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INCT 2014: National Institute of Science and Technology in Bioanalysis

Grant number: 14/50867-3
Support type:Research Projects - Thematic Grants
Duration: July 01, 2017 - June 30, 2023
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Cooperation agreement: CNPq - INCTs
Principal Investigator:Lauro Tatsuo Kubota
Grantee:Lauro Tatsuo Kubota
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas, SP, Brazil
Co-Principal Investigators:Auro Atsushi Tanaka ; Emanuel Carrilho ; Érico Marlon de Moraes Flores ; Lucio Angnes ; Marco Aurelio Zezzi Arruda ; MARÍLIA OLIVEIRA FONSEC GOULART ; Ronei Jesus Poppi ; Wendel Andrade Alves
Associated grant(s):17/26037-9 - Multi-user equipment approved in grant 14/50867-3: Scanning Electrochemical Microscopy and optical surface profiler, AP.EMU
Associated scholarship(s):18/03956-1 - Development and application of the novelty SPME device - coated blade spray, BP.PD
16/20547-2 - Characterization of the metabolome of anti-phytopatogen microorganisms by multidimensional gas chromatography and simple / tandem mass spectrometry (GC×GC-QMS and GC×GC-MS/MS), BP.DR


Analytical Chemistry, in the last years, has directed great efforts to the development of analytical methods for the analysis of samples and/or analytes of biological interest. The huge impact of the researches in this area provided a race towards the development of methods for the chemical analyses of substances of live organisms. With the engagement of analytical chemists in the development of methods for biological, biochemical and clinical purposes, not only a very big increase in the works in this area was verified, but also the emergence of research groups working specifically in the area of analyses of biological samples. The importance of these works led to the birth of the area of bioanalytics, being a great focus of actuation of analytical chemists. In the country, however, bioanalytics is very incipient and some researchers work with different analytical techniques to develop methods of bioanalysis, despite the fact that this area is of great strategic importance to the country. Even in front of this strategic importance, little has been done so as to develop analytical tools for the diagnosis of diseases, disorders, pharmacological action, among others. In was in this context that the National Institute of Science and Technology of Bioanalytics - INCTBio was created in 2009, with the goal of carrying out coordinated works with exchange of information between the researchers in different areas of actuation so as to seek for the consolidation of the area in the country. Among the concerns in the creation of the institute of bioanalytics, there was the formation of human resources and the diffusion of the area in society, as well as the transfer to society of the benefits provided by the development of analytical tools for the improvement of life quality, be it in the speciation of biological molecules of interest, in the development of analytical methods that can provide fast and mostly real-time results, or in the use of mathematical tools when it is necessary to interpret complex data, among others described in the detailing of the lines of research inserted in this proposal. During the last 05 years of existence of the INCTBio, the group counted with the partnership and collaboration of 39 researchers from 22 different institutions. Initially, we sought to select the best researchers to be part of the group, taking into consideration the regional issue, institutions and young researchers. One of the goals of the group was the consolidation and strengthening of young researchers and recent institutions without great tradition in research. Today, these groups have been consolidated and many of them have become reference in bioanalytics in the country, impelling the development of science in regions that were forgotten in the scientific scenario. The development of projects inside the INCTBio adjusted to the emergent necessities, focused on the strategic interest of the country, as it was emphasized by the advisor of the fourth report: “Faced by the fact that the group of the project includes the majority of the exponents of the Instrumental Analytical Chemistry of the country, both in the employment of techniques and equipment of latest generation, and in the development