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93,041 result(s)

Dr. Resíduo: waste rational destination

Grant number:11/52000-9
Support type:Research Grants - Program to Support Research in Small Business (PAPPE / PIPE III)
Duration: December 01, 2011 - May 31, 2013
Field of knowledge:Physical Sciences and Mathematics - Computer Science
Cooperation agreement:FINEP - PAPPE-PIPE III
Principal Investigator:Carolina Afonso Pinto
Company:Sistema Ciclo Processamento Ltda. - ME
Associated research grant:06/56611-4 - Rational Waste Consolidation - RWC, AP.PIPE

Ovarian cancer has the highest incidence in peri-and postmenopausal, and due to its late diagnosis and poor prognosis, it is the fourth leading cause of cancer death worldwide, alongside breast, colorectal, lung and cervix cancers. Ovarian cancer initially responds to conventional chemotherapy, slowing the growth of the tumor mass, however, in an unexpected way, many women can develop chemoresistance to specific treatment. It is undisputed that risk factors, such as chronic alcoholism may contribute to tumor aggressiveness, acting as a co-carcinogenic agent. Interestingly, molecular mechanisms related to tumorigenesis and ethanol consumption share the same pathway which promotes the survival and proliferation of tumor cells. Given that melatonin possesses immunomodulatory and oncostatic activities and also seems to inhibit cell proliferation-related Her signaling pathway, this study aims to evaluate the effect of ovarian tumor induction and the influence of melatonin on Her 2 and 4-mediated signaling in the ovaries of rats that voluntarily consume 10% (v/v) ethanol (UChB strain). For this purpose, the following parameters will be investigated: estrous cycle monitoring, evaluation of the frequency and characterization of different types of ovarian tumors through histopathology, immunoreactivity and quantification of Her 2 and 4-target receptors, and proteins/enzymes like phosphatidylinositol 3 kinase (PI3K), AKT protein (protein kinase B), mammalian target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK) using immunohistochemical techniques and Western blot. These results will assist in clarifying the effects of melatonin on the proliferation and survival of tumor cells associated with ovarian cancer. (AU)


Systems based colloidal particles of natural biopolymers are being increasingly used as encapsulation systems or serving active ingredients, or to modulate the sensory properties of food. Most of these applications involve a step of emulsification during processing. The hyperaggregation of the lipid droplets with polysaccharide can be used to create highly viscous emulsions or gels similar to, but with much lower oil content than conventional emulsions. This aggregation is induced by mixing a primary emulsion with stabilizes oil droplets by a protein with a polysaccharide solution at a pH at which the biopolymers have opposite charges. The application of high intensity ultrasound with the aim of changing functional properties of biopolymers has been widely studied and, in addition, the use of ultrasound is one of methods that allow the preparation of emulsions with droplet sizes reduced. Thus, this project aims to evaluate the rheological behavior of emulsions of oil in water (O / W) stabilized by the electrostatic interaction of proteins (protein concentrate of whey, WPC, or soy protein isolate, SPI) and polysaccharides (pectin or alginate), searching for obtaining systems with different textures and possible use as fat substitutes. We will investigate the interaction between the pairs of polysaccharide-protein (WPC / pectin, WPC / alginate, SPI / SPI and pectin / alginate) as a function of pH and ratio protein: polysaccharide with and without the application of ultrasound, will be evaluated as well as the rheological behavior of emulsions of O / W prepared with different combinations of protein-polysaccharide as a function of the amount of oil added, the application of ultrasound and heating / cooling ramps. (AU)


Eichhornia azurea (Sw.) Kunth is an aquatic macrophyte frequently observed in lentic systems that can be colonized with a very rich and abundant macroinvertebrates community. This is because of the habitat complexity observed in its root's morphology and architecture which can be affected by seasonal variation of environmental factors of the lake. Thus, two questions can be considered: 1) There is a difference on the composition, taxa richness and abundance of macroinvertebrate community according of E. azurea rhizome and roots development stage? 2) Besides to plant's phenology, environmental variables and study period can be influence the colonization? The present project aims to answer these questions, considering the complexity levels of roots that the plants present according to its development, to the location and position of roots (from pelagic zone ’ to fixation point on littoral zone) and, to seasonal influence. The selected environment to answer these two questions is the Lake Barbosa, a marginal lake to Paranapanema River near its mouth site into Jurumirim reservoir. Quarterly samplings (from April, 2013 to January, 2014) will be made at least three different E. azurea stands. In each stand, five samples will be collect in a sequence from apical part of the floating plant to the site of fixing of macrophyte in the sediment, beginning with the 2th visible root system of E. azurea. In each sampling of the temporal scale, macroinvertebrate community attributes (composition, taxa richness and abundance) will be determine in each plant and stand (in this case the five samples of root system distributed by the rhizome); the complexity level of roots system will be measured and, the relationships with environmental variables will be assessed. (AU)


Microencapsulation, in the food industry, is a process in which one or more ingredients or additives are coated with an edible capsule extremely small. This is an innovative technology that has been successfully used in cosmetics, pharmaceutical and food industries. This technique can troubleshoot limitations on the use of food ingredients, such as natural pigments which are sensitive to light, heat, oxygen and pH. The aim of this work is to investigate the microencapsulation process by ionic gelation associated with the electrostatic interaction of colorants extracted from buriti pulp. For the ionic gelation step are evaluated two alternatives of biopolymers: alginate and pectin esterification amidated low, both being gelled in the presence of calcium ions. Then, the microcapsules produced are coated by electrostatic interaction with whey protein (WPC). The conditions for the adsorption of proteins on the surface of particles of alginate or pectin are defined based on the analysis of free charge total protein and polysaccharides solutions, which will allow the definition of pH and relative amount of polysaccharide/protein be used for the production of microparticles. The particles are evaluated with respect to morphology, size distribution, breaking conditions, stable to light and temperature and oxidative stability of microencapsulated corant. Will also be assessed the best storage conditions by determining the water sorption behavior of the microcapsules. (AU)


