANIN; ABBOUD, KAHLILE YOUSSEF; REIS, SABRINA KAREN; TANNIHAO, FABIANA; GUADAGNINI, DIOZE; SAAD, MARIO J. A.; PRADA, PATRICIA OLIVEIRA. Oral supplementation with L-glutamine alters gut microbiota of obese and overweight adults: A pilot study. NUTRITION, v. 31, n. 6, p. 884-889, . Web of Science Citations: 6. (12/10338-6, 13/07607-8)

DE SOUZA, GABRIELA F. P.; NOVAES, LUIZ F. T.; AVILA, CAROLINA M.; NASCIMENTO, LUCAS F. R.; VELLOSO, LICIO A.; PILLI, RONALDO A.. (-)-Tarchonanthuslactone Exerts a Blood Glucose-Increasing Effect in Experimental Type 2 Diabetes Mellitus. Molecules, v. 20, n. 3, p. 5038-5049, . Web of Science Citations: 1. (13/07607-8, 12/09254-2, 10/08673-6)

DE SOUZA, GABRIELA F. P.; TALADRIZ-BLANCO, PATRICIA; VELLOSO, LICIO A.; DE OLIVEIRA, MARCELO G.. Nitric Oxide Released from Luminal S-Nitroso-N-Acetylcysteine Increases Gastric Mucosal Blood Flow. Molecules, v. 20, n. 3, p. 4109-4123, . Web of Science Citations: 3. (13/07173-8, 08/57560-0)

BENATTI, R. O.; MELO, A. M.; BORGES, F. O.; IGNACIO-SOUZA, L. M.; SIMINO, L. A. P.; MILANSKI, M.; VELLOSO, L. A.; TORSONI, M. A.; TORSONI, A. S.. Maternal high-fat diet consumption modulates hepatic lipid metabolism and microRNA-122 (miR-122) and microRNA-370 (miR-370) expression in offspring. BRITISH JOURNAL OF NUTRITION, v. 111, n. 12, p. 2112-2122, . Web of Science Citations: 18. (11/13947-0, 11/22156-7)

NOVAES, LUIZ F. T.; SAROTTI, ARIEL M.; PILLI, RONALDO A.. Total Synthesis and Tentative Structural Elucidation of Cryptomoscatone E3: Interplay of Experimental and Computational Studies. Journal of Organic Chemistry, v. 80, n. 24, p. 12027-12037, . Web of Science Citations: 5. (13/07607-8, 09/51602-5)

BOUCHARD, CLAUDE; ANTUNES-CORREA, LIGIA M.; ASHLEY, EUAN A.; FRANKLIN, NINA; HWANG, PAUL M.; MATTSSON, C. MIKAEL; NEGRAO, CARLOS E.; PHILLIPS, SHANE A.; SARZYNSKI, MARK A.; WANG, PING-YUAN; et al. Personalized Preventive Medicine: Genetics and the Response to Regular Exercise in Preventive Interventionse. PROGRESS IN CARDIOVASCULAR DISEASES, v. 57, n. 4, p. 337-346, . Web of Science Citations: 7. (13/07607-8, 13/15651-7, 10/50048-1)

KURAUTI, MIRIAN A.; COSTA-JUNIOR, JOSE M.; FERREIRA, SANDRA M.; DOS SANTOS, GUSTAVO J.; PROTZEK, ANDRE O. P.; NARDELLI, TARLLIZA R.; DE REZENDE, LUIZ F.; BOSCHERO, ANTONIO C.. Acute exercise restores insulin clearance in diet-induced obese mice. Journal of Endocrinology, v. 229, n. 3, p. 221-232, . Web of Science Citations: 0. (13/07607-8, 13/21283-0)

CONDES AREIAS, MARIA FERNANDA; PRADA, PATRICIA OLIVEIRA. Mechanisms of insulin resistance in the amygdala: Influences on food intake. Behavioural Brain Research, v. 282, p. 209-217, . Web of Science Citations: 8. (12/10338-6, 13/07607-8)

