Abstract

Dengue is an infectious viral disease and one of the most important arboviruses in the world. The virus is maintained in a cycle of urban transmission man - mosquitoes - man: The vector control is a prevention strategies most commonly used. Often the Dengue studies regard only reported cases without grouping data relating to past epidemics. Through a prospective cohort study lasting from five years we will estimate the principal measures taken to disease frequency occurring in a particular neighborhood of the city of São José do Rio Preto, in São Paulo, Brazil. The studies will be relating of the Population that will participate, through by epidemiological and serological lifting, identifying risk factors and evaluation of the knowledge and practices of the population; will be relating of the Virus X Host interaction, by symptoms observations and disease evolution, the presence of antibodies and their classes, presence of specific polymorphisms inducing severe disease and other factors related to this induction; relating of the Virus, identifying serotype and genetic characteristics and its ability to inhibit the production of interferon; and relating of the Vector, through the capture and identification of mosquitoes, the knowledge of their behavior, the correlation of weather data with the presence of the vector and risk factors related to the presence of mosquitoes. These studies involve Laboratories and Research Center in Dengue throughout Brazil and collaborators of the Research in the U.S. The reference center and interconnection shall be Research Virology Lab in Faculdade de Medicina de São José do Rio Preto/FAMERP who receive and distribute all samples, collected in partnership with the prefecture and health services in the municipality. (AU)