Search for potential antitumoral, antioxidant, antiinflammatory, antidiabetic, acetylcholinesterase and mieloperoxidase inhibitory natural compounds from Cerrado and Atlantic Forest

Principal Investigator:

Dulce Helena Siqueira Silva

Awardee:

Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara, SP, Brazil
Co-Principal Investigators:

Alberto José Cavalheiro

Field of knowledge:Physical Sciences and Mathematics - Chemistry
Support type:BIOTA-FAPESP Program - Thematic Grants
Grant number: 04/07932-7
Duration: March 01, 2005 - July 31, 2010
Associated grant(s):07/51452-8 - Rapid screening of antioxidant and antimalarial compounds from natural complex matrixes using HPLC-micro fraction analysis: application to crude extracts from chiococca ALBA, AR.EXT
Associated scholarship(s):07/50348-2 - Biomonitored phytochemical study of Casearia lasiophylla (Flacourtiaceae), BP.IC
06/60891-2 - Tracing of genotoxicity of antimutagenesis of semi-purified fractions extracted from Pterogyne nitens using the test of the micronucleus in Tradescantia pallida, BP.IC
06/60150-2 - Configurational analysis of styrylpyrones of species of Cryptocarya (Lauraceae), BP.IC
+ associated scholarships 06/60151-9 - Chromatographic profile of the metabolites of species of the Flacourtiaceae family: biomonitored phytochemcial study, BP.DR
06/60152-5 - Optimization and validation of method for the extraction and analysis of casearines of Casearia sylvestris, by CLAE, BP.IC
06/57101-0 - Phytochemical study of the antioxidant and cytotoxic activities of Myrciaria cauliflora Berg. (Myrtaceae), BP.IC
06/57114-4 - Implantation of trials for triage on a greater scale using a micro-circuit board multidetection reader for analysis of vegetal extracts and substances, BP.PD
06/57875-5 - Search for potential antitumoral, antioxidant, antiinflammatory, antifungal, antidiabetic, acetylcholinesterase and mieloperoxidase inhibitory natural compounds from Cerrado and Atlantic Forest, BP.TT
06/55162-1 - Chemical and antioxidant studies of two species of the Lippia genus native to the São Paulo cerrado: L. salviaefolia and L. velutina (Berbenaceae), BP.DR
05/60029-6 - Antiproliferative and cytoxic evaluation of potential inhibitors of hypusination of the factor of the 5th translation initiation (EIF5A), BP.IC
05/56867-6 - Search for potential antitumoral, antioxidant, antiinflammatory, antifungal, antidiabetic, acetylcholinesterase and mieloperoxidase mieloperoxidase inhibitory natural compounds from Cerrado and atla, BP.TT
05/52930-5 - Chemical study and study of the biological activities of Eugenia jambolana (Myrtaceae), BP.MS - associated scholarships
Associated research project(s): 07/90846-1
FAPESP publication about the research grant:http://media.fapesp.br/bv/uploads/publicacoes/pasta_biota_10.pdf
Abstract
The changing strategies for preservation and sustainable of diversity in Brazil in the past few years evidences the intrinsic value this enormous biological resource of potentially new bioactive compounds, and represents one of the greatest challenges nowadays facing the accelerated process of devastation of several Brazilian biomes. The systematic bioactivity evaluation of crude extracts and pure compounds from São Paulo state biota associated with additional information on chromatographic profile, spectrometric data and/or biological activity shall result in value-added material, which will be available for further studies. The might converge to hits or lead compounds to pharmaceutical, agroceutical, nutraceutical, cosmetics industry, which is expected to bring great contribution for conservation and sustainable economic development from the biodiversity of São Paulo state. (AU)