of devices and patentable methods for clinical analyses of national interest, the fact that the fourth report proves important advances in the original project and points to new researches in the more biological area (metabolomics) and discoveries resulting from the work already realized and published, does not surprise”. The scientific production of the Institute in these 05 years was extremely intense, being “admirable” in the advisor’s words. In total, 563 articles were published (without considering the articles of 2014-2015), and of these, 66 were in national journals and 497 in international ones. It is worth emphasizing that the number of published articles followed an ascendant, year to year, presenting an increase superior to 400%, going from 46 articles in 2009 to 200 articles in 2013, having an average impact factor of 3.1 of all the publications. The formation of human resources was one of the main points of interest of the Institute, permitting bioanalytics to become a solid and strong area in the country, guaranteeing the continuity of the scientific development in this strategic area, and once more, citing the advisor of the fourth report: “Without doubt, the scientific production of the group of researchers of the INCTBio is admirable. In this report, the publication of 259 articles in journals of medium and high impact in the areas of Analytical Chemistry, Materials and Biotechnology, the requirement of 05 patents, nearly 200 participations in national and international congresses, 09 book chapters and 12 awards are pointed. 04 projects were established together with companies and the covenant with the INC-DF”. Apart from the productions already mentioned, the INCTBio contributed with 10 book chapters, 08 patents and products were required and 02 were licensed, and it received 12 awards. In the period from 2009 to 2013, the INCTBio formed 110 specialists in the area of bioanalytics, being 67 masters and 43 doctors, and apart from these, it counted with the collaboration of approximately 50 post-doctoral students and contributed to the academic formation of 112 Scientific Initiation students, attracting more and more graduate students to this theme. (AU)

Scientific publications (15)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE OLIVEIRA NEVES, LEANDRA NATALIA; MARQUES, RAFAEL; FONSECA DA SILVA, PAULO HENRIQUE; LEAL DE OLIVEIRA, MARCONE AUGUSTO. Lactulose determination in UHT milk by CZE-UV with indirect detection. Food Chemistry, v. 258, p. 337-342, AUG 30 2018. Web of Science Citations: 0.
CASARIN, JULIANA; GONCALVES JUNIOR, AFFONSO CELSO; SEGATELLI, MARIANA GAVA; TEIXEIRA TARLEY, CESAR RICARDO. Insight into the performance of molecularly imprinted poly(methacrylic acid) and polyvinylimidazole for extraction of imazethapyr in aqueous medium. CHEMICAL ENGINEERING JOURNAL, v. 343, p. 583-596, JUL 1 2018. Web of Science Citations: 0.
DA COSTA, PAULO VINICIUS F.; DA SILVA, REJANE MARIA P.; SUFFREDINI, HUGO B.; ALVES, WENDEL A. Poly-L-Arginine-Modified Boron-Doped Diamond and Glassy Carbon Electrodes for Terbutaline Sulfate Detection. Journal of Nanoscience and Nanotechnology, v. 18, n. 7, p. 4551-4558, JUL 2018. Web of Science Citations: 0.
KUCEKI, MICHELE; DE OLIVEIRA, FERNANDA MIDORI; SEGATELLI, MARIANA GAVA; LOMBELLO COELHO, MALENA KARLA; PEREIRA, ARNALDO CESAR; DA ROCHA, LUANA RIANNE; MENDONCA, JHESSICA DE CASSIA; TEIXEIRA TARLEY, CESAR RICARDO. Selective and sensitive voltammetric determination of folic acid using graphite/restricted access molecularly imprinted poly(methacrylic acid)/SiO2 composite. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, v. 818, p. 223-230, JUN 1 2018. Web of Science Citations: 0.
TARLEY, CESAR R. T.; SCHEEL, GUILHERME L.; RIBEIRO, EMERSON S.; ZAPPIELO, CAROLINE D.; SUQUILA, FABIO A. C. Synthesis of Chelating Agent Free-Solid Phase Extractor (CAF-SPE) Based on New SiO2/Al2O3/SnO2 Ternary Oxide and Application for Online Preconcentration of Pb2+ Coupled with FAAS. Journal of the Brazilian Chemical Society, v. 29, n. 6, p. 1225-1236, JUN 2018. Web of Science Citations: 0.
BARRAGAN, JOSE T. C.; DA SILVA, EVERSON T. S. G.; DE MORAES, ANA C. M.; KUBOTA, LAURO T. A novel approach for electroanalytical determinations employing discharge of pseudocapacitor by electroactive species. Analytica Chimica Acta, v. 1006, p. 1-9, MAY 2 2018. Web of Science Citations: 1.
