Epidemiological study of dengue( serotypes1-4) in a cohort of São José do Rio Preto, São Paulo, Brazil, during 2014-2018

Grant number: 13/21719-3
Support type:Research Projects - Thematic Grants
Duration: June 01, 2015 - May 31, 2020
Field of knowledge:Biological Sciences - Microbiology
Principal Investigator:Maurício Lacerda Nogueira
Home Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico, Ciência e Tecnologia (São Paulo - Estado). São José do Rio Preto, SP, Brazil
Co-Principal Investigators:Francisco Chiaravalloti Neto
Assoc. researchers:João Pessoa Araújo Junior ; Margareth Regina Dibo ; Mauro Martins Teixeira ; Erna Geessien Kroon
Associated scholarship(s):16/16344-9 - Clinical and neuropsychiatric caracterization of pacients with dengue diagnosis after acute infection in São José do Rio Preto, during the year 2016, BP.IC
15/12310-0 - Clinical and laboratory characterization of patients diagnosed with dengue, Chikungunya and Zika among cohort patients with suspected symptomatology in São José do Rio Preto, in 2016, BP.IC
15/12295-0 - Diagnostic of Brazilian and emergent arboviruses in patients and mosquitoes from two distinct regions in Brazil, BP.PD
15/22750-7 - Assessment of viral and epidemiological fitness differences between two lineages of Dengue serotype 1 co-circulating during 2010-2012 in São José do Rio Preto, SP, BP.DD
Dengue is an infectious viral disease and one of the most important arboviruses in the world. The virus is maintained in a cycle of urban transmission man - mosquitoes - man: The vector control is a prevention strategies most commonly used. Often the Dengue studies regard only reported cases without grouping data relating to past epidemics. Through a prospective cohort study lasting from five years we will estimate the principal measures taken to disease frequency occurring in a particular neighborhood of the city of São José do Rio Preto, in São Paulo, Brazil. The studies will be relating of the Population that will participate, through by epidemiological and serological lifting, identifying risk factors and evaluation of the knowledge and practices of the population; will be relating of the Virus X Host interaction, by symptoms observations and disease evolution, the presence of antibodies and their classes, presence of specific polymorphisms inducing severe disease and other factors related to this induction; relating of the Virus, identifying serotype and genetic characteristics and its ability to inhibit the production of interferon; and relating of the Vector, through the capture and identification of mosquitoes, the knowledge of their behavior, the correlation of weather data with the presence of the vector and risk factors related to the presence of mosquitoes. These studies involve Laboratories and Research Center in Dengue throughout Brazil and collaborators of the Research in the U.S. The reference center and interconnection shall be Research Virology Lab in Faculdade de Medicina de São José do Rio Preto/FAMERP who receive and distribute all samples, collected in partnership with the prefecture and health services in the municipality. (AU)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TUKASAN, CAROLINE; FURLAN, NATHALIA BARBOSA; ESTOFOLETE, CASSIA FERNANDA; NOGUEIRA, MAURICIO LACERDA; DA SILVA, NATAL SANTOS. Evaluation of the importance of fever with respect to dengue prognosis according to the 2009 WHO classification: a retrospective study. BMC INFECTIOUS DISEASES, v. 17, JAN 4 2017. Web of Science Citations: 0.
FURLAN, NATHALIA BARBOSA; TUKASAN, CAROLINE; ESTOFOLETE, CASSIA FERNANDA; NOGUEIRA, MAURICIO LACERDA; DA SILVA, NATAL SANTOS. Low sensitivity of the tourniquet test for differential diagnosis of dengue: an analysis of 28,000 trials in patients. BMC INFECTIOUS DISEASES, v. 16, NOV 3 2016. Web of Science Citations: 0.
BITTAR, CINTIA; MACHADO, DAIANE CRISTINA; VEDOVELLO, DANILA; ULLMANN, LEILA SABRINA; RAHAL, PAULA; ARAUJO JUNIOR, JOAO PESSOA; NOGUEIRA, MAURICIO LACERDA. Genome sequencing and genetic characterization of Culex Flavirirus (CxFV) provides new information about its genotypes. VIROLOGY JOURNAL, v. 13, SEP 23 2016. Web of Science Citations: 0.
CARNEIRO, BRUNO M.; BATISTA, MARIANA N.; BRAGA, ANA CLAUDIA S.; NOGUEIRA, MAURICIO L.; RAHAL, PAULA. The green tea molecule EGCG inhibits Zika virus entry. VIROLOGY, v. 496, p. 215-218, SEP 2016. Web of Science Citations: 0.
ESTOFOLETE, CASSIA FERNANDA; BERNARDES TERZIAN, ANA CAROLINA; PARREIRA, RICARDO; ESTEVES, AIDA; HARDMAN, LUCAS; GREQUE, GILMAR VALDIR; RAHAL, PAULA; NOGUEIRA, MAURICIO LACERDA. Clinical and laboratory profile of Zika virus infection in dengue suspected patients: A case series. Journal of Clinical Virology, v. 81, p. 25-30, AUG 2016. Web of Science Citations: 2.
DE OLIVEIRA MOTA, MANLIO TASSO; RIBEIRO, MILENE ROCHA; VEDOVELLO, DANILA; NOGUEIRA, MAURCIO LACERDA. Mayaro virus: a neglected arbovirus of the Americas. FUTURE VIROLOGY, v. 10, n. 9, p. 1109-1122, 2015. Web of Science Citations: 1.
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