PORTOVEDO, MARIANA; IGNACIO-SOUZA, LETICIA M.; BOMBASSARO, BRUNA; COOPE, ANDRESSA; REGINATO, ANDRESSA; RAZOLLI, DANIELA S.; TORSONI, MARCIO A.; TORSONI, ADRIANA S.; LEAL, RAQUEL F.; VELLOSO, LICIO A.; et al. Saturated Fatty Acids Modulate Autophagy's Proteins in the Hypothalamus. PLoS One, v. 10, n. 3, . Web of Science Citations: 5. (11/14565-4)

CARNEIRO, VANIA M. T.; TRIVELLA, DANIELA B. B.; SCORSATO, VALERIA; BERALDO, VIVIANE L.; DIAS, MARIANA P.; SOBREIRA, TIAGO J. P.; APARICIO, RICARDO; PILLI, RONALDO A.. Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 96, p. 42-54, . Web of Science Citations: 1. (13/07607-8, 10/17544-5, 09/51602-5, 11/00457-5)

PIROVANI, RODRIGO V.; BRITO, GILMAR A.; BARCELOS, ROSIMEIRE C.; PILLI, RONALDO A.. Enantioselective Total Synthesis of (+)-Lyngbyabellin M. MARINE DRUGS, v. 13, n. 6, p. 3309-3324, . Web of Science Citations: 2. (13/07607-8, 10/00219-4, 09/51602-5, 10/00336-0)

WEISSMANN, LAIS; QUARESMA, PAULA G. F.; SANTOS, ANDRESSA C.; DE MATOS, ALEXANDRE H. B.; PASCOAL, VINICIUS D'AVILA BITTENCOURT; ZANOTTO, TAMIRES M.; CASTRO, GISELE; GUADAGNINI, DIOZE; DA SILVA, JOELCIMAR MARTINS; VELLOSO, LICIO A.; et al. IKK epsilon Is Key to Induction of Insulin Resistance in the Hypothalamus, and Its Inhibition Reverses Obesity. Diabetes, v. 63, n. 10, p. 3334-3345, . Web of Science Citations: 2. (12/10338-6, 13/07607-8, 10/52068-0)

SANTOS, G. A.; MOURA, R. F.; VITORINO, D. C.; ROMAN, E. A. F. R.; TORSONI, A. S.; VELLOSO, L. A.; TORSONI, M. A.. Hypothalamic AMPK activation blocks lipopolysaccharide inhibition of glucose production in mice liver. Molecular and Cellular Endocrinology, v. 381, n. 1-2, p. 88-96, . Web of Science Citations: 5. (10/14034-6, 11/17656-0, 09/16775-6)

FERNANDES COSTA, INEZ SILVA; PEREIRA DE SOUZA, GABRIELA FREITAS; DE OLIVEIRA, MARCELO GANZAROLLI; ABRAHAMSOHN, ISES DE ALMEIDA. S-nitrosoglutathione (GSNO) is cytotoxic to intracellular amastigotes and promotes healing of topically treated Leishmania major or Leishmania braziliensis skin lesions. Journal of Antimicrobial Chemotherapy, v. 68, n. 11, p. 2561-2568, . Web of Science Citations: 9.

SANTOS, GUSTAVO A.; PEREIRA, VINICIUS D.; ROMAN, ERIKA A. F. R.; IGNACIO-SOUZA, LETICIA; VITORINO, DANIELE C.; DE MOURA, RODRIGO FERREIRA; RAZOLLI, DANIELA S.; TORSONI, ADRIANA S.; VELLOSO, LICIO A.; TORSONI, MARCIO A.. Hypothalamic Inhibition of Acetyl-CoA Carboxylase Stimulates Hepatic Counter-Regulatory Response Independent of AMPK Activation in Rats. PLoS One, v. 8, n. 4, . Web of Science Citations: 6. (09/12523-2)

MAZO, DANIEL F. C.; DE OLIVEIRA, MARCELO G.; PEREIRA, ISABEL V. A.; COGLIATI, BRUNO; STEFANO, JOSE T.; DE SOUZA, GABRIELA F. P.; RABELO, FABIOLA; LIMA, FABIANA R.; ALVES, VENANCIO A. FERREIRA; CARRILHO, FLAIR J.; et al. S-nitroso-N-acetylcysteine attenuates liver fibrosis in experimental nonalcoholic steatohepatitis. DRUG DESIGN DEVELOPMENT AND THERAPY, v. 7, p. 553-563, . Web of Science Citations: 11.

