Epidemiological study of dengue (serotypes1-4) in a cohort of São José do Rio Preto, São Paulo, Brazil, during 2014-2018

• Grant number: 13/21719-3
• Support type: Research Projects - Thematic Grants
• Duration: June 01, 2015 - May 31, 2020
• Field of knowledge: Biological Sciences - Microbiology
• Principal Investigator: Maurício Lacerda Nogueira
• Grantee: Maurício Lacerda Nogueira
• Home Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico, Ciência e Tecnologia (São Paulo - Estado). São José do Rio Preto, SP, Brazil
• Co-Principal Investigators: Francisco Chiaravalloti Neto
• Assoc. researchers: Erna Geessien Kroon ; Francisco Chiaravalloti Neto ; João Pessoa Araújo Junior ; Margareth Regina Dibo ; Mauro Martins Teixeira
• Associated scholarship(s): 15/14313-6 - Genetic and biological characterization of dengue virus, Zika virus and Chikungunya virusisolated in a prospective cohort in SJ Rio Preto, SP, BP.DR; 17/21688-1 - Retrospective cohort of pregnant exposed to the Zika virus in São José do Rio Preto in 2016, BP.IC; 17/10297-1 - Identification of risk areas for arboviruses using traps for adults of Aedes aegypti and Aedes albopictus and remote sensing images, BP.PD; + associated scholarships 17/09671-6 - Epidemiological study of dengue (serotypes1-4), Zika e Chikungunya in a cohort of São José do Rio Preto, São Paulo, Brazil: analysis of the first wave results, BE.PQ; 16/16344-9 - Clinical and neuropsychiatric caracterization of pacients with dengue diagnosis after acute infection in São José do Rio Preto, during the year 2016, BP.IC; 15/12310-0 - Clinical and laboratory characterization of patients diagnosed with dengue, Chikungunya and ZIKA among cohort patients with suspected symptomatology in São José do Rio Preto, in 2016, BP.IC; 15/12295-0 - Diagnostic of Brazilian and emergent arboviruses in patients and mosquitoes from two distinct regions in Brazil, BP.PD; 15/22750-7 - Assessment of viral and epidemiological fitness differences between two lineages of Dengue serotype 1 co-circulating during 2010-2012 in São José do Rio Preto, SP, BP.DD - associated scholarships

Abstract

Dengue is an infectious viral disease and one of the most important arboviruses in the world. The virus is maintained in a cycle of urban transmission man - mosquitoes - man: The vector control is a prevention strategies most commonly used. Often the Dengue studies regard only reported cases without grouping data relating to past epidemics. Through a prospective cohort study lasting from five years we will estimate the principal measures taken to disease frequency occurring in a particular neighborhood of the city of São José do Rio Preto, in São Paulo, Brazil. The studies will be relating of the Population that will participate, through by epidemiological and serological lifting, identifying risk factors and evaluation of the knowledge and practices of the population; will be relating of the Virus X Host interaction, by symptoms observations and disease evolution, the presence of antibodies and their classes, presence of specific polymorphisms inducing severe disease and other factors related to this induction; relating of the Virus, identifying serotype and genetic characteristics and its ability to inhibit the production of interferon; and relating of the Vector, through the capture and identification of mosquitoes, the knowledge of their behavior, the correlation of weather data with the presence of the vector and risk factors related to the presence of mosquitoes. These studies involve Laboratories and Research Center in Dengue throughout Brazil and collaborators of the Research in the U.S. The reference center and interconnection shall be Research Virology Lab in Faculdade de Medicina de São José do Rio Preto/FAMERP who receive and distribute all samples, collected in partnership with the prefecture and health services in the municipality. (AU)

Scientific publications

(21)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NOGUEIRA, M. L.; NERY JUNIOR, N. R. R.; ESTOFOLETE, C. F.; BERNARDES TERZIAN, A. C.; GUIMARAES, G. F.; ZINI, N.; ALVES DA SILVA, R.; DUTRA SILVA, G. C.; JUNQUEIRA FRANCO, L. C.; RAHAL, P.; BITTAR, C.; CARNEIRO, B.; VASCONCELOS, P. F. C.; FREITAS HENRIQUES, D.; BARBOSA, D. M. U.; LOPES ROMBOLA, P.; DE GRANDE, L.; NEGRI REIS, A. F.; PALOMARES, S. A.; WAKAI CATELAN, M.; CRUZ, L. E. A. A.; NECCHI, S. H.; MENDONCA, R. C. V.; PENHA DOS SANTOS, I. N.; ALAVARSE CARON, S. B.; COSTA, F.; BOZZA, F. A.; SOARES DE SOUZA, A.; BRANDAO DE MATTOS, C. C.; DE MATTOS, L. C.; VASILAKIS, N.; OLIANI, A. H.; VAZ OLIANI, D. C. M.; KO, A. I. Adverse birth outcomes associated with Zika virus exposure during pregnancy in Sao Jose do Rio Preto, Brazil. Clinical Microbiology and Infection, v. 24, n. 6, p. 646-652, JUN 2018. Web of Science Citations: 1.

