CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas (FCM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
MD obtained from the University of Campinas in 1986, PhD from Uppsala University, Sweden in 1993. Pos-doc fellow at Campinas University and Harvard University. Currently Full Professor of Medicine, University of Campinas. Former member of the Editorial Board of Clinical Endocrinology. Current member of the Editorial Board International Journal of Obesity. Associate Editor American Journal of Physiology-Endocrinology and Metabolism. Research field, obesity and diabetes. (Source: Lattes Curriculum)
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Obesity is one of the most prevalent diseases in the world. The advances in prevention, pharmacological and surgical treatment obtained to date have not been sufficient to contain the advance of the disease, which affects not only adults, but an increasing number of children and adolescents. In this project, we will evaluate humans and experimental models in order to identify and characte…
Obesity affects over 600 million people worldwide and, despite recent therapeutic advance in the field, projections estimate a continuous increase of its prevalence over the next decade. In this context, the identification of new targets could improve therapeutic strategies and contribute to revert the current epidemiological scenario. G protein-coupled receptors (GPCRs) are the targets f…
(Only some records are available in English at this moment)
The pandemic of the new severe acute respiratory syndrome virus (SARS-CoV-2) has already been confirmed in more than 330 thousand people, being responsible for more than 14 thousand deaths worldwide (World Health Organization - official data of 23 March 2020). The current treatment for severe cases is based on respiratory support, use of a variety of antibiotics with possible extracorpore…
The main objectives of the project are to elucidate the effect of activation of the long-chain fatty acid receptors FFA4 and FFA1 in the hypothalamus on appetite and obesity; determine the ability of fatty acids in various forms, including as free fatty acids, triacylglycerides, and phospholipids, to reach the central CNS after oral intake and investigate the ability of dietary fatty acid…
(Only some records are available in English at this moment)
Mutations in the Dlk1 gene have been implicated in the regulation of energy metabolism and cellular differentiation, playing a critical role in the development of the central nervous system and neuroendocrine function. However, its function in specific neuronal subpopulations has never been studied. In a preliminary stage of this project, we used bioinformatics tools to identify subpopula…
Obesity is a chronic inflammatory disease defined as the excessive accumulation of adipose tissue. It is suggested that microglia act as sensors and become activated following exposure to high-fat diets (HFD), triggering inflammatory responses that affect hypothalamic neuronal pathways. Additionally, microglial activation is associated with the release of MMPs, enzymes responsible for deg…
Hypothalamic pro-opiomelanocortin neurons act as first-order sensors of systemic signals that reflect the body's energy reserves. In diet-induced obesity, pro-opiomelanocortin neurons are structurally and functionally damaged, resulting in defective regulation of energy balance. It has previously been shown that inducing mild stress in these neurons can protect them from damage caused by …
(Only some records are available in English at this moment)
Neurons in the mediobasal hypothalamus are responsible for coordinating responses to systemic stimuli that indicate the body's energy reserves. In addition to responding to hormones such as leptin and insulin, these neurons are also responsive to nutrients. A nutrient widely consumed in Western-style diets is palmitate, present in animal and vegetal fats, and used in various preparations …
Obesity is currently one of the most prevalent diseases on the planet. Unfortunately, behavioral approaches, which include increasing physical activity combined with reducing caloric intake, have a high rate of refractoriness, and in general, patients are unable to adhere to the recommendations for long periods. In the last decade, the introduction of glucagon-like peptide-1 receptor agon…
Obesity affects more than 600 million people and, according to the World Health Organization, it is one of the most prevalent diseases in the world. Because of its frequent association with diabetes and cardiovascular disease, obesity greatly increases the risk of early death. Socioeconomic changes that have occurred over the last 50 years have led to an increase in the consumption of ene…
(Only some records are available in English at this moment)
In the central nervous system, apoE is the main carrier of cholesterol to neurons via ApoE receptors, promoting the uptake, redistribution, and storage of these molecules, which are essential for maintaining cellular functions such as neuronal growth, organelle biogenesis, membrane repair, and synaptogenesis. Apolipoprotein E has also been linked to energy homeostasis and food intake. Whe…
Obesity affects over 600 million people worldwide and, despite recent therapeutic advance in the field, projections estimate a continuous increase of its prevalence over the next decade. In this context, the identification of new targets could improve therapeutic strategies and contribute to revert the current epidemiological scenario. G protein-coupled receptors (GPCRs) are the targets f…
Background: Lipodystrophy, similar to obesity, is a disease with white adipose tissue dysfunction, but with worse metabolic profile. The inherited lipodystrophies can be classified as generalized or partial, with the extent of adipose tissue loss being associated with the severity of the metabolic complications. Brown adipose tissue has different embryonic origin from WAT and the presence…
The hypothalamus is a key region in the central nervous system that controls different functions such as energy balance, thermogenesis, and reproduction, which are essential to species' adaptation and survival. Adult neurogenesis in the hypothalamus has been known to renew subpopulations of neurons that play central roles in controlling energy homeostasis. Additionally, preliminary studie…
(Only some records are available in English at this moment)
| 5 / 5 | Ongoing grants |
| 13 / 9 | Completed research grants |
| 16 / 16 | Ongoing scholarships in Brazil |
| 122 / 83 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 14 / 13 | Completed scholarships abroad |
| 171 / 127 | All research grants and scholarships |
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