ZAPPAROLI, ADRIANA; CALEGARI, VIVIAN; VELLOSO, LICIO AUGUSTO; GUADAGNINI, DIOZE; BOER, PATRICIA ALINE; ROCHA GONTIJO, JOSE ANTONIO. Hypothalamic SOCS-3 expression and the effect of intracerebroventricular angiotensin II injection on water intake and renal sodium handling in SHR. Journal of Physiological Sciences, v. 60, n. 6, p. 425-433, . Web of Science Citations: 6.

PAULI, JOSE R.; ROPELLE, EDUARDO R.; CINTRA, DENNYS ESPER; DE SOUZA, CLAUDIO TEODORO; DA SILVA, ADELINO S. R.; MORAES, JULIANA C.; PRADA, PATRICIA O.; DE ALMEIDA LEME, JOSE A. C.; LUCIANO, ELIETE; VELLOSO, LICIO A.; et al. Acute exercise reverses aged-induced impairments in insulin signaling in rodent skeletal muscle. MECHANISMS OF AGEING AND DEVELOPMENT, v. 131, n. 5, p. 323-329, . Web of Science Citations: 22.

PIO-MAGALHAES, J. A.; FERREIRA-SAE, M. C.; SOUZA, F. A.; GRESPAN-MAGOSSI, A. M.; SCHREIBER, R.; VELLOSO, L. A.; GELONEZE, B.; FRANCHINI, K. G.; NADRUZ, JR., W.. Hip circumference is associated with high density lipoprotein cholesterol response following statin therapy in hypertensive subjects. Journal of Endocrinological Investigation, v. 34, n. 9, p. 680-684, . Web of Science Citations: 1.

DA SILVA, ADELINO S. R.; PAULI, JOSE R.; ROPELLE, EDUARDO R.; OLIVEIRA, ALEXANDRE G.; CINTRA, DENNYS E.; DE SOUZA, CLAUDIO T.; VELLOSO, LICIO A.; CARVALHEIRA, JOSE B. C.; SAAD, MARIO J. A.. Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats. Medicine & Science in Sports & Exercise, v. 42, n. 12, p. 2180-2188, . Web of Science Citations: 14.

FRERIA, CAMILA MARQUES; VELLOSO, LICIO AUGUSTO; OLIVEIRA, ALEXANDRE L. R.. Opposing effects of Toll-like receptors 2 and 4 on synaptic stability in the spinal cord after peripheral nerve injury. JOURNAL OF NEUROINFLAMMATION, v. 9, . Web of Science Citations: 17. (10/17688-7, 12/19612-3)

KURAUTI, MIRIAN A.; FREITAS-DIAS, RICARDO; FERREIRA, SANDRA M.; VETTORAZZI, JEAN F.; NARDELLI, TARLLIZA R.; ARAUJO, HYGOR N.; SANTOS, GUSTAVO J.; CARNEIRO, EVERARDO M.; BOSCHERO, ANTONIO C.; REZENDE, LUIZ F.; et al. Acute Exercise Improves Insulin Clearance and Increases the Expression of Insulin-Degrading Enzyme in the Liver and Skeletal Muscle of Swiss Mice. PLoS One, v. 11, n. 7, . Web of Science Citations: 0. (13/07607-8, 14/24719-7)