PEREIRA PARRA, MAISA CARLA; FAVARO, ELIANE APARECIDA; DIBO, MARGARETH REGINA; MONDINI, ADRIANO; EIRAS, ALVARO EDUARDO; KROON, ERNA GEESSIEN; TEIXEIRA, MAURO MARTINS; NOGUEIRA, MAURICIO LACERDA; CHIARAVALLOTI-NETO, FRANCISCO. Using adult & IT;Aedes aegypti & IT; females to predict areas at risk for dengue transmission: A spatial case-control study. Acta Tropica, v. 182, p. 43-53, JUN 2018. Web of Science Citations: 0.

Zika detection: comparison of methodologies. Brazilian Journal of Microbiology, v. 49, n. 1, p. -, Mar. 2018.

DA SILVA, NATAL SANTOS; UNDURRAGA, EDUARDO A.; DA SILVA FERREIRA, ELIS REGINA; ESTOFOLETE, CASSIA FERNANDA; NOGUEIRA, MAURICIO LACERDA. Clinical, laboratory, and demographic determinants of hospitalization due to dengue in 7613 patients: A retrospective study based on hierarchical models. Acta Tropica, v. 177, p. 25-31, JAN 2018. Web of Science Citations: 0.

COLOMBO, TATIANA ELIAS; BERNARDES TERZIAN, ANA CAROLINA; ARAUJO JUNIOR, JOAO PESSOA; PARREIRA, RICARDO; SOTELLO CABRER, ELIANA MARCIA; PENHA DOS SANTOS, IZALCO NUREMBERG; NEGRI REIS, ANDREIA FRANCESLI; COSTA, FABIANA RODRIGUES; ARAO ANTONIO CRUZ, LILIAN ELISA; ROMBOLA, PATRICIA LOPES; NOGUEIRA, MAURICIO LACERDA. Zika detection: comparison of methodologies. Brazilian Journal of Microbiology, v. 49, n. 1, p. 144-147, JAN-MAR 2018. Web of Science Citations: 0.

COLOMBO, TATIANA ELIAS; ESTOFOLETE, CASSIA FERNANDA; NEGRI REIS, ANDREIA FRANCESLI; DA SILVA, NATAL SANTOS; AGUIAR, MORGANA LIMA; SOTELLO CABRERA, ELIANA MARCIA; PENHA DOS SANTOS, IZALCO NUREMBERG; COSTA, FABIANA RODRIGUES; ARAO ANTONIO CRUZ, LILIAN ELISA; ROMBOLA, PATRICIA LOPES; BERNARDES TERZIAN, ANA CAROLINA; NOGUEIRA, MAURICIO LACERDA. Clinical, laboratory and virological data from suspected ZIKV patients in an endemic arbovirus area. Journal of Clinical Virology, v. 96, p. 20-25, NOV 2017. Web of Science Citations: 2.

TERZIAN, ANA CAROLINA B.; ESTOFOLETE, CASSIA FERNANDA; DA SILVA, RAFAEL ALVES; MOS VAZ-OLIANI, DENISE CRISTINA; OLIANI, ANTONIO HELIO; BRANDAO DE MATTOS, CINARA CASSIA; DE MATTOS, LUIZ CARLOS; RAHAL, PAULA; NOGUEIRA, MAURICIO L. Long-Term Viruria in Zika Virus-Infected Pregnant Women, Brazil, 2016. Emerging Infectious Diseases, v. 23, n. 11, p. 1891-1893, NOV 2017. Web of Science Citations: 1.