FELIX, FABIANA S.; ANGNES, LUCIO. Electrochemical immunosensors - A powerful tool for analytical applications. BIOSENSORS & BIOELECTRONICS, v. 102, p. 470-478, APR 15 2018. Web of Science Citations: 5.
SCHEEL, GUILHERME LUIZ; DE OLIVEIRA, FERNANDA MIDORI; GONCALVES DE OLIVEIRA, LEANDRO LUAN; MEDEIROS, ROBERTA ANTIGO; NASCENTES, CLESIA CRISTINA; TEIXEIRA TARLEY, CESAR RICARDO. Feasibility study of ethylone determination in seized samples using boron-doped diamond electrode associated with solid phase extraction. SENSORS AND ACTUATORS B-CHEMICAL, v. 259, p. 1113-1122, APR 15 2018. Web of Science Citations: 1.
OLIVEIRA, M. A. L.; CHELLINI, P. R.; AMORIM, T. L. Simultaneous determination of rifampicin, isoniazid, pyrazinamide and ethambutol in fixed-dose combination antituberculosis pharmaceutical formulations: a review. ANALYTICAL METHODS, v. 10, n. 10, p. 1103-1116, MAR 14 2018. Web of Science Citations: 0.
BARRAGAN, JOSE T. C.; KOGIKOSKI, JR., SERGIO; DA SILVA, EVERSON T. S. G.; KUBOTA, LAURO T. Insight into the Electro-Oxidation Mechanism of Glucose and Other Carbohydrates by CuO-Based Electrodes. Analytical Chemistry, v. 90, n. 5, p. 3357-3365, MAR 6 2018. Web of Science Citations: 0.
MARTINI, WILLIAM S.; PORTO, BRENDA L. S.; DE OLIVEIRA, MARCONE A. L.; SANT'ANA, ANTONIO C. Comparative Study of the Lipid Profiles of Oils from Kernels of Peanut, Babassu, Coconut, Castor and Grape by GC-FID and Raman Spectroscopy. Journal of the Brazilian Chemical Society, v. 29, n. 2, p. 390-397, FEB 2018. Web of Science Citations: 0.
ROCHA, DIEGO P.; CARDOSO, RAFAEL M.; MENDONCA, DIANDERSON M. H.; RICHTER, EDUARDO M.; DA SILVA, SIDNEI G.; BATISTA, ALEX D.; MUNOZ, RODRIGO A. A. Solenoid Micro-pumps: A New Tool for Sample Introduction in Batch Injection Analysis Systems with Electrochemical Detection. Electroanalysis, v. 30, n. 1, p. 180-186, JAN 2018. Web of Science Citations: 0.
SQUISSATO, ANDRE L.; ROCHA, DIEGO P.; ALMEIDA, EDUARDO S.; RICHTER, EDUARDO M.; MUNOZ, RODRIGO A. A. Stripping Voltammetric Determination of Mercury in Fish Oil Capsules Using a Screen-printed Gold Electrode. Electroanalysis, v. 30, n. 1, p. 20-23, JAN 2018. Web of Science Citations: 0.
ARAUJO, FAUSTO M.; SANTOS, MELLINA D. R.; DE OLIVEIRA, MARCONE A. L.; MATOS, RENATO C.; MATOS, MARIA. A. C. Box-Behnken design applied to optimize the ultrasound-assisted extraction of petroleum biomarkers in river sediment samples using green analytical chemistry. ANALYTICAL METHODS, v. 9, n. 40, p. 5859-5867, OCT 28 2017. Web of Science Citations: 0.
SOUZA, MARCIA I.; PRIETO, TATIANA; RODRIGUES, TIAGO; FERREIRA, FABIO F.; NASCIMENTO, FRANCISCO B.; RIBEIRO, ANDERSON O.; SILVA, EMERSON R.; GIUNTINI, FRANCESCA; ALVES, WENDEL A. Conjugation with L, L-diphenylalanine Self-Assemblies Enhances In Vitro Antitumor Activity of Phthalocyanine Photosensitizer. SCIENTIFIC REPORTS, v. 7, OCT 13 2017. Web of Science Citations: 1.

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