LEITE, NAYARA CARVALHO; DE PAULA, FLAVIA; BORCK, PATRICIA CRISTINE; VETTORAZZI, JEAN FRANCIESCO; SOUTO BRANCO, RENATO CHAVES; LUBACZEUSKI, CAMILA; BOSCHERO, ANTONIO CARLOS; ZOPPI, CLAUDIO CESAR; CARNEIRO, EVERARDO MAGALHAES. Protein malnutrition potentiates the amplifying pathway of insulin secretion in adult obese mice. SCIENTIFIC REPORTS, v. 6, . Web of Science Citations: 0. (11/19536-2, 13/07607-8, 11/09012-6)

SANTOS, ROBERTA S.; BATISTA, THIAGO M.; CAMARGO, RAFAEL L.; MORATO, PRISCILA N.; BORCK, PATRICIA C.; LEITE, NAYARA C.; KURAUTI, MIRIAN A.; WANSCHEL, AMARYLIS C. B. A.; NADAL, ANGEL; CLEGG, DEBORAH J.; et al. Lacking of estradiol reduces insulin exocytosis from pancreatic beta-cells and increases hepatic insulin degradation. Steroids, v. 114, n. SI, p. 16-24, . Web of Science Citations: 0. (13/07607-8, 15/05801-7)

PEREIRA DE SOUZA, GABRIELA FREITAS; DE OLIVEIRA, MARCELO GANZAROLLI. Intratablet S-nitrosation: A New Approach for the Oral Administration of S-nitrosothiols as Nitric Oxide Donors. Journal of Pharmaceutical Sciences, v. 105, n. 1, p. 359-361, . Web of Science Citations: 0. (08/57560-0)

QUARESMA, P. G. F.; REENCOBER, N.; ZANOTTO, T. M.; SANTOS, A. C.; WEISSMANN, L.; DE MATOS, A. H. B.; LOPES-CENDES, I.; FOLLI, F.; SAAD, M. J. A.; PRADA, P. O.. Pioglitazone treatment increases food intake and decreases energy expenditure partially via hypothalamic adiponectin/adipoR1/AMPK pathway. International Journal of Obesity, v. 40, n. 1, p. 138-146, . Web of Science Citations: 2. (12/10338-6, 13/07607-8)

PASCOAL, LIVIA B.; BOMBASSARO, BRUNA; RAMALHO, ALBINA F.; COOPE, ANDRESSA; MOURA, RODRIGO F.; CORREA-DA-SILVA, FELIPE; IGNACIO-SOUZA, LETICIA; RAZOLLI, DANIELA; DE OLIVEIRA, DIOGO; CATHARINO, RODRIGO; et al. Resolvin RvD2 reduces hypothalamic inflammation and rescues mice from diet-induced obesity. JOURNAL OF NEUROINFLAMMATION, v. 14, . Web of Science Citations: 0. (13/07607-8)

DOS SANTOS, GUSTAVO APARECIDO; FERREIRA, MONICA SIQUEIRA; DE OLIVEIRA, DIOGO NOIN; DE OLIVEIRA, VANESSA; SIQUEIRA-SANTOS, EDILENE S.; CORREA CINTRA, DENNYS ESPER; CASTILHO, ROGER FRIGERIO; VELLOSO, LICIO AUGUSTO; CATHARINO, RODRIGO RAMOS. Identification of compounds from high-fat and extra virgin olive oil-supplemented diets in whole mouse liver extracts and isolated mitochondria using mass spectrometry. Journal of Mass Spectrometry, v. 50, n. 7, p. 951-958, . Web of Science Citations: 2. (14/00084-2, 11/50400-0)

ZANON, R. G.; CARTAROZZI, L. P.; VICTORIO, S. C. S.; MORAES, J. C.; MORARI, J.; VELLOSO, L. A.; OLIVEIRA, A. L. R.. Interferon (IFN) beta treatment induces major histocompatibility complex (MHC) class I expression in the spinal cord and enhances axonal growth and motor function recovery following sciatic nerve crush in mice. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, v. 36, n. 6, p. 515-534, . Web of Science Citations: 16. (09/07443-0, 05/03159-4)

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