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Influence of iontophoresis and ultrasound on the release of drugs from dendrimeric liquid crystals

Grant number: 17/05930-7
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): June 01, 2017
Effective date (End): May 31, 2019
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Renata Fonseca Vianna Lopez
Grantee:
Instituição-sede : Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto, SP, Brazil
Associated research grant:14/22451-7 - Sustained drug delivery systems targeting the epithelial tissue, AP.TEM

Abstract

Topical treatment has been studied as a promising alternative for skin cancer therapy. Our research group has evaluated ways to increase the skin penetration of chemotherapeutic drugs so that they are able to reach deeper layers of the skin. It is known that techniques such as iontophoresis and ultrasound promote the skin penetration of both small and macromolecules. However, both techniques involve the formation of regions of Located Transport (LTR), which restrict the effectiveness of these techniques. In recent studies we observed that iontophoresis of dispersions containing dendrimeric nanoparticles as carriers of drugs was able to increase the topic transport into the skin. Some studies reported in the literature have used dendrimers for the development of thermotropic ionic liquid crystals. Thermotropic liquid crystals are intermediate phases between the solid and liquid phases of a substance, whose degree of molecular organization responds to changes in temperature and can respond to application of electric current and ultrasound, changing characteristics such as viscosity, conductivity and molecular relaxation. These characteristics could be used to benefit the permeation of drugs associated with iontophoresis and ultrasound, but have never been studied for this purpose. Thus, this project proposes to develop liquid crystal dendrimer formulations and evaluate their influence on the efficiency of iontophoresis and ultrasound as cutaneous absorption promoters of a monoclonal antibody, cetuximab. (AU)