Phenology is the study of the occurrence of recurrent biological events in a given species or group of species and their relationship to biotic and abiotic factors. Phenological studies have been conducted to improve the understanding of ecosystem dynamics. In the context of current climate change, phenology has gained importance as a tool for monitoring and detect these changes, and as an important indicator, since changes in phenology have far-reaching consequences for ecological systems. However, the lack of standardization of methods to carry out the phenological research hampers accurate comparisons among studies and their interpretation. Phenological cycles of tropical plants are complex, and many irregular patterns are difficult to recognize. Therefore, it is crucial to conduct studies that address the methos to collect and analyse phenological data. The present study aims to investigate how the sample size and frequency of observations affect the definition of seasonal patterns, the relationship with climatic factors and their interpretation in plant phenology. We analyze the phenological patterns of three species of trees planted on the campus of UNESP, Rio Claro, SP, for changes in vegetative and reproductive phenology over eight years. Observations are weekly and we phenological evaluatinon takes into account the intensity index Fournier and activity index or percentage of individuals. The analysis will be made using correlation tests, regression and circular statistics. (AU)


For Samuel Beckett, the attention given to vocal performance of performers who acted in his plays was fundamental to the completeness his dramaturgical project. Beckett directed some of his plays showing constant concern for how their words would be emitted on stage. However, for him, clear and logical understanding of what his characters speak was not more important than the relationship between the sounds of words, silences and images on stage. The voice and the speech are plastic elements of composition of Beckett's scene as important as the others, composing a rigorous structure of activity, both corporal and vocal, which submits his interpreters to extreme experiences in their performances. The goal of this research is to investigate how Brazilian performers prepared themselves vocally to play Beckett's short texts. It is based on instances raised from the analysis of his theatrical work, starting from concepts, as the "performative voice" that seek to elucidate the vocality in his theater. Ten artists (directors, actors and actresses) with acknowledged experience in theater for at least ten years and who have professionally staged Samuel Beckett's play in the period from 1980 to 2012 in Brazil are being interviewed. The content of the interviews will be analyzed, Analysis Content's, a qualitative approach looking to establish from the responses, categories/topics witch characteristics be according to the theoretical references previously proposed. (AU)


This study of qualitative nature aims to investigate the possible interferences of animical living experiences on subjective perception of quality of life, in comparison to the public servants on scope of health and education. The study is developed through bibliographical and exploratory research. As an instrument for data collection of exploratory research is used the WHOQOL-Bref, applied through biphasic way before and after experiences with animical living as well as an open questionnaire with questions about the thematic involved. A purpositive sample of the study is made up by public servants, actives in the administrative sector of Unified Health System of a State University. The study is developed in three stages: the first on the report of the fellowship which was performed by data collection pre and post-experiences with animical living activities with public servants that work in the health field and with analysis of pre-experience results. Aiming to broaden the understanding about the quality of life perception for public servants of different segments. The second stage is related to the project of expansion of the fellowship being proposed the data analysis post-experiences with health servants, as well as the data collection pre and post- experiences with animical living activities with public servants who work in the administrative sector of a University. In the third and final stage, still in the context of the project of extension of the fellowship, a comparative study will be performed about the results obtained prior to the two stages. The data obtained through the instruments will be analyzed based on technical analysis of thematic content and may subsidize new reflections in the area. (AU)


The process of transcription by RNA polymerase (RNAP) is responsible for gene expression and metabolism control, and consequently, for individual development. The transcription is divided into three principal parts: initiation, elongation and termination. Several methods were utilized to study these processes, like atomic-force microscopy, single-molecule fluorescence and optical traps. These experiments show the complexity of the transcription process and, thus, models were proposed to explain this phenomenon and simulate the transcription. However, recent experiments exhibit an interesting transcription behavior in ribosomal sequences of Escherichia coli (E. coli) in the presence of high concentration of RNAP, which differ from the model predictions. The presence of anti-termination complexes and multiple enzymes increase the activity ratio and velocity of transcription. Although in silico models are available they consider a constant rate or disconsider RNAP interactions. In this project we propose the simulation of a stochastic kinetic sequence dependent model for RNAP movement in the template of ribosomal DNA of E. coli, that considers molecular interaction. The model will be validated through comparison with experimental results. (AU)


This research Project included in a cooperative action among the IQ-UNESP, the Depto de Física (USP, campus de São Carlos), the Depto de Química da FFCLRP-USP (campus de Ribeirão Preto) and the Depto. de Química do IST-UTL (Lisboa, Portugal) aims the preparation and characterization of nanoparticulate systrems containing lanthanide ions. The optical properties will be explored towards the energy transfer processe between active ions. Different niobate based systems willl be studied in order to optimize the sensitization of Yb3+ emission in the region of 1000nm through down conversion processes. In a second step developed materials will be tested on comercial photovoltaic silicon cells in order to well harvest the high energy (>2.6eV) of the sun light spectrum, no utilized by the Si cells. (AU)

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