BERNARDES TERZIAN, ANA CAROLINA; SCHANOSKI, ALESSANDRA SOARES; DE OLIVEIRA MOTA, MINH' TASSO; DA SILVA, RAFAEL ALVES; ESTOFOLETE, CASSIA FERNANDA; COLOMBO, TATIANA ELIAS; RAHAL, PAULA; HANLEY, KATHRYN A.; VASILAKIS, NIKOS; KALIL, JORGE; NOGUEIRAL, MAURICIO LACERDA. Viral Load and Cytokine Response Profile Does Not Support Antibody-Dependent Enhancement in Dengue-Primed Zika Virus-Infected Patients. Clinical Infectious Diseases, v. 65, n. 8, p. 1260-1265, OCT 15 2017. Web of Science Citations: 9.

BOSCH, IRENE; DE PUIG, HELENA; HILEY, MEGAN; CARRE-CAMPS, MARC; PERDOMO-CELIS, FEDERICO; NARVAEZ, CARLOS F.; SALGADO, DORIS M.; SENTHOOR, DEWAHAR; O'GRADY, MADELINE; PHILLIPS, ELIZABETH; DURBIN, ANN; FANDOS, DIANA; MIYAZAKI, HIKARU; YEN, CHUN-WAN; GELVEZ-RAMIREZ, MARGARITA; WARKE, RAJAS V.; RIBEIRO, LUCAS S.; TEIXEIRA, MAURO M.; ALMEIDA, ROQUE P.; MUNOZ-MEDINA, JOSE E.; LUDERT, JUAN E.; NOGUEIRA, MAURICIO L.; COLOMBO, TATIANA E.; TERZIAN, ANA C. B.; BOZZA, PATRICIA T.; CALHEIROS, ANDREA S.; VIEIRA, YASMINE R.; BARBOSA-LIMA, GISELLE; VIZZONI, ALEXANDRE; CERBINO-NETO, JOSE; BOZZA, FERNANDO A.; SOUZA, THIAGO M. L.; TRUGILHO, MONIQUE R. O.; DE FILIPPIS, ANA M. B.; DE SEQUEIRA, PATRICIA C.; MARQUES, ERNESTO T. A.; MAGALHAES, TEREZA; DIAZ, FRANCISCO J.; RESTREPO, BERTA N.; MARIN, KATERINE; MATTAR, SALIM; OLSON, DANIEL; ASTURIAS, EDWIN J.; LUCERA, MARK; SINGLA, MOHIT; MEDIGESHI, GURUPRASAD R.; DE BOSCH, NORMA; TAM, JUSTINA; GOMEZ-MARQUEZ, JOSE; CLAVET, CHARLES; VILLAR, LUIS; HAMAD-SCHIFFERLI, KIMBERLY; GEHRKE, LEE. Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum. Science Translational Medicine, v. 9, n. 409 SEP 27 2017. Web of Science Citations: 7.

REN, PING; ORTIZ, DANIEL A.; TERZIAN, ANA C. B.; COLOMBO, TATIANA E.; NOGUEIRA, MAURICIO L.; VASILAKIS, NIKOS; LOEFFELHOLZ, MICHAEL J. Evaluation of Aptima Zika Virus Assay. Journal of Clinical Microbiology, v. 55, n. 7, p. 2198-2203, JUL 2017. Web of Science Citations: 6.

SILVA, M. L. C. R.; AUGUSTE, A. J.; TERZIAN, A. C. B.; VEDOVELLO, D.; RIET-CORREA, F.; MACARIO, V. M. K.; MOURAO, M. P. G.; ULLMANN, L. S.; ARAUJO, JR., J. P.; WEAVER, S. C.; NOGUEIRA, M. L. Isolation and Characterization of Madariaga Virus from a Horse in Paraiba State, Brazil. TRANSBOUNDARY AND EMERGING DISEASES, v. 64, n. 3, p. 990-993, JUN 2017. Web of Science Citations: 2.

MARQUES, RAFAEL ELIAS; DEL SARTO, JULIANA L.; ROCHA, REBECA P. F.; GOMES, GIOVANNI F.; CRAMER, ALLYSSON; RACHID, MILENE A.; SOUZA, DANIELLE G.; NOGUEIRA, MAURICIO L.; TEIXEIRA, MAURO M. Development of a model of Saint Louis encephalitis infection and disease in mice. JOURNAL OF NEUROINFLAMMATION, v. 14, MAR 22 2017. Web of Science Citations: 1.

TUKASAN, CAROLINE; FURLAN, NATHALIA BARBOSA; ESTOFOLETE, CASSIA FERNANDA; NOGUEIRA, MAURICIO LACERDA; DA SILVA, NATAL SANTOS. Evaluation of the importance of fever with respect to dengue prognosis according to the 2009 WHO classification: a retrospective study. BMC INFECTIOUS DISEASES, v. 17, JAN 4 2017. Web of Science Citations: 1.