Scientific publications (11)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ORLANDI SARDI, JANAINA DE CASSIA; PITANGUI, NAYLA DE SOUZA; RODRIGUEZ-ARELLANES, GABRIELA; LUCIA TAYLOR, MARIA; FUSCO-ALMEIDA, ANA MARIA; SOARES MENDES-GIANNINI, MARIA JOSE. Highlights in pathogenic fungal biofilms. REVISTA IBEROAMERICANA DE MICOLOGIA, v. 31, n. 1, p. 22-29, JAN 31 2014. Web of Science Citations: 0.
PRIETO, ALINE M.; DOS SANTOS, ANDRE G.; OLIVEIRA, ANA PAULA S.; CAVALHEIRO, ALBERTO J.; SILVA, DULCE H. S.; BOLZANI, VANDERLAN S.; VARANDA, ELIANA AP.; SOARES, CHRISTIANE P. Assessment of the chemopreventive effect of casearin B, a clerodane diterpene extracted from Casearia sylvestris (Salicaceae). Food and Chemical Toxicology, v. 53, p. 153-159, MAR 2013. Web of Science Citations: 2.
PRIETO, A. M.; SANTOS, A. G.; CSIPAK, A. R.; CALIRI, C. M.; SILVA, I. C.; ARBEX, M. A.; SILVA, F. S.; MARCHI, M. R. R.; CAVALHEIRO, A. J.; SILVA, D. H. S.; BOLZANI, V. S.; SOARES, C. P. Chemopreventive activity of compounds extracted from Casearia sylvestris (Salicaceae) Sw against DNA damage induced by particulate matter emitted by sugarcane burning near Araraquara, Brazil. Toxicology and Applied Pharmacology, v. 265, n. 3, p. 368-372, DEC 15 2012. Web of Science Citations: 0.
FUNARI, CRISTIANO SOLEO; GULLO, FERNANDA PATRICIA; NAPOLITANO, ASSUNTA; CARNEIRO, RENATO LAJARIM; SOARES MENDES-GIANNINI, MARIA JOSE; FUSCO-ALMEIDA, ANA MARISA; PIACENTE, SONIA; PIZZA, COSIMO; SIQUEIRA SILVA, DULCE HELENA. Chemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazil. Food Chemistry, v. 135, n. 3, p. 2086-2094, DEC 1 2012. Web of Science Citations: 2.
FLAUSINO, JR., O. A.; DUFAU, L.; REGASINI, L. O.; PETRONIO, M. S.; SILVA, D. H. S.; ROSE, T.; BOLZANI, V. S.; REBOUD-RAVAUX, M. Alkyl Hydroxybenzoic Acid Derivatives that Inhibit HIV-1 Protease Dimerization. Current Medicinal Chemistry, v. 19, n. 26, p. 4534-4540, SEP 2012. Web of Science Citations: 2.
FUNARI, CRISTIANO SOLEO; PASSALACQUA, THAIS GABAN; RINALDO, DANIEL; NAPOLITANO, ASSUNTA; FESTA, MICHELA; CAPASSO, ANNA; PIACENTE, SONIA; PIZZA, COSIMO; MARX YOUNG, MARIA CLAUDIA; DURIGAN, GISELDA; SIQUEIRA SILVA, DULCE HELENA. Interconverting flavanone glucosides and other phenolic compounds in Lippia salviaefolia Cham. ethanol extracts. Phytochemistry, v. 72, n. 16, p. 2052-2061, NOV 2011. Web of Science Citations: 7.
REGASINI, LUIS OCTAVIO; PIVATTO, MARCOS; SCORZONI, LILIANA; BENADUCCI, TATIANE; FUSCO-ALMEIDA, ANA MARISA; SOARES MENDES GIANNINI, MARIA JOSE; BARREIRO, ELIEZER JESUS; SIQUEIRA SIVA, DULCE HELENA; BOLZANI, VANDERLAN DA SILVA. Antimicrobial activity of Pterogyne nitens Tul., Fabaceae, against opportunistic fungi. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 20, n. 5, p. 706-711, OCT-NOV 2010. Web of Science Citations: 5.
MORAIS, MAURO C. C.; LUQMAN, SUAIB; KONDRATYUK, TAMARA P.; PETRONIO, MAICON S.; REGASINI, LUIS O.; SILVA, DULCE H. S.; BOLZANI, VANDERLAN S.; SOARES, CHRISTIANE P.; PEZZUTO, JOHN M. Suppression of TNF- induced NFB activity by gallic acid and its semi-synthetic esters: possible role in cancer chemoprevention. NATURAL PRODUCT RESEARCH, v. 24, n. 18, p. 1758-1765, 2010. Web of Science Citations: 8.
DE OLIVEIRA, ALINE M.; DOS SANTOS, ANDRE G.; DOS SANTOS, RAQUEL A.; CSIPAK, ANGELICA R.; OLIVATO, CAMILA; DA SILVA, ISABEL C.; DE FREITAS, MAURA B.; BASSI, CARMEN L.; CAVALHEIRO, ALBERTO J.; BOLZANI, VANDERLAN S.; SILVA, DULCE H. S.; SAKAMOTO-HOJO, ELZA T.; TAKAHASHI, CATARINA S.; SOARES, CHRISTIANE P. Ethanolic extract of Casearia sylvestris and its clerodane diterpen (caseargrewiin F) protect against DNA damage at low concentrations and cause DNA damage at high concentrations in mice's blood cells. MUTAGENESIS, v. 24, n. 6, p. 501-506, NOV 2009. Web of Science Citations: 4.
LUIS OCTÁVIO REGASINI; GERARDO MAGELA VIEIRA-JÚNIOR; DANIARA CRISTINA FERNANDES; VANDERLAN DA SILVA BOLZANI; ALBERTO JOSÉ CAVALHEIRO; DULCE HELENA SIQUEIRA SILVA. IDENTIFICATION OF TRITERPENES AND STEROLS FROM PTEROGYNE NITENS (FABACEAE-CAESALPINIOIDEAE) USING HIGH-RESOLUTION GAS CHROMATOGRAPHY. Journal of the Chilean Chemical Society, v. 54, n. 3, p. 218-221, 2009. Web of Science Citations: 5.
SARA REGINA DE MARQUI; RENATA BRIONÍZIO LEMOS; LUCIANA ÁVILA SANTOS; IAN CASTRO-GAMBOA; ALBERTO JOSÉ CAVALHEIRO; VANDERLAN DA SILVA BOLZANI; DULCE HELENA SIQUEIRA SILVA; LILIANA SCORZONI; ANA MARIA FUSCO-ALMEIDA; MARIA JOSÉ SOARES MENDES-GIANNINI; MARIA CLAUDIA MARX YOUNG; LUCE MARIA BRANDÃO TORRES. Saponinas antifúngicas de Swartzia langsdorffii. Química Nova, v. 31, n. 4, p. 828-831, 2008.
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