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Protein quality control in dysfunctional/atrophic skeletal muscle: role of b2-adrenoceptor

Grant number: 15/20783-5
Support type:Regular Research Grants
Duration: April 01, 2016 - March 31, 2018
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Julio Cesar Batista Ferreira
Grantee:Julio Cesar Batista Ferreira
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo, SP, Brazil
Assoc. researchers:Marcelo Alves da Silva Mori
Associated grant(s):15/50429-9 - Protein Quality Control in dysfunctional/atrophic skeletal muscle: roke of B2 adrenoceptor, AP.R

Abstract

The cellular protein quality control (PQC) machinery detects repairs and disposes cytotoxic proteins through different proteolytic systems (i.e. ubiquitin-proteasome system and autophagy). We recently demonstrated that improving PQC protects against cardiac diseases. Here, we are going to characterize the PQC profile as well as the benefits of sustained ²2-adrenoceptor activation, a positive PQC modulator, during skeletal muscle degeneration in a rat model of sciatic nerve constriction (SNC). (AU)