DE SOUZA, ANTONIO SOARES; DIAS, CRISTIANE MORAES; BRAOJOS BRAGA, FERNANDA DEL CAMPO; BERNARDES TERZIAN, ANA CAROLINA; ESTOFOLETE, CASSIA FERNANDA; OLIANI, ANTONIO HELIO; OLIVEIRA, GUSTAVO HENRIQUE; BRANDAO DE MATTOS, CINARA CASSIA; DE MATTOS, LUIZ CARLOS; NOGUEIRA, MAURICIO LACERDA; MOS VAZ-OLIANI, DENISE CRISTINA. Fetal Infection by Zika Virus in the Third Trimester: Report of 2 Cases. Clinical Infectious Diseases, v. 63, n. 12, p. 1622-1625, DEC 15 2016. Web of Science Citations: 21.

FURLAN, NATHALIA BARBOSA; TUKASAN, CAROLINE; ESTOFOLETE, CASSIA FERNANDA; NOGUEIRA, MAURICIO LACERDA; DA SILVA, NATAL SANTOS. Low sensitivity of the tourniquet test for differential diagnosis of dengue: an analysis of 28,000 trials in patients. BMC INFECTIOUS DISEASES, v. 16, NOV 3 2016. Web of Science Citations: 1.

BITTAR, CINTIA; MACHADO, DAIANE CRISTINA; VEDOVELLO, DANILA; ULLMANN, LEILA SABRINA; RAHAL, PAULA; ARAUJO JUNIOR, JOAO PESSOA; NOGUEIRA, MAURICIO LACERDA. Genome sequencing and genetic characterization of Culex Flavirirus (CxFV) provides new information about its genotypes. VIROLOGY JOURNAL, v. 13, SEP 23 2016. Web of Science Citations: 0.

CARNEIRO, BRUNO M.; BATISTA, MARIANA N.; BRAGA, ANA CLAUDIA S.; NOGUEIRA, MAURICIO L.; RAHAL, PAULA. The green tea molecule EGCG inhibits Zika virus entry. VIROLOGY, v. 496, p. 215-218, SEP 2016. Web of Science Citations: 25.

ESTOFOLETE, CASSIA FERNANDA; OLIVEIRA MOTA, MANLIO TASSO; VEDOVELLO, DANILA; NUNES DE GONGORA, DELZI VINHA; MAIA, IRINEU LUIZ; NOGUEIRA, MAURICIO LACERDA. Mayaro fever in an HIV-infected patient suspected of having Chikungunya fever. Revista da Sociedade Brasileira de Medicina Tropical, v. 49, n. 5, p. 648-652, SEP-OCT 2016. Web of Science Citations: 1.

ESTOFOLETE, CASSIA FERNANDA; BERNARDES TERZIAN, ANA CAROLINA; PARREIRA, RICARDO; ESTEVES, AIDA; HARDMAN, LUCAS; GREQUE, GILMAR VALDIR; RAHAL, PAULA; NOGUEIRA, MAURICIO LACERDA. Clinical and laboratory profile of Zika virus infection in dengue suspected patients: A case series. Journal of Clinical Virology, v. 81, p. 25-30, AUG 2016. Web of Science Citations: 16.

DUTRA, KARINA ROCHA; DRUMOND, BETANIA PAIVA; DE REZENDE, IZABELA MAURICIO; NOGUEIRA, MAURICIO LACERDA; LOPES, DEBORA DE OLIVEIRA; CALZAVARA SILVA, CARLOS EDUARDO; SIQUEIRA FERREIRA, JAQUELINE MARIA; DOS SANTOS, LUCIANA LARA. Molecular surveillance of dengue in Minas Gerais provides insights on dengue virus 1 and 4 circulation in Brazil. Journal of Medical Virology, v. 89, n. 6, p. 966-973, JUN 2016. Web of Science Citations: 0.

DE OLIVEIRA MOTA, MANLIO TASSO; RIBEIRO, MILENE ROCHA; VEDOVELLO, DANILA; NOGUEIRA, MAURCIO LACERDA. Mayaro virus: a neglected arbovirus of the Americas. FUTURE VIROLOGY, v. 10, n. 9, p. 1109-1122, 2015. Web of Science Citations: 7.